Journal ArticleDOI
Clinical findings in 111 cases of influenza A (H7N9) virus infection
Hainv Gao,Hongzhou Lu,Bin Cao,Bin Du,Hong Shang,Jianhe Gan,Shuihua Lu,Yida Yang,Qiang Fang,Yinzhong Shen,Xiuming Xi,Qin Gu,Xian-Mei Zhou,Hong-Ping Qu,Zheng Yan,Fang-Ming Li,Wei Zhao,Zhancheng Gao,Guang-Fa Wang,Lingxiang Ruan,Weihong Wang,Jun Ye,Hui-Fang Cao,Xingwang Li,Wenhong Zhang,Xu-Chen Fang,Jian He,Weifeng Liang,Juan Xie,Mei Zeng,Xianzheng Wu,Jun Li,Qi Xia,Zhao-Chen Jin,Qi Chen,Chao Tang,Zhiyong Zhang,Bao-Min Hou,Zhi-Xian Feng,Jifang Sheng,Nanshan Zhong,Lanjuan Li +41 more
TLDR
The presence of a coexisting medical condition was the only independent risk factor for the acute respiratory distress syndrome (ARDS) during the evaluation period, and the novel H7N9 virus caused severe illness, including pneumonia and ARDS, with high rates of ICU admission and death.Abstract:
Background During the spring of 2013, a novel avian-origin influenza A (H7N9) virus emerged and spread among humans in China. Data were lacking on the clinical characteristics of the infections caused by this virus. Methods Using medical charts, we collected data on 111 patients with laboratory-confirmed avian-origin influenza A (H7N9) infection through May 10, 2013. Results Of the 111 patients we studied, 76.6% were admitted to an intensive care unit (ICU), and 27.0% died. The median age was 61 years, and 42.3% were 65 years of age or older; 31.5% were female. A total of 61.3% of the patients had at least one underlying medical condition. Fever and cough were the most common presenting symptoms. On admission, 108 patients (97.3%) had findings consistent with pneumonia. Bilateral ground-glass opacities and consolidation were the typical radiologic findings. Lymphocytopenia was observed in 88.3% of patients, and thrombocytopenia in 73.0%. Treatment with antiviral drugs was initiated in 108 patients (97.3%)...read more
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Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.
Yan Rong Guo,Qing Dong Cao,Zhong Si Hong,Yuan Yang Tan,Shoudeng Chen,Hong Jun Jin,Kai Sen Tan,De Yun Wang,Yan Yan +8 more
TL;DR: The latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19 are summarized, and the current treatment and scientific advancements to combat the epidemic novel coronavirus are discussed.
Journal ArticleDOI
Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis.
Wei Jie Guan,Wenhua Liang,Yi Zhao,Heng Rui Liang,Zi Sheng Chen,Yimin Li,Xiaoqing Liu,Ru Chong Chen,Chun Li Tang,Tao Wang,Chun-Quan Ou,Li Li,Ping Yan Chen,Ling Sang,Wei Wang,Jianfu Li,Caichen Li,Li Min Ou,Bo Cheng,Shan Xiong,Zheng Yi Ni,Jie Xiang,Yu Hu,Lei Liu,Hong Shan,Chun Liang Lei,Yi Xiang Peng,Li Wei,Yong Liu,Ya Hua Hu,Peng Peng,Jian-ming Wang,Ji Yang Liu,Zhong Chen,Gang Li,Zhi Jian Zheng,Shao Qin Qiu,Jie Luo,Chang Jiang Ye,Shao Yong Zhu,Lin Ling Cheng,Feng Ye,Shi Yue Li,Jin Ping Zheng,Nuo Fu Zhang,Nanshan Zhong,Jianxing He +46 more
TL;DR: It is found that among laboratory confirmed cases of COVID-19, patients with any comorbidity yielded poorer clinical outcomes than those without and a greater number ofComorbidities also correlated with poorer clinical outcome.
References
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Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
Journal ArticleDOI
Influenza-associated hospitalizations in the United States.
William W. Thompson,David K. Shay,Eric Weintraub,Lynnette Brammer,Carolyn B. Bridges,Nancy J. Cox,Keiji Fukuda +6 more
TL;DR: Significant numbers of influenza-associated hospitalizations in the United States occur among the elderly, and the numbers of these hospitalizations have increased substantially over the last 2 decades due in part to the aging of the population.
Journal ArticleDOI
Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more
TL;DR: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died.
Journal ArticleDOI
Avian influenza A (H5N1) infection in humans
John H. Beigel,Jeremy Farrar,Aye Maung Han,Frederick G. Hayden,Randy Hyer,Menno D. de Jong,Sorasak Lochindarat,Thi Kim Tien Nguyen,Tran Hien Nguyen,Tinh Hien Tran,Angus Nicoll,Sok Touch,Kwok-Yung Yuen +12 more
TL;DR: The writing committee consisted of the following: John H. Beigel, M.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md, and Jeremy Farrar, D.Phil., Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Journal ArticleDOI
Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome
Yu Chen,Weifeng Liang,Shigui Yang,Nanping Wu,Hainv Gao,Jifang Sheng,Hangping Yao,Jianer Wo,Qiang Fang,Dawei Cui,Yongcheng Li,Xing Yao,Yun-Tao Zhang,Haibo Wu,Shufa Zheng,Hongyan Diao,Shichang Xia,Yanjun Zhang,Kwok-Hung Chan,Hoi-Wah Tsoi,Jade Lee-Lee Teng,Wenjun Song,Pui Wang,Siu-Ying Lau,Min Zheng,Jasper Fuk-Woo Chan,Kelvin K. W. To,Honglin Chen,Lanjuan Li,Kwok-Yung Yuen +29 more
TL;DR: Cross species poultry-to-person transmission of this new reassortant H7N9 virus is associated with severe pneumonia and multiorgan dysfunction in human beings and monitoring of the viral evolution and further study of disease pathogenesis will improve disease management, epidemic control, and pandemic preparedness.
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