Journal ArticleDOI
Chitosan: a versatile biopolymer for orthopaedic tissue-engineering.
TLDR
The ability to manipulate and reconstitute tissue structure and function using chitosan has tremendous clinical implications and is likely to play a key role in cell and gene therapies in coming years.About:
This article is published in Biomaterials.The article was published on 2005-10-01. It has received 1500 citations till now. The article focuses on the topics: Intervertebral disk & Tissue engineering.read more
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
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On the mechanisms of biocompatibility.
TL;DR: It is shown that, in the vast majority of circumstances, the sole requirement for biocompatibility in a medical device intended for long-term contact with the tissues of the human body is that the material shall do no harm to those tissues, achieved through chemical and biological inertness.
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Chitosan and its derivatives for tissue engineering applications.
In Yong Kim,Seog Jin Seo,Hyun Seuk Moon,Mi Kyong Yoo,In Young Park,Bom Chol Kim,Chong-Su Cho +6 more
TL;DR: This review focuses on the various types of chitosan derivatives and their use in various tissue engineering applications namely, skin, bone, cartilage, liver, nerve and blood vessel.
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Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications
TL;DR: A wide range of natural-origin polymers with special focus on proteins and polysaccharides that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue engineering field targeting several biological tissues are overviewed.
References
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Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering : a review
TL;DR: Some biomaterials, which have been suggested to promote chondrogenesis and to have potentials for tissue engineering of articular cartilage, are reviewed and a new biomaterial, a chitosan-based polysaccharide hydrogel, is introduced and discussed in terms of the biocompatibility with chondrocytes.
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Implantable applications of chitin and chitosan
Eugene Khor,Lee Yong Lim +1 more
TL;DR: This review surveys select works of key groups in Asia developing chitin and chitosan materials for implantable biomedical applications and finds Japan has been the undisputed leader, but other Asian nations, namely Korea, Singapore, Taiwan and Thailand have also made notable contributions.
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Porous chitosan scaffolds for tissue engineering
TL;DR: The methods and structures described here provide a starting point for the design and fabrication of a family of polysaccharide based scaffold materials with potentially broad applicability in several tissue-relevant geometries.
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Novel injectable neutral solutions of chitosan form biodegradable gels in situ
Abdellatif Chenite,C Chaput,Dadong Wang,C Combes,Michael D. Buschmann,Caroline D. Hoemann,Jean-Christophe Leroux,B.L Atkinson,F Binette,A Selmani +9 more
TL;DR: This study reports for the first time the use of polymer/polyol salt aqueous solutions as gelling systems, suggesting the discovery of a prototype for a new family of thermosetting gels highly compatible with biological compounds.
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Evaluation of the biocompatibility of a chitosan scaffold in mice.
Pamela J. VandeVord,Howard W. T. Matthew,Stephen P. DeSilva,Lois Mayton,Bin Wu,Paul H. Wooley +5 more
TL;DR: It is suggested that chitosan may be suitable for the development of implantable materials after a preliminary study showed a high degree of biocompatibility in this animal model.