Cerebellar-Prefrontal Network Connectivity and Negative Symptoms in Schizophrenia
Roscoe O. Brady,Irene Gonsalvez,Ivy Lee,Dost Öngür,Larry J. Seidman,Jeremy D. Schmahmann,Shaun M. Eack,Matcheri S. Keshavan,Alvaro Pascual-Leone,Mark A. Halko +9 more
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TLDR
It is demonstrated that a connectivity breakdown between the cerebellum and the right dorsolateral prefrontal cortex is associated with negative symptom severity and that correction of this breakdown amelioratesnegative symptom severity, supporting a novel network hypothesis for medication-refractory negative symptoms and suggesting that network manipulation may establish causal relationships between network markers and clinical phenomena.Abstract:
Objective:The interpretability of results in psychiatric neuroimaging is significantly limited by an overreliance on correlational relationships. Purely correlational studies cannot alone determine...read more
Citations
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The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper
Georgios P. D. Argyropoulos,Kim van Dun,Michael Adamaszek,Maria Leggio,Mario Manto,Marcella Masciullo,Marco Molinari,Catherine J. Stoodley,Frank Van Overwalle,Richard B. Ivry,Jeremy D. Schmahmann +10 more
TL;DR: The paper substantiates the concept of CCAS with recent evidence from different scientific angles, promotes awareness of the CCAS as a clinical entity, and examines the current insight into the therapeutic options available.
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Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis
TL;DR: Using single-cell gene expression profiling and anatomical circuit analyses of vermis output neurons in the mouse fastigial (medial cerebellar) nucleus, five major classes of glutamatergic projection neurons are identified distinguished by gene expression, morphology, distribution, and input-output connectivity.
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Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits
Elyza Kelly,Fan-Tao Meng,Hirofumi Fujita,Felipe Morgado,Yasaman Kazemi,Laura C. Rice,Chongyu Ren,Christine Ochoa Escamilla,Jennifer M. Gibson,Sanaz Sajadi,Robert J. Pendry,Tommy Tan,Jacob Ellegood,M. Albert Basson,Randy D. Blakely,Scott V. Dindot,Christelle Golzio,Maureen K. Hahn,Nicholas Katsanis,Diane M. Robins,Jill L. Silverman,Karun K. Singh,Rachel Wevrick,Margot J. Taylor,Christopher Hammill,Evdokia Anagnostou,Brad E. Pfeiffer,Catherine J. Stoodley,Jason P. Lerch,Jason P. Lerch,Sascha du Lac,Peter T. Tsai +31 more
TL;DR: Two cerebellum–thalamus–mPFC pathways in mice that regulate social and repetitive behavior are described, raising the possibility that these circuits might provide neuromodulatory targets for the treatment of ASD.
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Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia.
TL;DR: The review summarizes the recent advances in the field, addressing the relevance of emerging new targets in schizophrenia in particular in relation to the dopamine – glutamate NMDA systems interactions.
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Consensus Paper. Cerebellar Reserve: From Cerebellar Physiology to Cerebellar Disorders.
Hiroshi Mitoma,Annalisa Buffo,Francesca Gelfo,Xavier Guell,Xavier Guell,E. Fucà,E. Fucà,Shinji Kakei,Jongho Lee,Mario Manto,Laura Petrosini,Aasef G. Shaikh,Jeremy D. Schmahmann +12 more
TL;DR: Cerebellar reserve, and the underlying plasticity of cerebellar microcircuitry that enables it, may be of critical neurobiological importance to a wide range of neurological/neuropsychiatric conditions.
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B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
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Jonathan D. Power,Alexander L. Cohen,Steven M. Nelson,Gagan S. Wig,Kelly Anne Barnes,Jessica A. Church,Alecia C. Vogel,Timothy O. Laumann,F.M. Miezin,Bradley L. Schlaggar,Steven E. Petersen +10 more
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