Journal ArticleDOI
CD147-mediated chemotaxis of CD4 + CD161 + T cells may contribute to local inflammation in rheumatoid arthritis
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TLDR
It was found that the percentage of CD4+CD161+ T cells and their expression of CD147 and CD98 in SF were higher than in the peripheral blood of RA patients, implying that the accumulation ofCD4+ CD161+T cells in SF and their high expression ofCD147 may be associated with CypA-mediated chemotaxis and contribute to local inflammation in RA.Abstract:
CD161 is used as a surrogate marker for Th17 cells, which are implicated in the pathogenesis of rheumatoid arthritis (RA). In this study, we evaluated the percentage, clinical significance, and CD98 and CD147 expression of CD4+CD161+ T cells. The potential role of CD147 and CD98 in cyclophilin A-induced chemotaxis of CD4+CD161+ T cells was analyzed. Thirty-seven RA patients, 15 paired synovial fluid (SF) of RA, and 22 healthy controls were recruited. The cell populations and surface expression of CD98 and CD147 were analyzed by flow cytometry. Spearman's rank correlation coefficient and multiple linear regression were applied to calculate the correlations. Chemotaxis assay was used to investigate CD4+CD161+ T cell migration. We found that the percentage of CD4+CD161+ T cells and their expression of CD147 and CD98 in SF were higher than in the peripheral blood of RA patients. Percentage of SF CD4+CD161+ T cells was positively correlated with 28-Joint Disease Activity Score (DAS28). CD147 monoclonal antibody (HAb18) attenuated the chemotactic ability of CD4+CD161+ T cells. An increased CD4+CD161+ T cell percentage and expression of CD147 and CD98 were shown in RA SF. Percentage of SF CD4+CD161+ T cells can be used as a predictive marker of disease activity in RA. CD147 block significantly decreased the chemotactic index of CD4+CD161+ cells induced by cyclophilin A (CypA). These results imply that the accumulation of CD4+CD161+ T cells in SF and their high expression of CD147 may be associated with CypA-mediated chemotaxis and contribute to local inflammation in RA.read more
Citations
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References
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Journal Article
Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes.
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Journal ArticleDOI
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
Melanie A. Kleinschek,Katia Boniface,Svetlana Sadekova,Jeff Grein,Erin Murphy,Scott P. Turner,Lisa Raskin,Bela Desai,William A. Faubion,Rene de Waal Malefyt,Robert H. Pierce,Terrill K. McClanahan,Robert A. Kastelein +12 more
TL;DR: The data identify CD161+ CD4 T cells as a resting Th17 pool that can be activated by IL-23 and mediate destructive tissue inflammation.
Journal ArticleDOI
CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC
Laura Maggi,Veronica Santarlasci,Manuela Capone,Anna Julie Peired,Francesca Frosali,Sarah Q. Crome,Valentina Querci,Massimiliano Fambrini,Francesco Liotta,Megan K. Levings,Enrico Maggi,Lorenzo Cosmi,Sergio Romagnani,Francesco Annunziato +13 more
TL;DR: Evidence is provided that umbilical cord blood naïve CD4+CD161− T cells, upon lentivirus‐mediated transduction with RORC2 can acquire the ability to express IL‐23R, IL‐1RI, and CD161, as well as to produce IL‐17.