Journal ArticleDOI
Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
TLDR
Berberine-induced AMPK activation inhibits the metastatic potential of tumor cells through a reduction in the activity of the ERK signaling pathway and COX-2 protein levels and a decrease in ERK activity and protein levels of cyclooxygenase-2 by a berberine -induced AM PK activation.About:
This article is published in Biochemical Pharmacology.The article was published on 2012-02-01. It has received 149 citations till now. The article focuses on the topics: AMPK & MEK inhibitor.read more
Citations
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Journal ArticleDOI
Berberine: new perspectives for old remedies.
TL;DR: A growing body of reports supports the evidence that berberine has anticancer effects, being able to block the proliferation of and to kill cancer cells.
Journal ArticleDOI
Targeting AMPK for cancer prevention and treatment
TL;DR: The role of AMPK in regulating inflammation, metabolism, and other regulatory processes with an emphasis on cancer is reviewed and the potential for targeting AMPK to treat various types of cancer is discussed.
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Overcoming cancer therapeutic bottleneck by drug repurposing
TL;DR: This review presents various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono- or drug combination therapy.
Journal ArticleDOI
Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis.
TL;DR: The exploration of synergistic mechanisms of herbal ingredients will not only help researchers to discover new phytomedicines or drug combinations but also help to avoid the possible negative synergy.
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Targeting arachidonic acid pathway by natural products for cancer prevention and therapy.
Nagendra Sastry Yarla,Anupam Bishayee,Gautam Sethi,Pallu Reddanna,Arunasree M. Kalle,Bhadrapura Lakkappa Dhananjaya,Kaladhar S. V. G. K. Dowluru,Ramakrishna Chintala,Govinda Rao Duddukuri +8 more
TL;DR: The possible utility of natural products as preventive and therapeutic agents against various oncologic diseases, including prostate, pancreatic, lung, skin, gastric, oral, blood, head and neck, colorectal, liver, cervical and breast cancers, is critically discussed.
References
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Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
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Cyclooxygenase in biology and disease
Raymond N. DuBois,Steven B. Abramson,Leslie J. Crofford,Rajnish A. Gupta,Lee S. Simon,Leo B A van de Putte,Peter E. Lipsky +6 more
TL;DR: The current understanding of the role of cyclooxygenase‐1 and ‐2 in different physiological situations and disease processes ranging from inflammation to cancer is summarized.
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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
TL;DR: A number of recent breakthroughs in the mechanistic understanding of AMPK function are reviewed, focusing on a number of newly identified downstream effectors of AM PK.
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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
TL;DR: AMP-activated protein kinase and SNF1-related protein kinases in higher plants are likely to be involved in the response of plant cells to environmental and/or nutritional stress.
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Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States
Yun Sok Lee,Woo S Kim,Kang H Kim,Myung J Yoon,Hye Jin Cho,Yun Shen,Ji-Ming Ye,Chul H Lee,Oh Won Keun,Chul Tae Kim,Cordula Hohnen-Behrens,Alison Gosby,Edward W. Kraegen,David E. James,JaeBum Kim +14 more
TL;DR: It is suggested that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity.