Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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TLDR
Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.About:
This article is published in The Lancet.The article was published on 2020-03-28 and is currently open access. It has received 20189 citations till now. The article focuses on the topics: Cohort study & Retrospective cohort study.read more
Citations
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Racial Disparities in Incidence and Outcomes Among Patients With COVID-19
L. Silvia Munoz-Price,Ann B. Nattinger,Frida Rivera,Ryan Hanson,Cameron G. Gmehlin,Adriana Pérez,Siddhartha Singh,Blake W. Buchan,Nathan A. Ledeboer,Liliana E. Pezzin +9 more
TL;DR: The results of this study indicate that in the first weeks of the COVID-19 pandemic in Milwaukee, Wisconsin, Black race was associated with a positive CO VID-19 test and the subsequent need for hospitalization, but only poverty wasassociated with intensive care unit admission.
Journal ArticleDOI
COVID-19: don't neglect antimicrobial stewardship principles!
Benedikt Huttner,Benedikt Huttner,Gaud Catho,José Ramón Paño-Pardo,Céline Pulcini,Jeroen Schouten +5 more
Journal ArticleDOI
Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases.
Marina Tadolini,Luigi Codecasa,José-María García-García,François-Xavier Blanc,Sergey Borisov,Jan-Willem C. Alffenaar,Jan-Willem C. Alffenaar,Claire Andrejak,Pierre Bachez,Pierre-Alexandre Bart,Evgeny Belilovski,José Cardoso-Landivar,Rosella Centis,Lia D'Ambrosio,Maria Luiza de Souza-Galvão,Ángel Domínguez-Castellano,Samir Dourmane,Mathilde Fréchet Jachym,Antoine Froissart,Vania Giacomet,Delia Goletti,Soazic Grard,Gina Gualano,Armine Izadifar,Damien Le Dû,Margarita Marín Royo,Jesica Mazza-Stalder,Ilaria Motta,Catherine W.M. Ong,Fabrizio Palmieri,Frédéric Rivière,Teresa Rodrigo,Denise Rossato Silva,Adrián Sánchez-Montalvá,Matteo Saporiti,Paolo Scarpellini,Frédéric Schlemmer,Antonio Spanevello,Elena Sumarokova,Eva Tabernero,Paul A. Tambyah,Simon Tiberi,Simon Tiberi,Alessandro Torre,Dina Visca,Miguel Zabaleta Murguiondo,Giovanni Sotgiu,Giovanni Battista Migliori +47 more
TL;DR: Diagnostic, treatment and outcome details of 49 COVID-19 patients with concurrent or previous tuberculosis from 8 countries show varied clinical profiles.
Journal ArticleDOI
A molecular single-cell lung atlas of lethal COVID-19.
Johannes C. Melms,Jana Biermann,Huachao Huang,Yiping Wang,Ajay Nair,Somnath Tagore,Igor Katsyv,André F. Rendeiro,Amit Dipak Amin,Denis Schapiro,Denis Schapiro,Chris J. Frangieh,Chris J. Frangieh,Adrienne M. Luoma,Aveline Filliol,Yinshan Fang,Hiranmayi Ravichandran,Mariano G. Clausi,George A. Alba,Meri Rogava,Sean W. Chen,Patricia Ho,Daniel T. Montoro,Daniel T. Montoro,Adam E. Kornberg,Arnold Han,Mathieu F. Bakhoum,Niroshana Anandasabapathy,Mayte Suárez-Fariñas,Samuel F. Bakhoum,Yaron Bram,Alain C. Borczuk,Xinzheng V. Guo,Jay H. Lefkowitch,Charles C. Marboe,Stephen M. Lagana,Armando Del Portillo,Emily J. Tsai,Emmanuel Zorn,Glen S. Markowitz,Robert F. Schwabe,Robert E. Schwartz,Olivier Elemento,Anjali Saqi,Hanina Hibshoosh,Jianwen Que,Benjamin Izar +46 more
TL;DR: In this paper, the authors performed single-nucleus RNA sequencing of about 116,000 nuclei from the lungs of nineteen individuals who died of COVID-19 and underwent rapid autopsy and seven control individuals.
Journal ArticleDOI
Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study.
Chao Gao,Yue Cai,Kan Zhang,Lei Zhou,Yao Zhang,Xijing Zhang,Qi Li,Weiqin Li,Shiming Yang,Xiaoyan Zhao,Yuying Zhao,Hui Wang,Yi Liu,Zhiyong Yin,Ruining Zhang,Rutao Wang,Ming Yang,Chen Hui,William Wijns,J William McEvoy,Osama Ibrahim Ibrahim Soliman,Yoshinobu Onuma,Patrick W. Serruys,Patrick W. Serruys,Ling Tao,Fei Li +25 more
TL;DR: While hypertension and the discontinuation of antihypertensive treatment are suspected to be related to increased risk of mortality, in this retrospective observational analysis, it did not detect any harm of RAAS inhibitors in patients infected with COVID-19.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more
TL;DR: The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
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Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
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