Journal ArticleDOI
Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study
Henryk Barthel,Hermann-Josef Gertz,Stefan Dresel,Oliver Peters,Peter Bartenstein,Katharina Buerger,Florian Hiemeyer,Sabine M Wittemer-Rump,John Seibyl,Cornelia Reininger,Osama Sabri +10 more
TLDR
The diagnostic efficacy of the scans was established in differentiating between patients with probable disease and age-matched healthy controls on the basis of neocortical tracer uptake pattern 90-110 min post-injection and the sensitivity and specificity of florbetaben (¹⁸F) PET was assessed.Abstract:
Summary Background Imaging with amyloid-β PET can potentially aid the early and accurate diagnosis of Alzheimer's disease. Florbetaben ( 18 F) is a promising 18 F-labelled amyloid-β-targeted PET tracer in clinical development. We aimed to assess the sensitivity and specificity of florbetaben ( 18 F) PET in discriminating between patients with probable Alzheimer's disease and elderly healthy controls. Methods We did a multicentre, open-label, non-randomised phase 2 study in 18 centres in Australia, Germany, Switzerland, and the USA. Imaging with florbetaben ( 18 F) PET was done on patients with probable Alzheimer's disease (age 55 years or older, mini-mental state examination [MMSE] score=18–26, clinical dementia rating [CDR]=0·5–2·0) and age-matched healthy controls (MMSE ≥28, CDR=0). Our primary objective was to establish the diagnostic efficacy of the scans in differentiating between patients with probable disease and age-matched healthy controls on the basis of neocortical tracer uptake pattern 90–110 min post-injection. PET images were assessed visually by three readers masked to the clinical diagnosis and all other clinical findings, and quantitatively by use of pre-established brain volumes of interest to obtain standard uptake value ratios (SUVRs), taking the cerebellar cortex as the reference region. This study is registered with ClinicalTrials.gov, number NCT00750282. Findings 81 participants with probable Alzheimer's disease and 69 healthy controls were assessed. Independent visual assessment of the PET scans showed a sensitivity of 80% (95% CI 71–89) and a specificity of 91% (84–98) for discriminating participants with Alzheimer's disease from healthy controls. The SUVRs in all neocortical grey-matter regions in participants with Alzheimer's disease were significantly higher (p r −0·27 to −0·33, p≤0·021). APOE ɛ4 was more common in participants with positive PET images compared with those with negative scans (65% vs 22% [p=0·027] in patients with Alzheimer's disease; 50% vs 16% [p=0·074] in healthy controls). No safety concerns were noted. Interpretation We provide verification of the efficacy, safety, and biological relevance of florbetaben ( 18 F) amyloid-β PET and suggest its potential as a visual adjunct in the diagnostic algorithm of dementia. Funding Bayer Schering Pharma AG.read more
Citations
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18F-labeled 2-phenylbenzoheterocycles with chiral dihydroxyl side chains as β-amyloid imaging probes.
TL;DR: In vitro autoradiography studies validated the design, synthesis and bio-evaluation of 2-phenylbenzoheterocycles with chiral dihydroxyl side chains as β-amyloid (Aβ) imaging probes as a potential PET imaging probe for AD early diagnosis.
Journal ArticleDOI
The Role of Free and Cued Selective Reminding Test in Predicting [18F]Florbetaben PET Results in Mild Cognitive Impairment and Mild Dementia.
Marco Spallazzi,Giovanni Michelini,Federica Barocco,Francesca Dieci,Sandra Copelli,Giovanni Messa,Maura Scarlattei,Giovanni Pavesi,Livia Ruffini,Paolo Caffarra +9 more
TL;DR: FCSRT proved itself to be a valid tool in dementia diagnosis, also being able to correlate with amyloid pathology, and improved with immediate free recall and delayed free recall overall in the whole sample.
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Longitudinal amyloid cognitive composite in preclinical Alzheimer’s disease
Julia Roos,Jari Sorvisto +1 more
TL;DR: The Longitudinal Amyloid Cognitive Composite in Preclinical AD (LACPA) as mentioned in this paper is a composite score that can sensitively detect the amyloid-β-related cognitive trajectory of preclinical AD using Korean data.
Journal ArticleDOI
Can hippocampal subfield measures supply information that could be used to improve the diagnosis of Alzheimer’s disease?
Balaji Kannappan,Jan te Nijenhuis,Yu Yong Choi,Jang Jae Lee,Kyu Yeong Choi,Irena Balzekas,Ho Yub Jung,Youngshik Choe,Min-Kyung Song,Ji Yeon Chung,Jung-Min Ha,Seong-Min Choi,Hoowon Kim,Byeong C. Kim,Hang Joon Jo,Kun Ho Lee +15 more
TL;DR: In this article , the authors investigated if hippocampal subfield volume measured by structural imaging, could provide information, so that the diagnosis of Alzheimer's disease could be improved, and concluded that the hippocampal volumetric differences from structural imaging show promise for improving the diagnosis.
Patient and caregiver assessment of the benefits from the clinical use of amyloid PET imaging
Rafid Mustafa,Jared R. Brosch,Gil D. Rabinovici,Bradford C. Dickerson,Maria C. Carrillo,Bradley S. Glazier,Sujuan Gao,Martha Tierney,Keith N. Fargo,Mary Guerriero Austrom,Susan De Santi,David G. Clark,Liana G. Apostolova +12 more
TL;DR: Patients and caregivers supported the use of amyloid PET imaging in clinical practice and felt that the information would provide significant benefits particularly in terms of future planning.
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