Biological response on a titanium implant-grade surface functionalized with modular peptides.
Hilal Yazici,Hanson Fong,Brandon Ruf Wilson,Ersin Emre Oren,F.A. Amos,Hangyu Zhang,John Spencer Evans,Malcolm L. Snead,Mehmet Sarikaya,Candan Tamerler,Candan Tamerler +10 more
TLDR
The functionalization of the Ti surface by the selected peptides significantly enhanced the bioactivity of osteoblast and fibroblast cells on implant-grade materials.About:
This article is published in Acta Biomaterialia.The article was published on 2013-02-01 and is currently open access. It has received 77 citations till now. The article focuses on the topics: Surface modification.read more
Citations
More filters
Journal ArticleDOI
Biointerface Structural Effects on the Properties and Applications of Bioinspired Peptide-Based Nanomaterials
Tiffany R. Walsh,Marc R. Knecht +1 more
TL;DR: How the versatility of this peptide-mediated approach for the growth, organization, and activation of nanomaterials could be more widely expanded via the elucidation of biointerfacial structure/property relationships is illustrated.
Journal ArticleDOI
Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells
Daniel Carson,Marketa Hnilova,Xiulan Yang,Cameron L. Nemeth,Jonathan H. Tsui,Alec S.T. Smith,Alex Jiao,Michael Regnier,Charles E. Murry,Candan Tamerler,Deok Ho Kim +10 more
TL;DR: A nanogrid culture array comprised of nanogrooved topographies, with groove widths ranging from 350 to 2000 nm, is presented to study the effect of different nanoscale structures on the structural development of hiPSC-CMs in vitro.
Journal ArticleDOI
Engineered Chimeric Peptides as Antimicrobial Surface Coating Agents toward Infection-Free Implants
Hilal Yazici,Mary B. O’Neill,Turgay Kacar,Turgay Kacar,Brandon Ruf Wilson,Ersin Emre Oren,Ersin Emre Oren,Mehmet Sarikaya,Candan Tamerler,Candan Tamerler +9 more
TL;DR: A chimeric peptide with bifunctionality that both forms a robust solid-surface coating while presenting antimicrobial property and demonstrates significant improvement in reducing bacterial colonization onto titanium surfaces below the detectable limit.
Journal ArticleDOI
The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
Nicolau B. da Cunha,Nicole Berwanger Cobacho,Juliane F.C. Viana,Loiane Alves de Lima,Kamila Botelho Sampaio,Stephan M. Dohms,Arthur C.R. Ferreira,Cesar de la Fuente-Nunez,Fabrício F. Costa,Octavio L. Franco,Octavio L. Franco,Simoni Campos Dias +11 more
TL;DR: Recent advances in the development of novel AMPs with improved antimicrobial activities that were achieved through characteristic structural design are outlined and progress made to overcome some of the major limitations that have hindered peptide biosynthesis are described.
Journal ArticleDOI
Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application
Lin Mao,Li Shen,Jiahui Chen,Yu Wu,Yu Wu,Minsuk Kwak,Yao Lu,Qiong Xue,Jia Pei,Lei Zhang,Guangyin Yuan,Rong Fan,Junbo Ge,Wenjiang Ding +13 more
TL;DR: The animal experiment via implantation of MgF2-coated JDBM stent to rabbit abdominal aorta confirms excellent tissue compatibility of the well re-endothelialized stent with no sign of thrombogenesis and restenosis in the stented vessel.
References
More filters
Journal ArticleDOI
VMD: Visual molecular dynamics
TL;DR: VMD is a molecular graphics program designed for the display and analysis of molecular assemblies, in particular biopolymers such as proteins and nucleic acids, which can simultaneously display any number of structures using a wide variety of rendering styles and coloring methods.
Journal ArticleDOI
All-atom empirical potential for molecular modeling and dynamics studies of proteins.
Alexander D. MacKerell,D. Bashford,M. Bellott,Roland L. Dunbrack,Jeffrey D. Evanseck,Martin J. Field,Stefan Fischer,Jiali Gao,H. Guo,S. Ha,Diane Joseph-McCarthy,L. Kuchnir,K. Kuczera,F. T. K. Lau,C. Mattos,Stephen W. Michnick,Thien H. Ngo,D. T. Nguyen,B. Prodhom,W. E. Reiher,Benoît Roux,M. Schlenkrich,Jeremy C. Smith,Roland H. Stote,John E. Straub,Masakatsu Watanabe,J. Wiórkiewicz-Kuczera,D. Yin,Martin Karplus +28 more
TL;DR: The results demonstrate that use of ab initio structural and energetic data by themselves are not sufficient to obtain an adequate backbone representation for peptides and proteins in solution and in crystals.
Journal ArticleDOI
Self-assembled monolayers of thiolates on metals as a form of nanotechnology.
Journal ArticleDOI
RGD and other recognition sequences for integrins.
TL;DR: As the integrin-mediated cell attachment influences and regulates cell migration, growth, differentiation, and apoptosis, the RGD peptides and mimics can be used to probe integrin functions in various biological systems.
Journal ArticleDOI
Titanium alloys in total joint replacement—a materials science perspective
Marc Long,H.J Rack +1 more
TL;DR: This review examines current information on the physical and mechanical characteristics of titanium alloys used in artifical joint replacement prostheses, with a special focus on those issues associated with the long-term prosthetic requirements, e.g., fatigue and wear.
Related Papers (5)
A hexapeptide motif that electrostatically binds to the surface of titanium.
Ken-Ichi Sano,Kiyotaka Shiba +1 more
Molecular biomimetics: utilizing nature's molecular ways in practical engineering
Candan Tamerler,Mehmet Sarikaya +1 more