Biological activities of fibroblast growth factor-2 in the adult myocardium.
TLDR
An overview of current insights into the multiple roles of FGF-2 in the myocardium, as they pertain to two basic phenomena: ischemia-reperfusion injury and cardiac hypertrophy, is given.Abstract:
Fibroblast growth factor-2 (FGF-2) is a potent regulator of many cellular functions and phenomena, including cell proliferation, differentiation, survival, adhesion, migration, motility and apoptosis, and processes such as limb formation, wound healing, tumorigenesis, angiogenesis, vasculogenesis and blood vessel remodeling. In the adult myocardium, FGF-2 is expressed by various cell types, including cardiomyocytes, fibroblasts and smooth muscle cells. The biological effects of FGF-2 in the myocardium are mediated by the high-affinity tyrosine kinase receptor FGFR-1, the major FGF receptor in the heart. Here, we give an overview of current insights into the multiple roles of FGF-2 in the myocardium, as they pertain to two basic phenomena: ischemia-reperfusion injury and cardiac hypertrophy. The first category includes roles for FGF-2 in cardioprotection, the inflammatory response, angiogenesis and vascular remodeling, while the second includes myocyte hypertrophy, fibrosis, and gap junction functioning (conduction). Given the strong evidence for FGF-2 as both a cardioprotective and angiogenic agent, the therapeutic potential of FGF-2 in the ischemic myocardium is discussed.read more
Citations
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Journal ArticleDOI
FGF23 induces left ventricular hypertrophy
Christian Faul,Ansel P. Amaral,Behzad N. Oskouei,Ming Chang Hu,Alexis Sloan,Tamara Isakova,Orlando M. Gutiérrez,Robier Aguillon-Prada,Joy Lincoln,Joshua M. Hare,Peter Mundel,Azorides R. Morales,Julia J. Scialla,Michael J. Fischer,Michael J. Fischer,Elsayed Z. Soliman,Jing Chen,Alan S. Go,Sylvia E. Rosas,Lisa Nessel,Raymond R. Townsend,Harold I. Feldman,Martin St. John Sutton,Akinlolu O. Ojo,Crystal A. Gadegbeku,Giovana Seno Di Marco,Stefan Reuter,Dominik Kentrup,Klaus Tiemann,Marcus Brand,Joseph A. Hill,Orson W. Moe,Makoto Kuro-o,John W. Kusek,Martin G. Keane,Myles Wolf +35 more
TL;DR: It is reported that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort and suggested that chronically elevated F GF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD.
Journal ArticleDOI
The immune system and cardiac repair
TL;DR: Targeting inflammatory pathways following infarction may reduce cardiomyocyte injury and attenuate adverse remodeling, and understanding the role of the immune system in cardiac repair is necessary in order to design optimal strategies for cardiac regeneration.
Journal ArticleDOI
The Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein With Mortality in Coronary Artery Disease: The Heart and Soul Study
Benjamin D. Parker,Leon J. Schurgers,Vincent Brandenburg,Robert H. Christenson,Cees Vermeer,Markus Ketteler,Michael G. Shlipak,Mary A. Whooley,Joachim H. Ix +8 more
TL;DR: In outpatients with stable CAD, higher FGF23 and lower ucMGP levels are independently associated with mortality and CVD events.
OtherDOI
Pathophysiology of Myocardial Infarction.
TL;DR: The molecular signals and cellular effectors implicated in injury, repair, and remodeling of the infarcted heart, the mechanistic basis of the most common complications associated with myocardial infarction, and the pathophysiologic effects of established treatment strategies are described.
Journal ArticleDOI
Fibroblasts in myocardial infarction: a role in inflammation and repair
TL;DR: Considering their abundance, their crucial role in cardiac inflammation and repair, and their involvement in myocardial dysfunction and arrhythmogenesis, cardiac fibroblasts may be key therapeutic targets in cardiac remodeling.
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