Journal ArticleDOI
Brownian dynamics simulations of the recognition of the scorpion toxin P05 with the small-conductance calcium-activated potassium channels.
Meng Cui,Jianhua Shen,James M. Briggs,Wei Fu,Jingjiang Wu,Yingmin Zhang,Xiaomin Luo,Zhengwu Chi,Ruyun Ji,Hualiang Jiang,Kaixian Chen +10 more
TLDR
The consistency between the results of the BD simulations and the experimental data indicated that the 3D model of the P05-rsk2 channel complex is reasonable and can be employed in further biological studies, such as rational design of the novel therapeutic agents blocking the small-conductance, calcium-activated and apamin-sensitive potassium channels, and for mutagenesis studies in both toxins and SK channels.About:
This article is published in Journal of Molecular Biology.The article was published on 2002-04-26. It has received 36 citations till now. The article focuses on the topics: SK channel & Calcium-activated potassium channel.read more
Citations
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Journal ArticleDOI
Current views on scorpion toxins specific for K+-channels.
TL;DR: The evolutionary tree indicates that several clusters of divergent peptides show preference for specific subtypes of channels, and four different interacting modes were identified to exist between scorpion toxins and the various sub types of K+-channels.
Journal ArticleDOI
Novel interactions between K+ channels and scorpion toxins.
TL;DR: Recent data on the three-dimensional structures of K(+) channels and novel scorpion toxins suggest a variety of novel interacting modes of these channels and toxins, which should help increase the understanding of the K(+, channel structure-function relationship.
Journal ArticleDOI
Use of Venom Peptides to Probe Ion Channel Structure and Function
TL;DR: This minireview highlights molecular details of their toxin-receptor interactions and opportunities for development of peptide therapeutics.
Journal ArticleDOI
Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles.
Mats A.L. Eriksson,Benoît Roux +1 more
TL;DR: A combination of computational methods and structural analysis permits the identification of two possible structural models of AgTx2 in complex with the Shaker K+ channel, additional structural analysis providing further evidence in favor of a single model.
Journal ArticleDOI
Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels.
TL;DR: Psalmotoxin 1 (PcTx1), the first potent and specific blocker of the ASIC1a proton‐sensing channel, has been successfully expressed in the Drosophila melanogaster S2 cell recombinant expression system used here for the first time to produce a spider toxin.
References
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Journal ArticleDOI
Clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
TL;DR: The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved and modifications are incorporated into a new program, CLUSTAL W, which is freely available.
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The Protein Data Bank
Helen M. Berman,John D. Westbrook,Zukang Feng,Gary L. Gilliland,Talapady N. Bhat,Helge Weissig,Ilya N. Shindyalov,Philip E. Bourne +7 more
TL;DR: The goals of the PDB are described, the systems in place for data deposition and access, how to obtain further information and plans for the future development of the resource are described.
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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity
Declan A. Doyle,João H.Morais Cabral,Richard A. Pfuetzner,Anling Kuo,Jacqueline M. Gulbis,Steven L. Cohen,Brian T. Chait,Roderick MacKinnon +7 more
TL;DR: The architecture of the pore establishes the physical principles underlying selective K+ conduction, which promotes ion conduction by exploiting electrostatic repulsive forces to overcome attractive forces between K+ ions and the selectivity filter.
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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.
TL;DR: It is demonstrated in this work that the surface tension, water‐organic solvent, transfer‐free energies and the thermodynamics of melting of linear alkanes provide fundamental insights into the nonpolar driving forces for protein folding and protein binding reactions.
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LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
TL;DR: The LIGPLOT program automatically generates schematic 2-D representations of protein-ligand complexes from standard Protein Data Bank file input giving a simple and informative representation of the intermolecular interactions and their strengths, including hydrogen bonds, hydrophobic interactions and atom accessibilities.