Journal ArticleDOI
Bone remodeling during fracture repair : The cellular picture
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TLDR
This review has attempted to examine catabolism/remodeling in fractures in a systematic fashion by examining the cellular participants in soft callus remodeling and in particular the role of the osteoclast in endochondral ossification.About:
This article is published in Seminars in Cell & Developmental Biology.The article was published on 2008-10-01. It has received 780 citations till now. The article focuses on the topics: Callus formation & Bone remodeling period.read more
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Inflammation, fracture and bone repair
Florence Loi,Luis A. Córdova,Luis A. Córdova,Jukka Pajarinen,Tzuhua Lin,Zhenyu Yao,Stuart B. Goodman +6 more
TL;DR: In this review, a comprehensive summary of the literature related to inflammation and bone repair is provided, placing special emphasis on the underlying cellular and molecular mechanisms, and potential interventions that can favorably modulate the outcome of clinical conditions that involve bone repair.
Journal ArticleDOI
Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration
Dongsu Park,Joel A. Spencer,Bong Ihn Koh,Tatsuya Kobayashi,Joji Fujisaki,Thomas L. Clemens,Charles P. Lin,Henry M. Kronenberg,David T. Scadden +8 more
TL;DR: Osteoblastic cells are defined as short-lived and nonreplicative, requiring replenishment from bone-marrow-derived, Mx1(+) stromal cells with "MSC" features, representing a highly dynamic and stress responsive stem/progenitor cell population of fate-restricted potential that feeds the high cell replacement demands of the adult skeleton.
Journal ArticleDOI
Strategies for Controlled Delivery of Growth Factors and Cells for Bone Regeneration
TL;DR: The role of various regenerative factors involved in bone healing and their appropriate combinations with different delivery systems for augmenting bone regeneration are discussed.
Journal ArticleDOI
Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives.
Antalya Ho-Shui-Ling,Johanna Bolander,Laurence E. Rustom,Amy J. Wagoner Johnson,Frank P. Luyten,Catherine Picart,Catherine Picart +6 more
TL;DR: This article reviews the different strategies to heal bone defects using synthetic bone graft substitutes, biologically active substances and stem cells, and discusses the remaining challenges that need to be addressed to significantly improve the healing of bone defects.
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Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice.
Xin Zhou,Klaus von der Mark,Stephen P. Henry,William Norton,Henry P. Adams,Benoit de Crombrugghe +5 more
TL;DR: Results show that both chondrocytes prior to initial ossification and growth plate chondROcytes before or after birth have the capacity to undergo transdifferentiation to become osteoblasts.
References
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Bone Resorption by Osteoclasts
TL;DR: Osteopetrotic mutants have provided a wealth of information about the genes that regulate the differentiation of osteoclasts and their capacity to resorb bone.
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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Young-Yun Kong,Hiroki Yoshida,Ildiko Sarosi,Hong-Lin Tan,Emma Timms,Casey Capparelli,Sean Morony,Antonio J. Oliveira-dos-Santos,Gwyneth Van,Annick Itie,Wilson Khoo,Andrew Wakeham,Colin R. Dunstan,David L. Lacey,Tak W. Mak,William J. Boyle,Josef M. Penninger +16 more
TL;DR: OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
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MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes
Thiennu H. Vu,J. Michael Shipley,Gabriele Bergers,Joel E. Berger,Jill A. Helms,Douglas Hanahan,Steven D. Shapiro,Robert M. Senior,Zena Werb +8 more
TL;DR: Transplantation of wild-type bone marrow cells rescues vascularization and ossification in gelatinase B-null growth plates, indicating that these processes are mediated by gelatinaseB-expressing cells of bone marrow origin, designated chondroclasts.
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Severely Suppressed Bone Turnover: A Potential Complication of Alendronate Therapy
Clarita V. Odvina,Joseph E. Zerwekh,D. Sudhaker Rao,Naim M. Maalouf,Frank A Gottschalk,Charles Y.C. Pak +5 more
TL;DR: The findings raise the possibility that severe suppression of bone turnover may develop during long-term alendronate therapy, resulting in increased susceptibility to, and delayed healing of, nonspinal fractures, and the need for increased awareness and monitoring.
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Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover
John Street,Min Bao,Leo Deguzman,Stuart Bunting,Franklin Peale,Napoleone Ferrara,Hope Steinmetz,John Hoeffel,Jeffrey L. Cleland,Ann L. Daugherty,Nicholas van Bruggen,H. Paul Redmond,Richard A.D. Carano,Ellen Filvaroff +13 more
TL;DR: The responses to exogenous VEGF observed in two distinct model systems and species indicate that a slow-release formulation of V EGF, applied locally at the site of bone damage, may prove to be an effective therapy to promote human bone repair.