Building a Centriole
TLDR
Centrioles are the key foundation of centrosomes and cilia, yet a molecular understanding of how they form has only recently begun to emerge and two interacting proteins are involved in controlling the timing of centriole templating of the cilium.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2013-02-01 and is currently open access. It has received 138 citations till now. The article focuses on the topics: Procentriole & Centriole.read more
Citations
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Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization
Vito Mennella,Bettina Keszthelyi,Kent L. McDonald,Bryant B. Chhun,F Kan,Gregory C. Rogers,Bo Huang,David A. Agard +7 more
TL;DR: It is demonstrated that the pericentriolar material is organized into two main structural domains: a layer juxtaposed to the centriole wall, and proteins extending farther away from the Centrosome organized in a matrix, using SIM and STORM subdiffraction-resolution microscopies.
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Once and only once: mechanisms of centriole duplication and their deregulation in disease
Erich A. Nigg,Andrew J. Holland +1 more
TL;DR: A better understanding of the molecular mechanisms governing centriole biogenesis is understood, opening up new possibilities for targeting these pathways in the context of human disease.
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Structural basis of the 9-fold symmetry of centrioles.
Daiju Kitagawa,Ioannis Vakonakis,Ioannis Vakonakis,Natacha Olieric,Manuel Hilbert,Debora Keller,Vincent Olieric,Miriam Bortfeld,Michèle C. Erat,Isabelle Flückiger,Pierre Gönczy,Michel O. Steinmetz +11 more
TL;DR: It is demonstrated that the centriolar protein SAS-6 forms rod-shaped homodimers that interact through their N-terminal domains to form oligomers, which establish that such oligomerization is essential for centriole formation in C. elegans and human cells.
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Regulating the transition from centriole to basal body.
TL;DR: Recent findings have begun to shed light on pathways that regulate the conversion of centrioles to basal bodies and vice versa, and provide insights into how defects in the balance between centrosome and cilia function could promote ciliopathies and cancer.
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Structured illumination of the interface between centriole and peri-centriolar material.
Jingyan Fu,David M. Glover +1 more
TL;DR: Structured illumination microscopy reveals in Drosophila that, before clouds of PCM appear, its proteins are closely associated with interphase centrioles in two tube-like layers: an inner layer occupied by centriolar microtubules, Sas-4, Spd-2 and Polo kinase; and an outer layer comprising Pericentrin-like protein (Dplp), Asterless (Asl) and Plk4 kinase.
References
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Plk4-Induced Centriole Biogenesis in Human Cells
Julia Kleylein-Sohn,Jens Westendorf,Mikael Le Clech,Robert Habedanck,York-Dieter Stierhof,Erich A. Nigg +5 more
TL;DR: It is shown that overexpression of Polo-like kinase 4 (Plk4) in human cells induces centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole, and that centrioles elongate through insertion of alpha-/beta-tubulin underneath a CP110 cap.
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Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division
TL;DR: It is shown that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the Drosophila male germ line.
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Cep97 and CP110 suppress a cilia assembly program.
TL;DR: P purified complexes associated with CP110, a protein that plays an essential role in centrosome duplication and cytokinesis, are purified and a previously uncharacterized protein, Cep97, that recruits CP110 to centrosomes is identified.
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Re-evaluating centrosome function.
TL;DR: A growing body of evidence indicates that centrosomes might not be essential for spindle assembly, whereas recent data indicate that they might be important for initiating S phase and completing cytokinesis.
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Centriole assembly in Caenorhabditis elegans
TL;DR: In this paper, the authors show that centriole assembly is triggered by an upstream signal mediated by SPD-2 and ZYG-1 proteins, and further define a structural pathway for the assembly of daughter centrioles in other organisms.