Journal ArticleDOI
Chimeric stem cells
TLDR
A critical look at new data that underpin the last of these claims: the chimeric stem cell.About:
This article is published in Trends in Molecular Medicine.The article was published on 2001-04-01. It has received 20 citations till now.read more
Citations
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Journal ArticleDOI
Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity.
Luc Vallières,Paul E. Sawchenko +1 more
TL;DR: Bone marrow does supply the mature brain with new specialized cells, however, mesenchymal precursors neither adopt neural phenotypes nor contribute to cerebral vascular remodeling, and continuous traffic of macrophages across the blood–brain barrier provides a vehicle to introduce therapeutic genes into the nervous system.
Journal ArticleDOI
Stem cell plasticity — building the brain of our dreams
TL;DR: Focusing on the nervous system, the evidence that adult neural stem cells are highly plastic, and that other types of adult non-neural stem cells can generate neural progeny, is reviewed to provide a balanced view of the evidence.
Journal ArticleDOI
Neurons from stem cells: preventing an identity crisis.
TL;DR: The aim of this review is to discuss the various techniques that are used to identify a cell as a neuron.
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Adult stem cells—reprogramming neurological repair?
Claire M Rice,Neil J Scolding +1 more
TL;DR: Processes that might underlie apparent changes in adult cell phenotype are reviewed, with particular reference to neurology, and implications these processes might have for the development of new therapeutic strategies using adult stem cells are discussed.
Journal ArticleDOI
Large-scale expansion of mammalian neural stem cells: a review.
TL;DR: This review focuses on recent developments in expanding human and murine NSCs on a large scale, including the development of new serum-free media and bioreactor protocols and techniques for the evaluation of NSC characteristics.
References
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Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TL;DR: A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.
Journal ArticleDOI
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Eric Lagasse,Heather Connors,Muhsen Al-Dhalimy,Michael J. Reitsma,Monika Dohse,Linda Osborne,Xin Wang,Milton J. Finegold,Irving L. Weissman,Markus Grompe +9 more
TL;DR: It is reported that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver.
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Stem cells: units of development, units of regeneration, and units in evolution.
TL;DR: The review begins with a detailed examination of hematopoi-via the umbilical vein to the fetal liver between dpc 8.5 etic (blood-forming) stem cells, and the transcription pro-The earliest stem cells in ontogeny are totipotent, ex- files of each of these populations are quite distinct.
Journal ArticleDOI
Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow
TL;DR: It is shown that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens.