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David B. Ramsden

Researcher at University of Birmingham

Publications -  177
Citations -  6058

David B. Ramsden is an academic researcher from University of Birmingham. The author has contributed to research in topics: Euthyroid & Nicotinamide N-methyltransferase. The author has an hindex of 37, co-authored 168 publications receiving 4643 citations. Previous affiliations of David B. Ramsden include Queen Elizabeth Hospital Birmingham & University of Hong Kong.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription.

Tao Xie, +2 more
- 01 Jul 1999 - 
TL;DR: These findings provide the first evidence and molecular mechanism for estrogen to inhibit COMT gene transcription, which may shed new insight into the role of estrogen in the pathophysiology of different human disorders.
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Human catechol-O-methyltransferase down-regulation by estradiol.

H Jiang, +3 more
- 01 Dec 2003 - 
TL;DR: It is proposed that E2 decreased COMT activity through down-regulation of its gene and protein expression mediated via ER interaction with response elements in the promoter region of the gene, and may explain the lower ofCOMT activity in women compared to that in men, and the beneficial effects of E2 therapy in post-menopausal Parkinson's disease patients.
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The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease.

Shirley Yin-Yu Pang, +7 more
- 16 Aug 2019 - 
TL;DR: Understanding the mechanisms involved in the initiation and progression of PD may lead to potential therapeutic targets to prevent or modify its course, and has implications on the development of appropriate animal models of PD which take all these factors into account.
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A study of five candidate genes in Parkinson’s disease and related neurodegenerative disorders

David Nicholl, +14 more
- 22 Oct 1999 - 
TL;DR: This is one of the most extensive candidate gene studies performed in PD and the first time that some of these loci have been studied in multiple system atrophy and progressive supranuclear palsy and found no role for these polymorphisms in the etiology of PD, ALS, multipleSystem atrophy, progressive suPRan nuclear palsy, or AD.