Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
Randy L. Buckner,Jorge Sepulcre,Tanveer Talukdar,Fenna M. Krienen,Hesheng Liu,Trey Hedden,Jessica R. Andrews-Hanna,Reisa A. Sperling,Keith A. Johnson +8 more
Reads0
Chats0
TLDR
To identify regions of high connectivity in the human cerebral cortex, a computationally efficient approach was applied to map the degree of intrinsic functional connectivity across the brain and explored whether the topography of hubs could explain the pattern of vulnerability in Alzheimer's disease (AD).Abstract:
Recent evidence suggests that some brain areas act as hubs interconnecting distinct, functionally specialized systems. These nexuses are intriguing because of their potential role in integration and also because they may augment metabolic cascades relevant to brain disease. To identify regions of high connectivity in the human cerebral cortex, we applied a computationally efficient approach to map the degree of intrinsic functional connectivity across the brain. Analysis of two separate functional magnetic resonance imaging datasets (each n = 24) demonstrated hubs throughout heteromodal areas of association cortex. Prominent hubs were located within posterior cingulate, lateral temporal, lateral parietal, and medial/lateral prefrontal cortices. Network analysis revealed that many, but not all, hubs were located within regions previously implicated as components of the default network. A third dataset (n = 12) demonstrated that the locations of hubs were present across passive and active task states, suggesting that they reflect a stable property of cortical network architecture. To obtain an accurate reference map, data were combined across 127 participants to yield a consensus estimate of cortical hubs. Using this consensus estimate, we explored whether the topography of hubs could explain the pattern of vulnerability in Alzheimer's disease (AD) because some models suggest that regions of high activity and metabolism accelerate pathology. Positron emission tomography amyloid imaging in AD (n = 10) compared with older controls (n = 29) showed high amyloid-beta deposition in the locations of cortical hubs consistent with the possibility that hubs, while acting as critical way stations for information processing, may also augment the underlying pathological cascade in AD.read more
Citations
More filters
Journal ArticleDOI
An Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection
Daphne J. Holt,Brittany S. Cassidy,Jessica R. Andrews-Hanna,Su Mei Lee,Garth Coombs,Donald C. Goff,John D. E. Gabrieli,Joseph M. Moran +7 more
TL;DR: In this paper, the authors found that patients with schizophrenia show dysfunction of the medial prefrontal cortex during self-reflection and that this abnormal activity is associated with changes in the strength of resting-state correlations between these regions.
Journal ArticleDOI
Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition.
Ethan A. Solomon,James E. Kragel,Michael R. Sperling,Ashwini Sharan,Greg Worrell,Michal T. Kucewicz,Cory S. Inman,Bradley C. Lega,Kathryn A. Davis,Joel M. Stein,Barbara C. Jobst,Kareem A. Zaghloul,Sameer A. Sheth,Daniel S. Rizzuto,Michael J. Kahana +14 more
TL;DR: It is reported that gamma networks desynchronize and theta networks synchronize during encoding and retrieval, establishing gamma as a largely asynchronous phenomenon.
Journal ArticleDOI
Differential neural activity in the recognition of old versus new events: an activation likelihood estimation meta-analysis.
TL;DR: Neural activity distinguishing old from new events comprises an ensemble of multiple memory‐specific activities, including encoding, retrieval, and priming, as well as multiple types of more general cognitive activities, such as default‐mode, cognitive‐control, and reward processing.
Journal ArticleDOI
In defense of abstract conceptual representations
TL;DR: The evidence supports a hierarchical model of knowledge representation in which modal systems provide a mechanism for concept acquisition and serve to ground individual concepts in external reality, whereas broadly conjunctive, supramodal representations play an equally important role in concept association and situation knowledge.
Journal ArticleDOI
The effects of antidepressant treatment on resting-state functional brain networks in patients with major depressive disorder.
Li Wang,Mingrui Xia,Mingrui Xia,Ke Li,Yawei Zeng,Yun-Ai Su,Wenji Dai,Qinge Zhang,Zhen Jin,Philip B. Mitchell,Xin Yu,Yong He,Yong He,Tian-Mei Si +13 more
TL;DR: In this article, the functional connectivity strength (FCS) was analyzed using a graph-theory approach to determine treatment-related changes in the whole brain connectivity of major depressive disorder patients.
References
More filters
Journal ArticleDOI
Collective dynamics of small-world networks
TL;DR: Simple models of networks that can be tuned through this middle ground: regular networks ‘rewired’ to introduce increasing amounts of disorder are explored, finding that these systems can be highly clustered, like regular lattices, yet have small characteristic path lengths, like random graphs.
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Book
Social Network Analysis: Methods and Applications
TL;DR: This paper presents mathematical representation of social networks in the social and behavioral sciences through the lens of Dyadic and Triadic Interaction Models, which describes the relationships between actor and group measures and the structure of networks.
Journal ArticleDOI
The Psychophysics Toolbox.
TL;DR: The Psychophysics Toolbox is a software package that supports visual psychophysics and its routines provide an interface between a high-level interpreted language and the video display hardware.
Journal ArticleDOI
Centrality in social networks conceptual clarification
TL;DR: In this article, three distinct intuitive notions of centrality are uncovered and existing measures are refined to embody these conceptions, and the implications of these measures for the experimental study of small groups are examined.
Related Papers (5)
Complex brain networks: graph theoretical analysis of structural and functional systems
Edward T. Bullmore,Olaf Sporns +1 more