COVID-19 and Vaccination in the Setting of Neurologic Disease: An Emerging Issue in Neurology.
Elisabeth B. Marsh,Michael D. Kornberg,Kevin Kessler,Ihtsham Haq,Anup D. Patel,Avindra Nath,Becky Schierman,Lyell K. Jones +7 more
TLDR
In this paper, the authors reviewed the current literature, focusing on COVID-19 infection in adults with neurological disease, in order to elucidate risks and benefits of vaccination in these individuals.Abstract:
The COVID-19 pandemic caused by the SARS-CoV-2 virus has left many unanswered questions for patients with neurological disorders and the providers caring for them. Elderly and immunocompromised patients are at increased risk for severe symptoms due to COVID-19, and the virus may increase symptoms of underlying neurological illness, particularly for those with significant bulbar and respiratory weakness or other neurologic disability. Emerging SARS-CoV-2 vaccines offer substantial protection from symptomatic infection, but both patients and providers may have concerns regarding theoretical risks of vaccination, including vaccine safety and efficacy in the context of immunotherapy and the potential for precipitating or exacerbating neurological symptoms. In this statement on behalf of the Quality Committee of the AAN we review the current literature, focusing on COVID-19 infection in adults with neurological disease, in order to elucidate risks and benefits of vaccination in these individuals. Based on existing evidence, neurologists should recommend COVID-19 vaccination to their patients. For those patients being treated with immunotherapies, attention should be paid to timing of vaccination with respect to treatment and the potential for an attenuated immune response.read more
Citations
More filters
Journal ArticleDOI
Vaccination Against SARS-CoV-2 in Neuroinflammatory Disease: Early Safety/Tolerability Data
TL;DR: The most common reasons for hesitancy in NID participants were lack of testing in the autoimmune population and fear of demyelinating/neurologic events as mentioned in this paper .
Journal ArticleDOI
Reversible neurological and brain MRI changes following COVID-19 vaccination: A case report
Anuj Rastogi,Arina Bingeliene,Antonio P. Strafella,David F. Tang-Wai,P. Wu,Daniel M. Mandell +5 more
TL;DR: In this article , the authors describe the first case of untreated post COVID-19 vaccine encephalitis with spontaneous resolution of contrast enhancing hyperintensities on MRI concomitant with clinical improvement.
Journal ArticleDOI
The relationship between myasthenia gravis and COVID-19: a systematic review
TL;DR: In this article , a systematic literature finding was applied in 15 electronic scientific resources to assess and conclude the research-based study systematically to analyze the relationship of MG and COVID-19.
Journal ArticleDOI
Postvaccinal GABA‐B receptor antibody encephalitis after ChAdOx1 nCoV‐19 vaccination
TL;DR: A male patient who presented with generalized tonic‐clonic seizures, cognitive decline, and gait disturbance that occurred suddenly after the second dose of the ChAdOx1 nCoV‐19 vaccine was encountered, presumably due to transient autoantibody production following vaccine administration.
Journal ArticleDOI
Exacerbation of Pre-existing Neurological Symptoms With COVID-19 in Patients With Chronic Neurological Diseases: An Updated Systematic Review
Md Sakibuzzaman,Anid Hassan,Samira Hayee,Fariah Asha Haque,Sumaita Sadida Bushra,Maisha Maliha,Maksuda Khan Tania,Anahita Sadat,Fahima Akter,T. Mazumder,Joyeta Razzaque,Progga P. Kapuria,Ishra Jalal,Prince Shah-Riar +13 more
TL;DR: The relationship between pre-existing neurological disorders and CO VID-19 is documented, showing an increased risk of hospitalization, admission length, worsening of symptoms, and even mortality in COVID-19 patients.
References
More filters
Journal ArticleDOI
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Ling Mao,Huijuan Jin,Mengdie Wang,Yu Hu,Shengcai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Xiaoping Miao,Yanan Li,Bo Hu +12 more
TL;DR: During the epidemic period of COVID-19, clinicians should suspect severe acute respiratory syndrome coronavirus 2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and lose the chance to treat and prevent further transmission.
Journal ArticleDOI
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Lindsey R. Baden,Hana M. El Sahly,Brandon Essink,Karen L. Kotloff,Sharon E. Frey,Rick Novak,David Diemert,Stephen A. Spector,Nadine Rouphael,C. Buddy Creech,John W McGettigan,Shishir Khetan,Nathan Segall,Joel Solis,Adam Brosz,Carlos Fierro,Howard J. Schwartz,Kathleen M. Neuzil,Lawrence Corey,Peter B. Gilbert,Holly Janes,Dean Follmann,Mary A. Marovich,John R. Mascola,Laura Polakowski,Julie E. Ledgerwood,Barney S. Graham,Hamilton Bennett,Rolando Pajon,Conor Knightly,Brett Leav,Weiping Deng,Honghong Zhou,Shu Liang Han,Melanie Ivarsson,Jacqueline Miller,Tal Z Zaks +36 more
TL;DR: The mRNA-1273 vaccine as discussed by the authors is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19.
Journal ArticleDOI
mRNA vaccines — a new era in vaccinology
TL;DR: A detailed overview of mRNA vaccines is provided and future directions and challenges in advancing this promising vaccine platform to widespread therapeutic use are considered.
Journal ArticleDOI
Neurologic Features in Severe SARS-CoV-2 Infection.
Julie Helms,Stéphane Kremer,Hamid Merdji,Raphaël Clere-Jehl,Malika Schenck,Christine Kummerlen,Olivier Collange,Clotilde Boulay,Samira Fafi-Kremer,Mickaël Ohana,Mathieu Anheim,Ferhat Meziani +11 more
TL;DR: Neurologic Features in SARS-CoV-2 Infection In a consecutive series of 64 patients with Covid-19 and ARDS, 58 of whom underwent neurologic examination, severe agitation and corticospinal signs were found.
Journal ArticleDOI
Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.
Bina Choi,Manish Chandra Choudhary,James Regan,Jeffrey A. Sparks,Robert F. Padera,Xueting Qiu,Isaac H. Solomon,Hsiao Hsuan Kuo,Julie Boucau,Kathryn Bowman,U. Das Adhikari,Marisa L. Winkler,Alisa A. Mueller,Tiffany Y.T. Hsu,Michaël Desjardins,Lindsey R. Baden,Brian Chan,Bruce D. Walker,Mathias Lichterfeld,Manfred Brigl,Douglas S. Kwon,Sanjat Kanjilal,Eugene T Richardson,A. Helena Jonsson,Galit Alter,Amy K. Barczak,William P. Hanage,Xu G. Yu,Gaurav D. Gaiha,Michael S. Seaman,Manuela Cernadas,Jonathan Z. Li +31 more
TL;DR: An immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of treatment, is described.