Journal ArticleDOI
CD151 Amplifies Signaling by Integrin α6β1 to PI3K and Induces the Epithelial–Mesenchymal Transition in HCC Cells
Ai-Wu Ke,Guo-Ming Shi,Jian Zhou,Xiao-Yong Huang,Ying Hong Shi,Zhen-Bin Ding,Xiaoying Wang,Ranjan Prasad Devbhandari,Jia Fan +8 more
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TLDR
High expression levels of CD151 and α6 promote invasiveness of HCC cells, and either of these proteins, or PI3K signaling, might be targets for therapeutics for subgroups of patients with HCC.About:
This article is published in Gastroenterology.The article was published on 2011-05-01. It has received 154 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & PI3K/AKT/mTOR pathway.read more
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Role of epithelial to mesenchymal transition in hepatocellular carcinoma
TL;DR: Some aspects of EMT are still elusive and further studies are required to better link the clinical management of HCC with biomarkers and targeted therapies related to EMT, as well as explaining the current limiting insights into EMT by snapshot analyses of H CC tissues.
Journal ArticleDOI
Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling.
Pingzhao Zhang,Kaimi Li,Ying-Hao Shen,Ping-Ting Gao,Zhao-Ru Dong,Jia-Bing Cai,Caiyan Zhang,Xiao-Yong Huang,Tian Mx,Zhibin Hu,Dong-Mei Gao,Jiajun Fan,Ai-Wu Ke,Guo-Ming Shi +13 more
TL;DR: Clinically, the data suggest that Gal-1 may be a potential therapeutic target for HCC and a biomarker for predicting response to sorafenib treatment and the role and molecular mechanism ofGal-1 activity in hepatocellular carcinoma remain enigmatic.
Journal ArticleDOI
Circular RNA circTRIM33–12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression
Peng-Fei Zhang,Chuan-Yuan Wei,Xiao-Yong Huang,Rui Peng,Xuan Yang,Jia-Cheng Lu,Chi Zhang,Chao Gao,Jia-Bin Cai,Ping-Ting Gao,Dong-Mei Gao,Guo-Ming Shi,Ai-Wu Ke,Jia Fan +13 more
TL;DR: The important role of circTRIM33–12 in the proliferation, migration, invasion and immune evasion abilities of HCC cells is revealed and a new perspective on circRNAs in HCC progression is provided.
Journal ArticleDOI
LncRNA SNHG3 induces EMT and sorafenib resistance by modulating the miR-128/CD151 pathway in hepatocellular carcinoma.
Peng-Fei Zhang,Peng-Fei Zhang,Fei Wang,Jing Wu,Yin Wu,Wei Huang,Dong Liu,Xiao-Yong Huang,Xue-Mei Zhang,Ai-Wu Ke +9 more
TL;DR: Clinically, data suggest that SNHG3 may be a novel therapeutic target and a biomarker for predicting response to sorafenib treatment of HCC, and increased SNHg3 expression is correlated with poor HCC survival outcomes and sorAFenib response.
Journal ArticleDOI
αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma
Xiao-Yong Huang,Ai-Wu Ke,Guo-Ming Shi,Xin Zhang,Chi Zhang,Ying-Hong Shi,Xiaoying Wang,Zhen-Bin Ding,Yong-Sheng Xiao,Jun Yan,Shuang-Jian Qiu,Jia Fan,Jian Zhou +12 more
TL;DR: Clinically, the data suggest that the αB‐Crystallin‐14‐3‐3ζ complex acts synergistically to promote HCC progression by constitutively activating ERK signaling, and a biomarker for predicting sorafenib treatment response.
References
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Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
Journal ArticleDOI
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition
TL;DR: It is shown that GSK-3β binds to and phosphorylates Snail at two consensus motifs to dually regulate the function of this protein and together function as a molecular switch for many signalling pathways that lead to EMT.
Journal ArticleDOI
Integrin signalling during tumour progression.
Wenjun Guo,Filippo G. Giancotti +1 more
TL;DR: During progression from tumour growth to metastasis, specific integrin signals enable cancer cells to detach from neighbouring cells, re-orientate their polarity during migration, and survive and proliferate in foreign microenvironments.
Journal ArticleDOI
Tetraspanin functions and associated microdomains.
TL;DR: Important new genetic evidence has now emerged, and is bolstered by new insights into the cell biology, signalling and biochemistry of tetraspanins, that provide a framework for better understanding of these mysterious molecules in the regulation of cellular processes.