Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
John W. Devlin,John W. Devlin,Yoanna Skrobik,Céline Gélinas,Dale M. Needham,Arjen J. C. Slooter,Pratik P. Pandharipande,Paula L. Watson,Gerald L. Weinhouse,Mark E. Nunnally,Bram Rochwerg,Michele C. Balas,Mark van den Boogaard,Karen J. Bosma,Karen J. Bosma,Nathaniel E. Brummel,Gerald Chanques,Linda Denehy,Xavier Drouot,Gilles L. Fraser,Jocelyn E. Harris,Aaron M. Joffe,Michelle E. Kho,John P. Kress,Julie A. Lanphere,Sharon McKinley,Karin J. Neufeld,Margaret A. Pisani,Jean François Payen,Brenda T. Pun,Kathleen Puntillo,Richard R. Riker,Bryce R.H. Robinson,Yahya Shehabi,Paul M. Szumita,Chris Winkelman,John Centofanti,Carrie Price,Sina Nikayin,Cheryl Misak,Pamela Flood,Ken Kiedrowski,Waleed Alhazzani +42 more
TLDR
Substantial agreement was found among a large, interdisciplinary cohort of international experts regarding evidence supporting recommendations, and the remaining literature gaps in the assessment, prevention, and treatment of Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) in critically ill adults.Abstract:
Objective:To update and expand the 2013 Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the ICU.Design:Thirty-two international experts, four methodologists, and four critical illness survivors met virtually at least monthly. All section groups gread more
Citations
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Care for Critically Ill Patients With COVID-19.
TL;DR: The COVID-19 Treatment Guidelines Panel recommends using an N95 respirator (or equivalent or higher-level respirator) rather than surgical masks, in addition to other personal protective equipment (PPE) (i.e., gloves, gown, and eye protection such as a face shield or safety goggles).
Journal ArticleDOI
Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults.
Brenda T. Pun,Michele C. Balas,Michele C. Balas,Mary Ann Barnes-Daly,Jennifer L. Thompson,J. Matthew Aldrich,Juliana Barr,Juliana Barr,Diane G. Byrum,Shannon S. Carson,John W. Devlin,Heidi J. Engel,Cheryl L. Esbrook,Ken D. Hargett,Lori Harmon,Christina Hielsberg,James C. Jackson,Tamra Kelly,Vishakha K. Kumar,Lawson Millner,Alexandra Morse,Christiane Perme,Patricia Posa,Kathleen Puntillo,William D. Schweickert,Joanna L. Stollings,Alai Tan,Lucy D'Agostino McGowan,E. Wesley Ely +28 more
TL;DR: ABCDEF bundle performance showed significant and clinically meaningful improvements in outcomes including survival, mechanical ventilation use, coma, delirium, restraint-free care, ICU readmissions, and post-ICU discharge disposition.
Journal ArticleDOI
Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients
Eric M. Liotta,Ayush Batra,Jeffrey R. Clark,Nathan A. Shlobin,Steven C. Hoffman,Zachary S. Orban,Igor J. Koralnik +6 more
TL;DR: This work sought to characterize the neurologic manifestations, their risk factors, and associated outcomes in hospitalized patients with Covid‐19.
Journal ArticleDOI
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness
Timothy D. Girard,Matthew C. Exline,Shannon S. Carson,Catherine L. Hough,Peter Rock,Michelle N. Gong,Ivor S. Douglas,Atul Malhotra,Robert L. Owens,Daniel J Feinstein,Babar A. Khan,Margaret A. Pisani,Robert C. Hyzy,Gregory A. Schmidt,William D. Schweickert,R. Duncan Hite,David L. Bowton,Andrew L. Masica,Jennifer L. Thompson,Rameela Chandrasekhar,Rameela Chandrasekhar,Brenda T. Pun,Cayce Strength,Cayce Strength,Leanne M. Boehm,James C. Jackson,Pratik P. Pandharipande,Nathan E. Brummel,Christopher G. Hughes,Mayur B. Patel,Joanna L. Stollings,Gordon R. Bernard,Robert S. Dittus,E. Wesley Ely,Mind-Usa Investigators +34 more
TL;DR: The use of haloperidol or ziprasidone, as compared with placebo, in patients with acute respiratory failure or shock and hypoactive or hyperactive delirium in the ICU did not significantly alter the duration of delirity.
Journal ArticleDOI
Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study.
Brenda T. Pun,Rafael Badenes,Gabriel Heras La Calle,Onur M Orun,Wencong Chen,Rameela Raman,Beata-Gabriela K Simpson,Stephanie Wilson-Linville,Borja Hinojal Olmedillo,Ana Vallejo de la Cueva,Mathieu van der Jagt,Rosalía Navarro Casado,Pilar Leal Sanz,Günseli Orhun,Carolina Ferrer Gómez,Karla Núñez Vázquez,Patricia Piñeiro Otero,Fabio Silvio Taccone,Elena Gallego Curto,Anselmo Caricato,Hilde Wøien,Guillaume Lacave,Hollis R. O’Neal,Sarah J. Peterson,Nathan E. Brummel,Nathan E. Brummel,Timothy D. Girard,Timothy D. Girard,E. Wesley Ely,Pratik P. Pandharipande,Jacques Creteur,Elisa Govea Bogossian,Lorenzo Peluso,Felipe González-Seguel,Viviane Hidalgo-Calibin,Pablo Carreño-Montenegro,Verónica Rojas,Eduardo Tobar,Antonio Ramírez-Palma,Karen Herrera-Davis,Alexis Ferré,Stéphane Legriel,Thomas Godet,Ugo Fraisse,Bruno Gonçalves,Aurélien Mazeraud,Myrto Tzimou,Frank Rasulo,Silvia Beretta,Mattia Marchesi,Chiara Robba,Denise Battaglini,Paolo Pelosi,Anna Teresa Mazzeo,Alberto Noto,Giuseppe Servillo,Annachiara Marra,Salvatore Lucio Cutuli,Gabriele Pintaudi,Eleonora Stival,Eloisa Sofia Tanzarella,Erik Roman-Pognuz,Chiara Maria Concetta Massaro,Muhammed Elhadi,Lisa Smit,Theresa Olasveengen,Isabel Jesus Pereira,Carla Margarida Teixeira,Alice Santos,Miguel Valente,Cristina Granja,Rita Pereia,João Manoel Silva,Blanca Furquet,Mónica García Simón,Daniel A Godoy Torres,Berta Monleón,Esteban Morcillo,Nekane Romero,Ainhoa Serrano,Sara Torrico Sánchez,Francisco Luis Pérez Caballero,Isabel Peña Luna,Ignacio Baeza Gómez,Milagros Calizaya Vargas,Jordi Morillas Pérez,Genís Carrasco Gómez,Ricard Molina Latorre,Sheila Moya Gutiérrez,Irene Patricia Barón Barrera,Cristina Delgado Palacios,Beatriz García Góngora,Laura Labrador Romero,Laura Galarza,Ignacio Catalán-Monzón,Enver Rodriguez-Martinez,Cristina Murcia Gubianas,Ariadna Bellès,María Esther Rodriguez Delgado,Jesús Caballero,Dulce Morales,Andrés Pujol,Jorge Rubio,Eva Álvarez Torres,Estefanía Carvajal Revuelta,Isabel de la Calle Gil,Blanca Fernández Tomás,Berta Gallego Rodríguez,Matilde González Serrano,Paloma LaTorre Andreu,Aris Pérez Lucendo,Elena Abril Palomares,Elena Gonzalez,María Cruz Martín Delgado,Carlos Muñoz De Cabo,Pablo T. Aznar,Carlos A. Calvo,Ignacio Garutti,Fernando Higuero,David Martínez-Gascueña,Emilio Maseda,Itziar Insausti,Ana Montero Feijoo,Alejandro Suarez-de-la-Rica,Beatriz Del Moral Barbudo,Yago García Blanco-Traba,Maria Claudia Giménez Santamarina,Alba Gonzalo Millán,Sergio Llorente Damas,David Pestaña Lagunas,Isabel Reyes García,Alejandro Ruiz Perea,Álvaro Ortega Guerrero,María Jesús Mármol Cubillo,David Díaz Muñoz,Silvia García de Castrillón i Ramal,Xavier Andorrà Sunyer,María de las Nieves Noci Moreno,Rosa María Pérez Manrique,Emilio del Campo Molina,María Elena Martínez Quintana,Sol Fernandez-Gonzalo,Gemma Gomà Fernández,Guillem Navarra-Ventura,Anna Baró Serra,Cristina Fuster,Oriol Plans Galván,Diana Gil-Castillejos,Mario Dalorzo González,Francisco Javier Morán Gallego,Irene Paredes Borrachero,Patricia Rodríguez Villamizar,Juan Romeu Prieto,María José Sánchez Carretero,Susana Gallardo Sánchez,Filadelfo Bustos Molina,María Luisa García Pérez,Paula Castello-Mora,Jaume Puig,María Rosa Sanchis-Martin,Carmen Andrea Sanchis-Veryser,María Pilar Vicente-Fernández,Rafael Zaragoza,Laura Lizama,Irene Torres,Cristina Álvarez,Paula Ramirez,Meri Martin Cerezuela,M. Montero,Jose García Cantos,Paola Valls,Nerea Aretxabala Cortajarena,Pablo García Domelo,Laura González Cubillo,Marta Martín Martínez,Inés Pérez Francisco,Yolanda Poveda Hernández,Amaia Quintano Rodero,César Rodriguez Nuñez,Martin Siegemund,Anna Estermann,Núria Zellweger,Imen Ben Saida,Mohamed Boussarsar,Figen Esen,Perihan Ergin Özcan,Christopher Berkey,Christine Harb,Morgan H. Tandy,Ellis Morgan,Karen Shephard,Robert C. Hyzy,Michael T. Kenes,Kristine Nelson,Robert E. Hosse,Katie M. Vance,C. Adrian Austin,Aaron Lerner,Emily Sanders,Robert A Balk,David A Bennett,Andrew R. Vogel,Lucia Chowdhury,Kiran Devulapally,Michelle Woodham,Sarah Cohen,Nihal Patel,Catherine M. Kuza,Mandeep Sing,Spencer Roberson,Kelly Drumright,Sameep Sehgal,Sara C. LaHue,Vanja C. Douglas,Aarti Sarwal +214 more
TL;DR: In this paper, the authors investigated the prevalence of delirium and coma, and risk factors for delirius in critically ill patients with COVID-19, to aid the development of strategies to mitigate delirious and associated sequelae.
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Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit
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