Journal ArticleDOI
Carfilzomib alleviated osteoporosis by targeting PSME1/2 to activate Wnt/β-catenin signaling
TLDR
Wang et al. as mentioned in this paper found that protein levels of proteasome activator subunit 1/2 (PSME1/2) increased in osteoporosis and accumulated mostly in osteoblasts and osteoclasts.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 2022-01-01. It has received 5 citations till now. The article focuses on the topics: Wnt signaling pathway & Osteoclast.read more
Citations
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Engineering BPQDs/PLGA nanospheres-Integrated Wood Hydrogel Bionic Scaffold for Combinatory Bone Repair and Osteolytic Tumor Therapy
Zhi Chao Hu,Jiaqi Lu,Annan Hu,Yongjiang Dou,Sheng Wei Wang,Dihan Su,Wang Ding,R. Lian,Shunyi Lu,Lan Xiao,Yulin Li,Jian Dong,Jian Zhou,Xuyong Yang,Libo Jiang +14 more
TL;DR: In this paper , a highly strong delignified wood/regenerated silk fibroin (RSF) hydrogel scaffold integrated with black phosphorus quantum dots (BPQDs) encapsulated by poly (lactic-co-glycolic acid) (PLGA) was engineered to realize efficient mechanical supporting, bone regeneration, and tumor therapy.
Journal ArticleDOI
Titanium Nanobowl-Based Nest-Like Nanofiber Structure Prepared at Room Temperature and Pressure Promotes Osseointegration of Beagle Implants
TL;DR: In this paper , nest-like nanofiber structures were prepared on a titanium surface at room temperature and pressure by using the nanobowl template-assisted method combined with alkali etching.
Journal ArticleDOI
Biocompatibility of a Ti-Rich Medium-Entropy Alloy with Glioblastoma Astrocytoma Cells
W F Ho,Ka-Kin Wong,Mei-Hwa Lee,James L. Thomas,Ya-chun Chang,Shih-Ching Wu,Hsueh-Chuan Hsu,Hung-Yin Lin +7 more
TL;DR: In this article , the authors compared the relative protein expression in cellular proliferation pathways with mRNA expression assessed with quantitative real-time reverse transcription polymerase chain reaction assay (qRT-PCR).
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An efficient metal-organic framework-based drug delivery platform for synergistic antibacterial activity and osteogenesis.
TL;DR: In this article , a metal-organic framework (MOF) based drug delivery platform was used to modify titanium implants for improved clinical applicability, and RNA sequencing and Western blotting analysis revealed that the coating activated the canonical Wnt/β-catenin signaling pathway through the regulation of tumor necrosis factor (TNF) pathway, thereby promoting the osteogenic differentiation of the human bone mesenchymal stem cells (hBMSCs).
Journal ArticleDOI
Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing
TL;DR: The role of miRNAs and genes that contribute to the regulation of normal growth and maintenance of skeletal muscle in response to short-term BCAA starvation stress has been investigated in this article , where the transcriptome and small RNAome sequencing of carp skeletal muscle were performed.
References
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Journal ArticleDOI
The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
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Wnt/β-catenin signaling: components, mechanisms, and diseases
TL;DR: Some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis are highlighted, and potential therapeutic implications are discussed.
Journal ArticleDOI
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Kazuhisa Nakashima,Xin Zhou,Gary R. Kunkel,Zhaoping Zhang,Jian Min Deng,Richard R. Behringer,Benoit de Crombrugghe +6 more
TL;DR: It is proposed that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells, because Osx null preostEoblasts express typical chondrocyte marker genes, and Osx acts downstream of Runx 2/C bfa1.
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Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation
Donald A. Glass,Peter Bialek,Jong Deok Ahn,Michael Starbuck,Millan S. Patel,Hans Clevers,Mark M. Taketo,Fanxin Long,Andrew P. McMahon,Richard A. Lang,Gerard Karsenty +10 more
TL;DR: Findings demonstrate that beta-catenin, and presumably Wnt signaling, promote the ability of differentiated osteoblasts to inhibit osteoclast differentiation and broaden the knowledge of the functions Wnt proteins have at various stages of skeletogenesis.
Journal ArticleDOI
Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression
Tripti Gaur,Christopher J. Lengner,Hayk Hovhannisyan,Ramesh A. Bhat,Peter V.N. Bodine,Barry S. Komm,Amjad Javed,Andre J. van Wijnen,Janet L. Stein,Gary S. Stein,Jane B. Lian +10 more
TL;DR: It is proposed that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-β signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development.