Clinical and pathophysiologic relevance of autoantibodies in rheumatoid arthritis.
Sara de Brito Rocha,Danielle Cristiane Baldo,Luis Eduardo Coelho Andrade +2 more
- Vol. 59, Iss: 1, pp 2-2
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TLDR
The characterization of a comprehensive array of novel autoantibody systems in RA will provide unique pathogenic insights of relevance for the development of diagnostic and prognostic approaches compatible with an effective personalized medicine.Abstract:
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disease affecting 0.5 to 1% of adults worldwide and frequently leads to joint destruction and disability. Early diagnosis and early and effective therapy may prevent joint damage and lead to better long-term results. Therefore, reliable biomarkers and outcome measures are needed. Refinement of the understanding of molecular pathways involved in disease pathogenesis have been achieved by combining knowledge on RA-associated genes, environmental factors and the presence of serological elements. The presence of autoantibodies is a distinctive feature of RA. Rheumatoid Factor and Anti-Citrullinated Protein Antibodies are the two most remarkable autoantibodies in RA and provide different clinical and pathophysiological information. They precede the onset of disease symptoms and predict a more severe disease course, indicating a pathogenetic role in RA. Therefore, they promote a more accurate prognosis and contribute for a better disease management. Several RA-associated autoantibody systems have been identified: Anti-Carbamylated Antibodies, Anti-BRAF, Anti-Acetylated, Anti-PAD4 antibodies and others. Hopefully, the characterization of a comprehensive array of novel autoantibody systems in RA will provide unique pathogenic insights of relevance for the development of diagnostic and prognostic approaches compatible with an effective personalized medicine.read more
Citations
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Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
Gyrid Nygaard,Gary S. Firestein +1 more
TL;DR: An overview of advances in understanding of FLS biology is provided and omics approaches and studies that hold promise for identifying future therapeutic targets are highlighted.
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Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci.
TL;DR: The largest-ever trans-ancestral meta-analysis of rheumatoid arthritis (RA) has been performed, identifying 11 new RA susceptibility loci that explained 6.9% and 1.8% of the single-nucleotide polymorphism-based heritability in East Asians and Europeans, respectively.
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Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies
Anna-Lena Mueller,Zahra Payandeh,Niloufar Mohammadkhani,Shaden M.H. Mubarak,Alireza Zakeri,Armina Alagheband Bahrami,Aranka Brockmueller,Mehdi Shakibaei +7 more
TL;DR: In this paper, a review of the latest RA research findings are discussed to better understand the pathogenesis, and finally, treatment strategies for RA therapy are presented, including both conventional approaches and new methods that have been developed in recent years or are currently under investigation.
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Current view on the pathogenic role of anti-citrullinated protein antibodies in rheumatoid arthritis.
TL;DR: In this article, the authors summarized recent data on the functional properties of patient-derived anti-citrullinated protein antibodies (ACPAs) and presented mechanistic models on how these antibodies might contribute to RA pathogenesis.
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Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis.
TL;DR: The diagnostic value of autoantibodies, their synthesis and function as a mediator of joint inflammation, and the significance of IgG-Fc glycosylation are discussed.
References
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Journal ArticleDOI
2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.
Daniel Aletaha,Tuhina Neogi,Alan J. Silman,Julia Funovits,David T. Felson,Clifton O. Bingham,Neal S. Birnbaum,Gerd Burmester,Vivian P. Bykerk,Marc D. Cohen,Bernard Combe,Karen H. Costenbader,Maxime Dougados,Paul Emery,Gianfranco Ferraccioli,Johanna M. W. Hazes,Kathryn Hobbs,Tom W J Huizinga,Arthur Kavanaugh,Jonathan Kay,Tore K Kvien,Timothy J. Laing,Philip J. Mease,Henri A Ménard,Larry W. Moreland,Raymond L. Naden,Theodore Pincus,Josef S Smolen,Ewa Stanislawska-Biernat,Deborah P M Symmons,Paul P. Tak,Katherine S. Upchurch,Jiří Vencovský,Frederick Wolfe,Gillian A. Hawker +34 more
TL;DR: This new classification system redefines the current paradigm of RA by focusing on features at earlier stages of disease that are associated with persistent and/or erosive disease, rather than defining the disease by its late-stage features.
Journal ArticleDOI
2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.
Daniel Aletaha,Tuhina Neogi,Alan J. Silman,Julia Funovits,David T. Felson,Clifton O. Bingham,Neal S. Birnbaum,Gerd Burmester,Vivian P. Bykerk,Marc D. Cohen,Bernard Combe,Karen H. Costenbader,Maxime Dougados,Paul Emery,Gianfranco Ferraccioli,Johanna M. W. Hazes,Kathryn Hobbs,Tom W J Huizinga,Arthur Kavanaugh,Jonathan Kay,Tore K Kvien,Timothy J. Laing,Philip J. Mease,Henri A Ménard,Larry W. Moreland,Raymond L. Naden,Theodore Pincus,Josef S Smolen,Ewa Stanislawska-Biernat,Deborah P M Symmons,Paul P. Tak,Katherine S. Upchurch,Jiří Vencovský,Frederick Wolfe,Gillian A. Hawker +34 more
TL;DR: This new classification system redefines the current paradigm of RA by focusing on features at earlier stages of disease that are associated with persistent and/or erosive disease, rather than defining the disease by its late-stage features.
Journal ArticleDOI
Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors
M M J Nielen,Dirkjan van Schaardenburg,Henk W. Reesink,Rob J. Van De Stadt,Irene E. van der Horst-Bruinsma,Margret H. M. T. De Koning,Moud R. Habibuw,Jan P. Vandenbroucke,Ben A. C. Dijkmans +8 more
TL;DR: In this article, the authors investigated the time course for the development of antibodies before onset of clinical RA and found that approximately half of patients with RA have specific serologic abnormalities several years before the onset of symptoms.
Journal ArticleDOI
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Shimin Zhao,Wei Xu,Wenqing Jiang,Wei Yu,Yan Lin,Tengfei Zhang,Jun Yao,Li Zhou,Yaxue Zeng,Hong Li,Yixue Li,Jiong Shi,Wenlin An,Susan M. Hancock,Fuchu He,Lunxiu Qin,Jason W. Chin,Pengyuan Yang,Xian Chen,Xian Chen,Qun-Ying Lei,Yue Xiong,Yue Xiong,Kun-Liang Guan +23 more
TL;DR: It is revealed that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism, and plays a major role in metabolic regulation.
Journal ArticleDOI
Lysine acetylation: codified crosstalk with other posttranslational modifications
TL;DR: This review focuses on recent findings pertinent to acetylation of nonhistone proteins and emphasizes how this modification might crosstalk with phosphorylation, methylation, ubiquitination, sumoylation, and others to form code-like multisite modification programs for dynamic control of cellular signaling under diverse conditions.
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