Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
Gregory L. Lyford,Kanato Yamagata,Walter E. Kaufmann,Carol A. Barnes,Laura K. Sanders,Neal G. Copeland,Debra J. Gilbert,Nancy A. Jenkins,Anthony Lanahan,Paul F. Worley +9 more
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Analysis of the deduced amino acid sequence indicates a region of homology with alpha-spectrin, and observations suggest that Arc may play a role in activity-dependent plasticity of dendrites.About:
This article is published in Neuron.The article was published on 1995-02-01 and is currently open access. It has received 1197 citations till now. The article focuses on the topics: SRGAP2 & FGF10.read more
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Synaptic plasticity and memory: an evaluation of the hypothesis
TL;DR: It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.
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Long-Term Potentiation and Memory
TL;DR: Lynch et al. as mentioned in this paper identified the cellular and molecu... cellular and memory cells in neuroscience is one of the most significant challenges in neuroscience and identified the most important genes for long-term potentiation and memory.
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Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease
Jorge J. Palop,Jeannie Chin,Erik D. Roberson,Jun Wang,Myo T. Thwin,Nga Bien-Ly,Jong Yoo,Kaitlyn Ho,Gui-Qiu Yu,Anatol C. Kreitzer,Steven Finkbeiner,Jeffrey L. Noebels,Lennart Mucke +12 more
TL;DR: It is reported that hAPP mice have spontaneous nonconvulsive seizure activity in cortical and hippocampal networks, which is associated with GABAergic sprouting, enhanced synaptic inhibition, and synaptic plasticity deficits in the dentate gyrus.
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Neural plasticity in the ageing brain
Sara N. Burke,Carol A. Barnes +1 more
TL;DR: Major advances in understanding of age-related changes in the medial temporal lobe and prefrontal cortex are discussed and how these changes in functional plasticity contribute to behavioural impairments in the absence of significant pathology.
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Addiction and the brain: The neurobiology of compulsion and its persistence
TL;DR: Evidence is reviewed for the possibility that compulsion and its persistence are based on a pathological usurpation of molecular mechanisms that are normally involved in memory, which is often initiated by exposure to drug-related cues.
References
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A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
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Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
TL;DR: The studies indicate that COX-2 expression may be important in regulating prostaglandin signaling in brain, and the marked inducibility in neurons by synaptic stimuli suggests a role in activity-dependent plasticity.
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