Journal ArticleDOI
Current evidence on the effect of dietary polyphenols intake on chronic diseases
Chiara Costa,Aristidis Tsatsakis,Charalampos Mamoulakis,Michele Teodoro,Giusi Briguglio,Emanuela Caruso,Dimitris Tsoukalas,Denisa Margina,Efthimios Dardiotis,Demetrios Kouretas,Concettina Fenga +10 more
TLDR
This comprehensive review of the current evidence defining the position of polyphenols in the prevention/treatment of human chronic diseases, including prostate cancer and other types of cancer, cardiovascular diseases, diabetes mellitus and neurodegenerative diseases such as Alzheimer's and Parkinson's disease focuses on their ability to modulate multiple signalling transduction pathways involved in the pathophysiology of these diseases.About:
This article is published in Food and Chemical Toxicology.The article was published on 2017-12-01. It has received 184 citations till now. The article focuses on the topics: Health effects of natural phenols and polyphenols & Disease.read more
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Classification and diagnosis of diabetes
TL;DR: A diagnosis of gestational diabetes mellitus (GDM) (diabetes diagnosed in the second or third trimester of pregnancy that is not clearly overt diabetes) or chemical-induced diabetes (such as in the treatment of HIV/AIDS or after organ transplantation)
Journal ArticleDOI
Polyphenols: A concise overview on the chemistry, occurrence, and human health
Alessandra Durazzo,Massimo Lucarini,Eliana B. Souto,Eliana B. Souto,Carla Cicala,Elisabetta Caiazzo,Angelo A. Izzo,Ettore Novellino,Antonello Santini +8 more
TL;DR: This review gives an updated picture of each class of phenolic compounds and their properties and the use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.
Journal ArticleDOI
Obesity a risk factor for increased COVID19 prevalence, severity and lethality (Review).
Demetrios Petrakis,Denisa Margina,Konstantinos Tsarouhas,Fotios Tekos,Miriana Stan,Dragana Nikitovic,Demetrios Kouretas,Demetrios A. Spandidos,Aristidis Tsatsakis +8 more
TL;DR: A growing body of evidence connects obesity with COVID-19 and a number of mechanisms from immune system activity attenuation to chronic inflammation are implicated and Lipid peroxidation creates reactive lipid aldehydes which in a patient with metabolic disorder and CO VID-19 will affect its prognosis.
Journal ArticleDOI
Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis.
TL;DR: Emerging data suggest that polyphenols can regulate cellular lipid metabolism; vascular and endothelial function; haemostasis; as well as platelet function; which represent primary conditions for atherosclerotic plaque formation and development.
Journal ArticleDOI
The Akt pathway in oncology therapy and beyond (Review)
George Mihai Nitulescu,Maryna van de Venter,Georgiana Nitulescu,Anca Ungurianu,Petras Juzenas,Qian Peng,Octavian Tudorel Olaru,Daniela Gradinaru,Aristides M. Tsatsakis,Dimitris Tsoukalas,Demetrios A. Spandidos,Denisa Margina +11 more
TL;DR: This review presents key features of Akt structure and functions, and presents the progress ofAkt inhibitors in regards to drug development, and their preclinical and clinical activity in regard to therapeutic efficacy and safety for patients.
References
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Journal ArticleDOI
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
TL;DR: The GLOBOCAN series of the International Agency for Research on Cancer (IARC) as mentioned in this paper provides estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012.
Journal ArticleDOI
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
Guy M. McKhann,Guy M. McKhann,David S. Knopman,Howard Chertkow,Bradley T. Hyman,Clifford R. Jack,Claudia H. Kawas,William E. Klunk,Walter J. Koroshetz,Jennifer J. Manly,Richard Mayeux,Richard C. Mohs,John C. Morris,Martin N. Rossor,Philip Scheltens,Maria C. Carrillo,Bill Thies,Sandra Weintraub,Creighton H. Phelps +18 more
TL;DR: The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.