Binding mode of SARS-CoV-2 fusion peptide to human cellular membrane.
TLDR
In this article, the authors used an array of molecular dynamics simulations that take advantage of the highly mobile membrane mimetic model to investigate the interaction of the SARS-CoV2 FP with a lipid bilayer representing mammalian cellular membranes at an atomic level and to characterize the membrane-bound form of the peptide.About:
This article is published in Biophysical Journal.The article was published on 2021-03-04 and is currently open access. It has received 28 citations till now. The article focuses on the topics: Host cell membrane & Lipid bilayer fusion.read more
Citations
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Journal ArticleDOI
Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide.
TL;DR: In this article, the authors predicted the preferred positions of Ca2+ binding to the SARS-CoV-2-FP, the role of ca2+ ions in mediating peptide-membrane interactions, and the preferred mode of insertion of the Ca2-bound SARS CoV2-2FP, and consequent effects on the lipid bilayer from extensive atomistic molecular dynamics simulations and trajectory analyses.
Journal ArticleDOI
Could metabolomics drive the fate of COVID-19 pandemic? A narrative review on lights and shadows.
Michele Mussap,Vassilios Fanos +1 more
TL;DR: In this paper, a limited number of metabolomics-and lipidomics-based clinical studies in COVID-19 patients have been published and are discussed in this review, where remarkable alterations in the lipid and amino acid metabolism depict the molecular phenotype of subjects infected by SARS-CoV-2.
Journal ArticleDOI
Binding of SARS-CoV-2 Fusion Peptide to Host Endosome and Plasma Membrane.
TL;DR: In this paper, the SARS-CoV-2 virus fuses its viral envelope with cellular membranes of its human host and forms an anchor strong enough to withstand the mechanical force during membrane fusion.
Journal ArticleDOI
Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion.
TL;DR: In this paper, an all-atom model with simplified energetics was used to perform thousands of simulations in which the protein transitions between the prefusion and post-fusion conformations.
Journal ArticleDOI
COVID-19 and Neurodegenerative Diseases: Prion-Like Spread and Long-Term Consequences.
TL;DR: It is hypothesized that people with neurodegenerative diseases, Parkinson's disease, and aged people are at higher risk of getting the COVID-19 than normal adults and that the risk of having the infection increases with dementia and that infected people with severe symptoms could develop dementia as a long-term consequence.
References
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Journal ArticleDOI
Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin.
TL;DR: The N-terminal domain of the influenza hemagglutinin is deduced to be a kinked, predominantly helical amphipathic structure that could perturb lipid packing and facilitate lipid mixing between juxtaposed membranes.
Journal ArticleDOI
Composition of phospholipids and of phospholipid fatty acids and aldehydes in human red cells
TL;DR: Improved methods for lipid analysis that have been developed recently were employed to reevaluate the phospholipid composition, the fatty acid and fatty aldehyde composition of the total phospholIPid, and the fatty acids and fatty Aldehydes of the individualospholipids of normal human red cells.
Journal ArticleDOI
Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Robert N. Kirchdoerfer,Nianshuang Wang,Jesper Pallesen,Daniel Wrapp,Daniel Wrapp,Hannah L. Turner,Christopher A. Cottrell,Kizzmekia S. Corbett,Barney S. Graham,Jason S. McLellan,Jason S. McLellan,Andrew B. Ward +11 more
TL;DR: Cryo-EM analyses of a stabilized trimeric SARS-CoV S, as well as the trypsin-cleaved, stabilized S, and its interactions with ACE2 are presented, finding that neither binding to ACE2 nor cleavage bytrypsin at the S1/S2 cleavage site impart large conformational changes within stabilized SARV S.
Journal ArticleDOI
Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues.
TL;DR: The therapeutic potential of manipulating membrane lipid composition with approaches like membrane lipid therapy, aiming to normalize cell functions through the modification of membrane lipid bilayers is explored.
Book ChapterDOI
The many mechanisms of viral membrane fusion proteins.
TL;DR: Recent advances in the understanding of how fusion proteins are activated, how fusionprotein change conformation during fusion, and what is happening to the lipids during fusion are reviewed.