Bile acid nuclear receptor FXR and digestive system diseases
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TLDR
Current knowledge of the roles of FXR in physiology of the digestive system and the related diseases is discussed, with a focus on inflammatory bowel disease, colorectal cancer and type 2 diabetes.About:
This article is published in Acta Pharmaceutica Sinica B.The article was published on 2015-03-01 and is currently open access. It has received 259 citations till now. The article focuses on the topics: Farnesoid X receptor & FGF19.read more
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Mechanisms of Diabetes Improvement Following Bariatric/Metabolic Surgery
TL;DR: Embracing this approach through the application of detailed phenotyping, genomics, metabolomics, and gut microbiome studies will enhance the understanding of metabolic regulation and help identify novel therapeutic targets.
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Metabolite-Sensing G Protein-Coupled Receptors-Facilitators of Diet-Related Immune Regulation.
TL;DR: It is proposed that the host responds to deficiency (or sufficiency) of dietary and bacterial metabolites in a dynamic way, to optimize responses and survival and contribute to human diseases such as asthma, food allergies, type 1 and type 2 diabetes, hepatic steatosis, cardiovascular disease, and inflammatory bowel diseases.
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Emerging roles of bile acids in mucosal immunity and inflammation.
TL;DR: The three-dimensional interplay between bile acids, the microbiota, and the mucosal immune system is discussed, focusing on the mechanisms that regulate intestinal homeostasis and inflammation.
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Dysbiosis of gut microbiota in promoting the development of colorectal cancer
TL;DR: This review summarizes current studies regarding the association between gastrointestinal microbiota and the development of CRC, which provides insights into the therapeutic strategy of CRC.
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A selective gut bacterial bile salt hydrolase alters host metabolism
Lina Yao,Sarah Craven Seaton,Sula Ndousse-Fetter,Arijit A. Adhikari,Nicholas DiBenedetto,Amir I. Mina,Alexander S. Banks,Lynn Bry,A. Sloan Devlin +8 more
TL;DR: It is demonstrated that metabolites generated by a single microbial gene and enzymatic activity can profoundly alter host metabolism and gene expression at local and organism-level scales.
References
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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
TL;DR: The GLOBOCAN series of the International Agency for Research on Cancer (IARC) as mentioned in this paper provides estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012.
Journal ArticleDOI
Identification of a Nuclear Receptor for Bile Acids
Makoto Makishima,Arthur Y. Okamoto,Joyce J. Repa,Hua Tu,R. Marc Learned,Alvin Luk,Mitchell V. Hull,Kevin D. Lustig,David J. Mangelsdorf,Bei Shan +9 more
TL;DR: Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor, which demonstrates a mechanism by which bile acid transcriptionally regulate their biosynthesis and enterohepatic transport.
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Bile salt biotransformations by human intestinal bacteria.
TL;DR: The potential exists for altering the bile acid pool by targeting key enzymes in the 7α/β-dehydroxylation pathway through the development of pharmaceuticals or sequestering bile acids biologically in probiotic bacteria, which may result in their effective removal from the host after excretion.
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Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Derek J. Parks,Steven G. Blanchard,Randy K. Bledsoe,Gyan Chandra,Thomas G. Consler,Steven A. Kliewer,Julie B. Stimmel,Timothy M. Willson,Ann Marie Zavacki,David D. Moore,Jürgen M. Lehmann +10 more
TL;DR: Results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis and modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1.
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A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Bryan Goodwin,Stacey A. Jones,Roger R. Price,Michael A. Watson,D.D. McKee,Linda B. Moore,Cristin M. Galardi,Joan G. Wilson,Michael C. Lewis,Matthew E. Roth,Patrick R. Maloney,Timothy M. Willson,Steven A. Kliewer +12 more
TL;DR: A potent, nonsteroidal FXR ligand is used to show that FXR induces expression of small heterodimer partner 1 (SHP-1), an atypical member of the nuclear receptor family that lacks a DNA-binding domain that provides a molecular basis for the coordinate suppression of CYP7A1 and other genes involved in bile acid biosynthesis.