Journal ArticleDOI
Blockade of A2a Adenosine Receptors Positively Modulates Turning Behaviour and c-Fos Expression Induced by D1 Agonists in Dopamine-denervated Rats
TLDR
The results suggest that endogenous adenosine acting on A2a receptors can exert an inhibitory influence on the functional expression of D1‐mediated responses in dopamine‐denervated rats, and propose new possible therapeutic approaches in the treatment of Parkinson's disease.Abstract:
In rats with unilateral 6-hydroxydopamine lesions of the dopaminergic nigrostriatal pathway, administration of the A2a adenosine antagonist SCH 58261 alone did not induce any motor asymmetry but strongly potentiated the contralateral turning behaviour induced by the dopamine D1 agonist SKF 38393. SCH 58261 also increased the number of Fos-like positive nuclei induced by SKF 38393 in the 6-hydroxydopamine-lesioned striatum. Intense potentiation of D1-dependent turning behaviour and c-Fos expression was also observed after administration of the A2a/A1 antagonist CGS 15943. Administration of the A1 adenosine receptor antagonist DPCPX induced a small potentiation of D1-mediated contralateral turning while c-Fos expression induced by SKF 38393 was not modified. The results suggest that endogenous adenosine acting on A2a receptors can exert an inhibitory influence on the functional expression of D1-mediated responses in dopamine-denervated rats, and propose new possible therapeutic approaches in the treatment of Parkinson's disease.read more
Citations
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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
TL;DR: Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).
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Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia
Book ChapterDOI
Adenosine and Brain Function
TL;DR: Much additional work is needed to pinpoint the sites and mechanisms of action, as well as the roles in chronic pain states of adenosine A 2A receptors in neurodegenerative disorders and ARs in psychiatric disorders.
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Distribution, biochemistry and function of striatal adenosine A2A receptors
TL;DR: Current knowledge on the distribution, biochemistry and function of striatal A2A receptors is summarized and new selective antibodies, antagonist radioligands and optimized in situ hybridization protocols are provided.
Journal ArticleDOI
Targeting adenosine A2A receptors in Parkinson's disease.
TL;DR: A prime example of translational neuroscience is reviewed, through which antagonism of A2A receptors has now entered the arena of clinical trials with realistic prospects for advancing PD therapeutics.
References
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D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
Charles R. Gerfen,Thomas M. Engber,Lawrence C. Mahan,Zvi Susel,Thomas N. Chase,Frederick J. Monsma,David R. Sibley +6 more
TL;DR: The differential effects of dopamine on striatonigral and striatopallidal neurons are mediated by their specific expression of D1 and D2 dopamine receptor subtypes, respectively.
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Expression of c-fos protein in brain: metabolic mapping at the cellular level
TL;DR: Fos immunohistochemistry provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways in response to polysynaptic activation.
Journal ArticleDOI
The use of c-fos as a metabolic marker in neuronal pathway tracing.
Mike Dragunow,Richard L.M. Faull +1 more
TL;DR: The use of c-fos protein (Fos) immunocytochemistry as a metabolic marker for tracing neuroanatomical connections, seizure pathways and sites of action of neuroactive drugs is discussed in this report.
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James I. Morgan,Tom Curran +1 more
TL;DR: A stimulus-transcription coupling cascade, involving the products of the proto-oncogenes, c-fos and c-jun, that operates in many cell types including neurons is detailed, which is linked to long-term phenotypic changes that require alterations in gene expression.
Journal ArticleDOI
Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum
J. Stephen Fink,David R. Weaver,Scott A. Rivkees,Robert A. Peterfreund,Alexia E. Pollack,Elizabeth M. Adler,Steven M. Reppert +6 more
TL;DR: The co-expression of D2 dopamine and A2 adenosine receptors in a subset of striatal cells provides an anatomical basis for dopaminergic-adenosinergic interactions on motor behavior.