Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
Randy L. Buckner,Jorge Sepulcre,Tanveer Talukdar,Fenna M. Krienen,Hesheng Liu,Trey Hedden,Jessica R. Andrews-Hanna,Reisa A. Sperling,Keith A. Johnson +8 more
Reads0
Chats0
TLDR
To identify regions of high connectivity in the human cerebral cortex, a computationally efficient approach was applied to map the degree of intrinsic functional connectivity across the brain and explored whether the topography of hubs could explain the pattern of vulnerability in Alzheimer's disease (AD).Abstract:
Recent evidence suggests that some brain areas act as hubs interconnecting distinct, functionally specialized systems. These nexuses are intriguing because of their potential role in integration and also because they may augment metabolic cascades relevant to brain disease. To identify regions of high connectivity in the human cerebral cortex, we applied a computationally efficient approach to map the degree of intrinsic functional connectivity across the brain. Analysis of two separate functional magnetic resonance imaging datasets (each n = 24) demonstrated hubs throughout heteromodal areas of association cortex. Prominent hubs were located within posterior cingulate, lateral temporal, lateral parietal, and medial/lateral prefrontal cortices. Network analysis revealed that many, but not all, hubs were located within regions previously implicated as components of the default network. A third dataset (n = 12) demonstrated that the locations of hubs were present across passive and active task states, suggesting that they reflect a stable property of cortical network architecture. To obtain an accurate reference map, data were combined across 127 participants to yield a consensus estimate of cortical hubs. Using this consensus estimate, we explored whether the topography of hubs could explain the pattern of vulnerability in Alzheimer's disease (AD) because some models suggest that regions of high activity and metabolism accelerate pathology. Positron emission tomography amyloid imaging in AD (n = 10) compared with older controls (n = 29) showed high amyloid-beta deposition in the locations of cortical hubs consistent with the possibility that hubs, while acting as critical way stations for information processing, may also augment the underlying pathological cascade in AD.read more
Citations
More filters
Journal ArticleDOI
The Functional Architecture of the Infant Brain as Revealed by Resting-State fMRI
TL;DR: Results are presented showing that cortical hubs and their associated cortical networks are largely confined to primary sensory and motor brain regions in the infant brain and suggest that the functional network architecture in infants is linked to support tasks that are of a perception-action nature.
Journal ArticleDOI
Eigenvector centrality mapping for analyzing connectivity patterns in fMRI data of the human brain.
Gabriele Lohmann,Daniel S. Margulies,Annette Horstmann,Burkhard Pleger,Joeran Lepsien,Dirk Goldhahn,Haiko Schloegl,Michael Stumvoll,Arno Villringer,Robert Turner +9 more
TL;DR: The analyses demonstrate that eigenvector centrality is a computationally efficient tool for capturing intrinsic neural architecture on a voxel-wise level and applications based on linear correlations and on spectral coherences between fMRI times series are presented.
Journal ArticleDOI
Mapping distributed brain function and networks with diffuse optical tomography
Adam T. Eggebrecht,Silvina L. Ferradal,Amy Robichaux-Viehoever,Mahlega S. Hassanpour,Hamid Dehghani,Abraham Z. Snyder,Tamara Hershey,Joseph P. Culver +7 more
TL;DR: A high-density diffuse optical tomography imaging array that can map higher-order, distributed brain function is presented and imaged brain function in patients with Parkinson's disease and implanted deep brain stimulators that preclude functional magnetic resonance imaging.
Journal ArticleDOI
Disrupted Axonal Fiber Connectivity in Schizophrenia
Andrew Zalesky,Alex Fornito,Alex Fornito,Marc L. Seal,Luca Cocchi,Carl-Fredrik Westin,Edward T. Bullmore,Gary F. Egan,Christos Pantelis +8 more
TL;DR: Evidence of widespread dysconnectivity in white-matter connectional architecture in a large sample of patients with schizophrenia is presented, pointing to a multifaceted pathophysiology in schizophrenia encompassing axonal as well as putative synaptic mechanisms.
Journal ArticleDOI
Energetic cost of brain functional connectivity.
TL;DR: A simple model for the energy demands of brain functional connectivity was tested with positron emission tomography and MRI in 54 healthy volunteers at rest and found that the energy efficiency of the connectivity hubs was higher for ventral precuneus, cerebellum, and subcortical hubs than for cortical hubs.
References
More filters
Journal ArticleDOI
Collective dynamics of small-world networks
TL;DR: Simple models of networks that can be tuned through this middle ground: regular networks ‘rewired’ to introduce increasing amounts of disorder are explored, finding that these systems can be highly clustered, like regular lattices, yet have small characteristic path lengths, like random graphs.
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Book
Social Network Analysis: Methods and Applications
TL;DR: This paper presents mathematical representation of social networks in the social and behavioral sciences through the lens of Dyadic and Triadic Interaction Models, which describes the relationships between actor and group measures and the structure of networks.
Journal ArticleDOI
The Psychophysics Toolbox.
TL;DR: The Psychophysics Toolbox is a software package that supports visual psychophysics and its routines provide an interface between a high-level interpreted language and the video display hardware.
Journal ArticleDOI
Centrality in social networks conceptual clarification
TL;DR: In this article, three distinct intuitive notions of centrality are uncovered and existing measures are refined to embody these conceptions, and the implications of these measures for the experimental study of small groups are examined.
Related Papers (5)
Complex brain networks: graph theoretical analysis of structural and functional systems
Edward T. Bullmore,Olaf Sporns +1 more