Construction of implantation failure related lncRNA-mRNA network and identification of lncRNA biomarkers for predicting endometrial receptivity.
TLDR
An implantation failure related lncRNA-mRNA network is constructed, and six key lncRNAs and their ceRNA sub-networks are identified, which were involved in immunological activity, growth factor binding, vascular proliferation, apoptosis and steroid biosynthesis in uterus and prepared endometrium for embryo implantation.Citations
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Epigenetic modifications working in the decidualization and endometrial receptivity.
TL;DR: This review will focus on the epigenetic modifications in decidualization and open novel avenues to predict and treat the pregnancy complications caused by abnormal decidUALization.
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Identification of Key lncRNAs Associated With Atherosclerosis Progression Based on Public Datasets.
TL;DR: Bioinformatics analysis revealed these lncRNAs were involved in regulating the leukotriene biosynthetic process, gene expression, actin filament organization, t-circle formation, antigen processing, and presentation, interferon-gamma-mediated signaling pathway, and activation of GTPase activity.
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Long noncoding RNA CYTOR sponges miR-195 to modulate proliferation, migration, invasion and radiosensitivity in nonsmall cell lung cancer cells
Jun Zhang,Wenqi Li +1 more
TL;DR: It is found that CYTOR promoted cell proliferation, migration and invasion ability, and induced radioresistance in NSCLC cells, and CYTOR may be used as a promising therapeutic target forNSCLC treatment.
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Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes.
Juan Chen,Juan Xu,Yongsheng Li,Jinwen Zhang,Hong Chen,Jianping Lu,Zishan Wang,Xueying Zhao,Kang Xu,Yixue Li,Xia Li,Yan Zhang +11 more
TL;DR: This study identified 29 critical subtype-specific ceRNA hubs that characterized the different breast cancer subtypes and provides new insight into the common and specific subtype ceRNA interactions that define the different categories of breast cancer.
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Endometrial extracellular vesicles from women with recurrent implantation failure attenuate the growth and invasion of embryos.
TL;DR: Endometrial EVs from patients with RIF attenuate the development and invasion of embryos and the invasion capacity of hatched embryos decreased significantly in the RIF-EV group.
References
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Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie,Belinda Phipson,Di Wu,Yifang Hu,Charity W. Law,Wei Shi,Gordon K. Smyth,Gordon K. Smyth +7 more
TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
TL;DR: It is proposed that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
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miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions.
Chih Hung Chou,Sirjana Shrestha,Chi Dung Yang,Chi Dung Yang,Nai-Wen Chang,Yu Ling Lin,Kuang-Wen Liao,Wei Chi Huang,Ting Hsuan Sun,Siang Jyun Tu,Wei Hsiang Lee,Wei Hsiang Lee,Men Yee Chiew,Chun San Tai,Ting-Yen Wei,Tzi Ren Tsai,Hsin Tzu Huang,Chung Yu Wang,Hsin Yi Wu,Shu Yi Ho,Pin Rong Chen,Cheng Hsun Chuang,Pei Jung Hsieh,Yi Shin Wu,Wen-Liang Chen,Meng Ju Li,Meng Ju Li,Yu Chun Wu,Xin Yi Huang,Fung Ling Ng,Waradee Buddhakosai,Pei Chun Huang,Kuan Chun Lan,Chia-Yen Huang,Shun Long Weng,Yeong Nan Cheng,Chao Liang,Wen-Lian Hsu,Hsien Da Huang +38 more
TL;DR: An updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles is described, which serves as more comprehensively annotated, experimentally validated miRNA-target interactions databases in the field of miRNA related research.
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Interferon Gamma in Successful Pregnancies
TL;DR: The dynamic roles of IFNG in successful pregnancy is described and data onIFNG in gestational pathologies is summarized.