Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging
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TLDR
This Viewpoint highlights how recent advances in transition-metal chemistry are leading the way for a new generation of MRI contrast agents.Abstract:
Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI contrast agents have emerged in recent years. For patients suffering from severe renal impairment, there is an important unmet medical need to perform contrast-enhanced MRI without gadolinium. There are also concerns over the long-term effects of retained gadolinium within the general patient population. Demand for gadolinium-free MRI contrast agents is driving a new wave of inorganic chemistry innovation as researchers explore paramagnetic transition-metal complexes as potential alternatives. Furthermore, advances in personalized care making use of molecular-level information have motivated inorganic chemists to develop MRI contrast agents that can detect pathologic changes at the molecular level. Recent studies have highlighted how reaction-based modulation of transition-metal paramagnetism offers a highly effective mechanism to achieve MRI contrast enhancement that is specific to biochemical processes. This Viewpoint highlights how recent advances in transition-metal chemistry are leading the way for a new generation of MRI contrast agents.read more
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Journal ArticleDOI
Complexation of Mn(II) by Rigid Pyclen Diacetates: Equilibrium, Kinetic, Relaxometric, Density Functional Theory, and Superoxide Dismutase Activity Studies.
Zoltán Garda,Enikő Molnár,Nadège Hamon,José L. Barriada,David Esteban-Gómez,Balázs Váradi,Viktória Nagy,Kristof Pota,Ferenc K. Kálmán,Imre Tóth,Norbert Lihi,Carlos Platas-Iglesias,Éva Tóth,Raphaël Tripier,Gyula Tircsó +14 more
TL;DR: The 3,6-9-15-tetraazabicyclo [9.3] was used to stabilize the macrocyclic fragment of pyclen as discussed by the authors.
Journal ArticleDOI
Positron Emission Tomography-Magnetic Resonance Imaging Pharmacokinetics, In Vivo Biodistribution, and Whole-Body Elimination of Mn-PyC3A.
Iris Y. Zhou,Ian Ramsay,Ilknur Ay,Pamela Pantazopoulos,Nicholas J. Rotile,Alison Wong,Peter Caravan,Eric M. Gale +7 more
TL;DR: Dynamic PET-MRI data demonstrate that both Mn-PyC3A and Mn-DPDP were eliminated by mixed renal and hepatobiliary elimination but that a greater fraction of [Mn]Mn- PyC3a was eliminated by renal filtration.
Journal ArticleDOI
Dinuclear Fe(III) Hydroxypropyl-Appended Macrocyclic Complexes as MRI Probes.
TL;DR: In this paper, four high-spin Fe(III) macrocyclic complexes, including three dinuclear and one mononuclear complex, were prepared toward the development of more effective iron-based magnetic resonance imaging (MRI) contrast agents.
Journal ArticleDOI
Exceptional Manganese(II) Stability and Manganese(II)/Zinc(II) Selectivity with Rigid Polydentate Ligands
Patrick Cieslik,Peter Comba,Benedikt Dittmar,Daouda Ndiaye,Éva Tóth,Gunasekaran Velmurugan,Hubert Wadepohl +6 more
TL;DR: Two new bispidine derivatives are reported, which provide rigid and large coordination cavities that perfectly match the size of Mn II, yielding eight-coordinate Mn II complexes with record stabilities and inertness.
Journal ArticleDOI
Distinct Coordination Chemistry of Fe(III)-Based MRI Probes.
TL;DR: In this paper , the authors describe different classes of Fe(III) MRI probes with a focus on macrocyclic complexes and multinuclear complexes such as self-assembled metal organic polyhedra (MOP).
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