Association between catechol-O-methyltransferase functional polymorphism and male suicide completers.
TLDR
The results suggest that the Val/Val genotype is a protective factor against suicide in males, and this was not the case in females.About:
This article is published in Neuropsychopharmacology.The article was published on 2004-07-01 and is currently open access. It has received 62 citations till now. The article focuses on the topics: Catechol-O-methyl transferase & Genotype.read more
Citations
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Journal ArticleDOI
Effect of Catechol-O-Methyltransferase val158met Genotype on Attentional Control
Giuseppe Blasi,Venkata S. Mattay,Alessandro Bertolino,Alessandro Bertolino,Alessandro Bertolino,Brita Elvevåg,Joseph H. Callicott,Saumitra Das,Bhaskar Kolachana,Michael F. Egan,Terry E. Goldberg,Daniel R. Weinberger +11 more
TL;DR: Results indicate that met allele load and presumably enhanced dopaminergic tone improve the “efficiency” of local circuit processing within the cingulate cortex and thereby its function during AC.
Journal ArticleDOI
Genetics of suicide
TL;DR: The data have shown that the MAOA gene, which is consistently associated with impulsive-aggressive personality traits, is not related to suicide but might induce violent methods in subjects with other suicide risk factors.
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Catechol-O-Methyltransferase (COMT): A Gene Contributing to Sex Differences in Brain Function, and to Sexual Dimorphism in the Predisposition to Psychiatric Disorders
TL;DR: There are accumulating and in places compelling data showing that COMT differentially impacts on brain function and dysfunction in men and women, and it is anticipated that additional evidence will emerge for sexual dimorphisms not only in COMT but also in many other autosomal genes.
Journal ArticleDOI
The importance of norepinephrine in depression.
Chantal Moret,Mike Briley +1 more
TL;DR: Preclinical and clinical evidence suggest disturbances in serotonin (5-HT), norepinephrine (NE), and dopamine (DA) neurotransmission in the central nervous system contribute to depression.
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Low plasma BDNF is associated with suicidal behavior in major depression.
Yong Ku Kim,Heung Pyo Lee,Sung Doo Won,Eun Young Park,Hwa Young Lee,Bun Hee Lee,Sung Woo Lee,Dokyung Yoon,Changsu Han,Dai Jin Kim,So Hyun Choi +10 more
TL;DR: It is suggested that reduction of plasma BDNF level is related to suicidal behavior in major depression and thatBDNF level may be a biological marker of suicidal depression.
References
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Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Herbert M. Lachman,Demitri F. Papolos,Takuya Saito,Yue Min Yu,Carol L. Szumlanski,Richard M. Weinshilboum +5 more
TL;DR: The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.
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5-HIAA in the Cerebrospinal Fluid: A Biochemical Suicide Predictor?
TL;DR: Patients in the low 5-HIAA mode (below 15 ng/ml) attempted suicide significantly more often than those in the high mode, and they used more violent means.
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A Highly Significant Association between a COMT Haplotype and Schizophrenia
Sagiv Shifman,Michal Bronstein,Meira Sternfeld,Anne Pisanté-Shalom,Efrat Lev-Lehman,Avraham Weizman,Ilya Reznik,Baruch Spivak,Nimrod Grisaru,Leon Karp,Richard Schiffer,Moshe Kotler,Rael D. Strous,Marnina Swartz-Vanetik,Haim Y. Knobler,Eilat Shinar,Jacques S. Beckmann,Benjamin Yakir,Neil Risch,Naomi B. Zak,Ariel Darvasi +20 more
TL;DR: An efficient approach to gene discovery is reported that found a highly significant association between schizophrenia and a COMT haplotype and can be widely implemented for the genetic dissection of other common diseases.
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Global Variation in the Frequencies of Functionally Different catechol-O-methyltransferase Alleles
TL;DR: This is the first global survey of the COMT*L andCOMT*H allele frequencies, confirming and extending earlier studies to show significant world-wide variation and establishing the COMt*L allele as the derived allele unique to humans.
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Human catechol-O-methyltransferase down-regulation by estradiol.
TL;DR: It is proposed that E2 decreased COMT activity through down-regulation of its gene and protein expression mediated via ER interaction with response elements in the promoter region of the gene, and may explain the lower ofCOMT activity in women compared to that in men, and the beneficial effects of E2 therapy in post-menopausal Parkinson's disease patients.