Journal ArticleDOI
Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer
Eugenia E. Calle,Clark W. Heath,R. J. Coates,Jonathan M. Liff,Silvia Franceschi,R. Talamini,N. Chantarakul,Suporn Koetsawang,D. Rachawat,A. Morabia,L. Schuman,Walter F. Stewart,Moyses Szklo,Chris Bain,F. Schofield,Victor Siskind,Philip A. Band,Andrew J. Coldman,Richard P. Gallagher,T. G. Hislop,P. Yang,Stephen W. Duffy,L. M. Kolonel,A. M.Y. Nomura,Mark W. Oberle,Howard W. Ory,Herbert B. Peterson,Hoyt G. Wilson,Phyllis A. Wingo,K. Ebeling,D. Kunde,P. Nishan,Graham A. Colditz,Nicholas G. Martin,Tieng Pardthaisong,S. Silpisornkosol,C. Theetranont,B. Boosiri,S. Chutivongse,P. Jimakorn,Pramuan Virutamasen,C. Wongsrichanalai,Anthony J. McMichael,T. Rohan,Marianne Ewertz,Carle Paul,David C. G. Skegg,G. F. S. Spears,P. Boyle,M. Evstifeeva,J. R. Daling,W. B. Hutchinson,Kathi Malone,E. A. Noonan,Janet L. Stanford,David B. Thomas,N. S. Weiss,Emily White,N. Andrieu,A. Bràmond,F Clavel,B. Gairard,J. Lansac,L. Piana,R. Renaud,S. R.P. Fine,H. R. Cuevas,P. Ontiveros,A. Palet,S. B. Salazar,N. Aristizabel,A. Cuadros,A. Bachelot,M. G. Lê,J. Deacon,Julian Peto,C. N. Taylor,E. Alfandary,Baruch Modan,Elaine Ron,Gary D. Friedman,Robert A. Hiatt,T. Bishop,J. Kosmelj,M. Primic-Zakelj,B. Ravnihar,J. Stare,W. L. Beeson,Graeme Fraser,R. D. Bulbrook,Jack Cuzick,I. S. Fentiman,J. L. Hayward,De Yun Wang,R. L. Hanson,M. C. Leske,Martin C. Mahoney,P. C. Nasca,A. O. Varma,A. L. Weinstein,Torgil Möller,Håkan Olsson,Jonas Ranstam,R.A. Goldbohm,P.A. van den Brandt,R. A. Apelo,J. Baens,J. R. de la Cruz,B. Javier,L. B. Lacaya,Corazon A. Ngelangel,C. La Vecchia,E. Negri,Ettore Marubini,Monica Ferraroni,Mariette Gerber,Sylvia Richardson,C. Segala,D. Gatei,P. Kenya,A. Kungu,J. G. Mati,L A Brinton,Robert N. Hoover,Catherine Schairer,Robert Spirtas,H. P. Lee,Matti A. Rookus,F.E. van Leeuwen,J. A. Schoenberg,Marilie D. Gammon,E. A. Clarke,Lee W. Jones,Klim McPherson,A. Neil,M. Vessey,D. Yeates,Valerie Beral,Diana Bull,B. Crossley,C Hermon,Simon Jones,Timothy J. Key,Claire E. Lewis,Gillian K Reeves,Rory Collins,Richard Doll,Richard Peto,P. Hannaford,Kay Cr,Luis Rosero-Bixby,Jian-Min Yuan,H. Y. Wei,T. Yun,C. Zhiheng,G. Berry,J Cooper Booth,T. Jelihovsky,Robert MacLennan,R. Shearman,Q. S. Wang,C. J. Baines,Anthony B. Miller,C. Wall,Eiliv Lund,H. Stalsberg,A. Dabancens,L. Martinez,R. Molina,O. Salas,Freda E. Alexander,B. S. Hulka,C. E. D. Chilvers,Leslie Bernstein,Robert W. Haile,Annlia Paganini-Hill,M. C. Pike,R. K. Ross,Giske Ursin,Mimi C. Yu,M. P. Longnecker,Polly A. Newcomb,T. M.N. Farley,S. Holck,O. Meirik,Hans-Olov Adami,R. Bergkvist,Ingemar Persson,Fabio Levi,Kiyohiko Mabuchi,Dale L. Preston,Klea Katsouyanni,Antonia Trichopoulou,D. Trichopoulos,Leif Bergkvist +194 more
TLDR
Of the many factors examined that might affect the relation between breast cancer risk and use of HRT, only a woman's weight and body-mass index had a material effect: the increase in the relative risk of breast cancer diagnosed in women using HRT and associated with long durations of use in current and recent users was greater for women of lower than of higher weight or body- mass index.About:
This article is published in The Lancet.The article was published on 1997-10-11. It has received 2343 citations till now. The article focuses on the topics: Breast cancer & Million Women Study.read more
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Journal ArticleDOI
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
Journal ArticleDOI
Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Stephen B. Hulley,Deborah Grady,Trudy L. Bush,Curt D Furberg,David M. Herrington,Betty Riggs,Eric Vittinghoff +6 more
TL;DR: Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease and the treatment did increase the rate of thromboembolic events and gallbladder disease.
Journal ArticleDOI
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
Garnet L. Anderson,Marian C. Limacher,Annlouise R. Assaf,Tamsen Bassford,Shirley A.A. Beresford,Henry R. Black,Denise E. Bonds,Robert L. Brunner,Robert G. Brzyski,Bette J. Caan,Rowan T. Chlebowski,J. David Curb,Margery Gass,Jennifer Hays,Gerardo Heiss,Susan L. Hendrix,Barbara V. Howard,Judith Hsia,F. Allan Hubbell,Rebecca D. Jackson,Karen C. Johnson,Howard L. Judd,Jane Morley Kotchen,Lewis H. Kuller,Andrea Z. LaCroix,Dorothy S. Lane,Robert Langer,Norman L. Lasser,Cora E. Lewis,JoAnn E. Manson,Karen L. Margolis,Judith K. Ockene,Mary Jo O'Sullivan,Lawrence S. Phillips,Ross L. Prentice,Cheryl Ritenbaugh,John A Robbins,Jacques E. Rossouw,Gloria E. Sarto,Marcia L. Stefanick,Linda Van Horn,Jean Wactawski-Wende,Robert B. Wallace,Sylvia Wassertheil-Smoller +43 more
TL;DR: The use of conjugated equine estrogen (CEE) increases the risk of stroke, decreases therisk of hip fracture, and does not affect CHD incidence in postmenopausal women with prior hysterectomy over an average of 6.8 years, indicating no overall benefit.
Journal ArticleDOI
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle,Rudolf Kaaks +1 more
TL;DR: Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.
Journal ArticleDOI
Breast cancer and hormone-replacement therapy in the Million Women Study.
TL;DR: Current use of HRT is associated with an increased risk of incident and fatal breast cancer; the effect is substantially greater for oestrogen-progestagen combinations than for other types of H RT.
References
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Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: This report is the first simple account yet published for non-statistical physicians of how to analyse efficiently data from clinical trials of survival duration, and it may be preferable to use these statistical methods to study time to local recurrence of tumour, or toStudy time to detectable metastatic spread, in addition to studying total survival.
Journal ArticleDOI
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women.
Graham A. Colditz,Susan E. Hankinson,David J. Hunter,Walter C. Willett,JoAnn E. Manson,Meir J. Stampfer,Charles H. Hennekens,Bernard Rosner,Frank E. Speizer +8 more
TL;DR: In this paper, the effect of adding progestins to estrogen therapy on the risk of breast cancer in postmenopausal women is investigated. But, the effect on the number of newly diagnosed invasive breast cancer cases was not quantified.
Journal ArticleDOI
Breast cancer and hormonal contraceptives : collaborative reanalysis of individual data on 53.297 women with breast cancer and 100.239 women without breast cancer from 54 epidemiological studies
Eugenia E. Calle,Clark W. Heath,H. L. Miracle-McMahill,R. J. Coates,Jonathan M. Liff,Silvia Franceschi,R. Talamini,N. Chantarakul,Suporn Koetsawang,D. RachawatRachawat,A. Morabia,L. Schuman,Walter F. Stewart,Moyses Szklo,Chris Bain,F. Schofield,Victor Siskind,Philip A. Band,Andrew J. Coldman,Richard P. Gallagher,T. G. Hislop,P. Yang,Stephen W. Duffy,L. M. Kolonel,A. M.Y. Nomura,Mark W. Oberle,Howard W. Ory,Herbert B. Peterson,Hoyt G. Wilson,Phyllis A. Wingo,K. Ebeling,D. Kunde,P. Nishan,Graham A. Colditz,Nicholas G. Martin,Tieng Pardthaisong,S. Silpisornkosol,C. Theetranont,B. Boosiri,S. Chutivongse,P. Jimakorn,Pramuan Virutamasen,C. Wongsrichanalai,Anthony J. McMichael,T. Rohan,Marianne Ewertz,Carle Paul,David C. G. Skegg,Peter Boyle,M. Evstifeeva,J. R. Daling,Kathi Malone,E. A. Noonan,Janet L. Stanford,David B. Thomas,N. S. Weiss,Emily White,N. Andrieu,A Brêmond,F Clavel,B. Gairard,J. Lansac,L. Piana,R. Renaud,S. R.P. Fine,H. R. Cuevas,P. Ontiveros,A. Palet,S. B. Salazar,N. Aristizabel,A. Cuadros,A. Bachelot,M. G. Lê,J. Deacon,Julian Peto,C. N. Taylor,E. Alfandary,Baruch Modan,Elaine Ron,Gary D. Friedman,Robert A. Hiatt,T. Bishop,J. Kosmelj,M. Primic-Zakelj,B. Ravnihar,J. Stare,W. L. Beeson,Graeme Fraser,D. S. Allen,R. D. Bulbrook,Jack Cuzick,I. S. Fentiman,J. L. Hayward,De Yun Wang,R. L. Hanson,M. C. Leske,Martin C. Mahoney,P. C. Nasca,A. O. Varma,A. L. Weinstein,Torgil Möller,Håkan Olsson,Jonas Ranstam,R.A. Goldbohm,P.A. van den Brandt,R. A. Apelo,J. Baens,J. R. de la Cruz,B. Javier,L. B. Lacaya,Corazon A. Ngelangel,C. La Vecchia,Eva Negri,Ettore Marubini,Monica Ferraroni,Mariette Gerber,Sylvia Richardson,C. Segala,D. Gatei,P. Kenya,A. Kungu,J. G. Mati,Louise A. Brinton,Robert N. Hoover,Catherine Schairer,Robert Spirtas,H. P. Lee,Matti A. Rookus,F. V. van Leeuwen,J. A. Schoenberg,Marilie D. Gammon,E. A. Clarke,Lee W. Jones,Klim McPherson,A. Neil,M. Vessey,D. Yeates,Valerie Beral,Diana Bull,B. Crossley,C Hermon,Simon Jones,Timothy J. Key,Claire E. Lewis,Gillian K Reeves,Pete Smith,Rory Collins,Richard Doll,Richard Peto,P. Hannaford,Kay Cr,Luis Rosero-Bixby,Y. T. Gao,Jian-Min Yuan,H. Y. Wei,T. Yun,C. Zhiheng,G. Berry,J Cooper Booth,T. Jelihovsky,Robert MacLennan,R. Shearman,Q. S. Wang,C. J. Baines,Anthony B. Miller,C. Wall,Eiliv Lund,H. Stalsberg,A. Dabancens,L. Martinez,R. Molina,O. Salas,Freda E. Alexander,B. S. Hulka,C. E. D. Chilvers,Leslie Bernstein,Robert W. Haile,Annlia Paganini-Hill,M. C. Pike,R. K. Ross,Giske Ursin,Mimi C. Yu,Hans-Olov Adami,Reinhold Bergström,M. P. Longnecker,Polly A. Newcomb,T. M.N. Farley,S. Holck,O. Meirik +188 more
TL;DR: Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53297 women with breast cancer and 100239 women without breast cancer from 54 epidemiological studies as mentioned in this paper.
Journal Article
Canadian National Breast Screening Study: 1. Breast cancer detection and death rates among women aged 40 to 49 years
TL;DR: Screening with yearly mammography and physical examination of the breasts detected considerably more node-negative, small tumours than usual care, but it had no impact on the rate of death from breast cancer up to 7 years' follow-up from entry.
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