Journal ArticleDOI
Aza-BODIPY-Based Nanomedicines in Cancer Phototheranostics.
TLDR
Zhang et al. as discussed by the authors highlighted the recent contributions in the development of aza-boron-dipyrromethene (aza-BODIPY) based nanomedicines.Abstract:
Cancer phototheranostics, composed of optical diagnosis and phototherapy (including photodynamic therapy and photothermal therapy), is a promising strategy for precise tumor treatment. Due to the unique properties of near-infrared absorption/emission, high reactive oxygen species generation, and photothermal conversion efficiency, aza-boron-dipyrromethene (aza-BODIPY), as an emerging organic photosensitizer, has shown great potential for tumor phototheranostics. By encapsulating aza-BODIPY photosensitizers within functional amphiphilic polymers, we can afford hydrophilic nanomedicines that selectively target tumor sites via an enhanced permeability and retention effect, thereby efficiently improving diagnosis and therapeutic efficacy. Herein, in this spotlight article, we attempt to highlight our recent contributions in the development of aza-BODIPY-based nanomedicines, which comprises three main sections: (1) to elucidate the design strategy of aza-BODIPY photosensitizers and corresponding nanomedicines; (2) to overview their photophysical properties and biomedical applications in phototheranostics, including fluorescence imaging, photoacoustic imaging, photodynamic therapy, photothermal therapy, and synergistic therapy; and (3) to depict the challenges and future perspectives of aza-BODIPY nanomedicines. It is believed that this Spotlight on Applications article would illuminate the way of developing new aza-BODIPY nanomedicines as well as other organic photosensitizer-based nanomedicines for future clinical translation.read more
Citations
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Journal ArticleDOI
Type I Photosensitizers Revitalizing Photodynamic Oncotherapy
TL;DR: A literature review of representative type I photosensitizers (including nanomaterials and small molecules) is presented with impetus to delineate their novel designs, action mechanisms, as well as anticancer PDT applications as discussed by the authors.
Journal ArticleDOI
Recent developments of BODIPY-based colorimetric and fluorescent probes for the detection of reactive oxygen/nitrogen species and cancer diagnosis
Van-Nghia Nguyen,Van-Nghia Nguyen,Jeongsun Ha,Moonyeon Cho,Haidong Li,K.M.K. Swamy,Juyoung Yoon +6 more
TL;DR: This review highlighted the design principle and applications of fluorescent probes on the basis of the BODIPY skeleton since 2015, ranging from B ODIPY/aza-BODIPy small molecules and macromolecules to delicate nanoparticles for tracking of ROS/RNS and cancer imaging.
Journal ArticleDOI
ROS-responsive cyclodextrin nanoplatform for combined photodynamic therapy and chemotherapy of cancer
TL;DR: This work designed a highly sensitive reactive oxygen species (ROS)-responsive polymer PCP which encapsulated doxorubicin (DOX) and purpurin 18 (P18) to achieve the synergy of photodynamic and chemotherapy to provide an effective strategy for the application of collaborative anti-tumor therapy.
Journal ArticleDOI
Small Molecular NIR-II Fluorophores for Cancer Phototheranostics.
TL;DR: This review summarizes the progress of small molecular NIR-II fluorophores with different central cores for cancer phototheranostics in the past few years, focusing on the molecular structures and Phototheranostic performances.
Journal ArticleDOI
Photodynamic therapy: photosensitizers and nanostructures
Alberto Escudero,Carolina Carrillo-Carrión,Mª Carmen Castillejos,Elena Romero-Ben,Christian Rosales-Barrios,Noureddine Khiar +5 more
TL;DR: This review will summarise the current state-of-the-art in PDT, with special focus on the different available photosensitizers, their chemistry, their incorporation into different nanostructures, and some of the current targeting strategies.
References
More filters
Journal ArticleDOI
Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs
Lihong V. Wang,Song Hu +1 more
TL;DR: A review of the state of the art of photoacoustic tomography for both biological and clinical studies can be found in this paper, where the authors discuss the current state-of-the-art and discuss future prospects.
Journal ArticleDOI
Nanoparticles in photodynamic therapy.
TL;DR: This paper presents a meta-modelling study of the response of the immune system to chemotherapy and its applications in the context of central nervous system disorders.
Journal ArticleDOI
Functional Nanomaterials for Phototherapies of Cancer
Journal ArticleDOI
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
Journal ArticleDOI
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Matthew M. Gubin,Xiuli Zhang,Heiko Schuster,Etienne Caron,Jeffrey P. Ward,Takuro Noguchi,Yulia Ivanova,Jasreet Hundal,Cora D. Arthur,Willem Jan Krebber,Gwenn E. Mulder,Mireille Toebes,Matthew D. Vesely,Samuel S. K. Lam,Alan J. Korman,James P. Allison,Gordon J. Freeman,Arlene H. Sharpe,Erika L. Pearce,Ton N. Schumacher,Ruedi Aebersold,Hans-Georg Rammensee,Cornelis J. M. Melief,Elaine R. Mardis,William E. Gillanders,Maxim N. Artyomov,Robert D. Schreiber +26 more
TL;DR: Tumour-specific mutant proteins are identified as a major class of T-cell rejection antigens following anti-PD-1 and/or anti-CTLA-4 therapy of mice bearing progressively growing sarcomas, and it is shown that therapeutic synthetic long-peptide vaccines incorporating these mutant epitopes induce tumour rejection comparably to checkpoint blockade immunotherapy.