Journal ArticleDOI
Bioprinting Toward Organ Fabrication: Challenges and Future Trends
Ibrahim T. Ozbolat,Yin Yu +1 more
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TLDR
RP-based bioprinting approaches are overviewed and the current challenges and trends toward fabricating living organs for transplant in the near future are discussed.Abstract:
Tissue engineering has been a promising field of research, offering hope for bridging the gap between organ shortage and transplantation needs. However, building three-dimensional (3-D) vascularized organs remains the main technological barrier to be overcome. Organ printing, which is defined as computer-aided additive biofabrication of 3-D cellular tissue constructs, has shed light on advancing this field into a new era. Organ printing takes advantage of rapid prototyping (RP) technology to print cells, biomaterials, and cell-laden biomaterials individually or in tandem, layer by layer, directly creating 3-D tissue-like structures. Here, we overview RP-based bioprinting approaches and discuss the current challenges and trends toward fabricating living organs for transplant in the near future.read more
Citations
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Journal ArticleDOI
Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels.
Thomas J. Hinton,Quentin Jallerat,Rachelle N. Palchesko,Joon Hyung Park,Martin S. Grodzicki,Hao Jan Shue,Mohamed H. Ramadan,Andrew Hudson,Adam W. Feinberg +8 more
TL;DR: Three-dimensional structures based on femurs, branched coronary arteries, trabeculated embryonic hearts, and human brains were mechanically robust and recreated complex 3D internal and external anatomical architectures.
Journal ArticleDOI
3D bioprinting for engineering complex tissues.
TL;DR: Combined with recent advances in human pluripotent stem cell technologies, 3D-bioprinted tissue models could serve as an enabling platform for high-throughput predictive drug screening and more effective regenerative therapies.
Journal ArticleDOI
Current advances and future perspectives in extrusion-based bioprinting.
TL;DR: This paper, presenting a first-time comprehensive review of EBB, discusses the current advancements in EBB technology and highlights future directions to transform the technology to generate viable end products for tissue engineering and regenerative medicine.
Organ Printing: Tissue Spheroids as Building Blocks
Vladimir Mironov,Jing Zhang,Carmine Gentile,K Brakke,Thomas C. Trusk,Karoly Jakab,Gabor Forgacs,Vladimirs Kasjanovs,Richard P. Visconti,Roger R. Markwald +9 more
TL;DR: Organ printing can be defined as layer-by-layer additive robotic biofabrication of three-dimensional functional living macrotissues and organ constructs using tissue spheroids as building blocks.
Journal ArticleDOI
Scaffolds for Bone Tissue Engineering: State of the art and new perspectives.
Livia Roseti,V. Parisi,Mauro Petretta,Carola Cavallo,Giovanna Desando,Isabella Bartolotti,Brunella Grigolo +6 more
TL;DR: It is highlighted that, despite its encouraging results, the clinical approach of Bone Tissue Engineering has not taken place on a large scale yet, due to the need of more in depth studies, its high manufacturing costs and the difficulty to obtain regulatory approval.
References
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Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
Journal ArticleDOI
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L. Drury,David J. Mooney +1 more
TL;DR: Hydrogels are an appealing scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner.
Journal ArticleDOI
Scaffold-free vascular tissue engineering using bioprinting.
TL;DR: A fully biological self-assembly approach, which is implemented through a rapid prototyping bioprinting method for scaffold-free small diameter vascular reconstruction and has the ability to engineer vessels of distinct shapes and hierarchical trees that combine tubes of distinct diameters.
Journal ArticleDOI
A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering
TL;DR: An overview on the different rapid prototyping techniques suitable for the processing of hydrogel materials, and a primary distinction will be made between (i) laser-based, (ii) nozzle- based, and (iii) printer-based systems.
Journal ArticleDOI
Organ printing: Tissue spheroids as building blocks☆
Vladimir Mironov,Richard P. Visconti,Vladimir Kasyanov,Gabor Forgacs,Christopher J. Drake,Roger R. Markwald +5 more
TL;DR: Organ printing is a new emerging enabling technology paradigm which represents a developmental biology-inspired alternative to classic biodegradable solid scaffold-based approaches in tissue engineering.