Current Use and Trends in Hematopoietic Cell Transplantation in the United States
Anita D'Souza,Anita D'Souza,Stephanie J. Lee,Stephanie J. Lee,Xiaochun Zhu,Marcelo C. Pasquini,Marcelo C. Pasquini +6 more
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TLDR
Key findings are fewer autologous transplants performed for non-Hodgkin lymphoma and increasing numbers of haploidentical transplants, nearly all of which use post-transplant cyclophosphamide for graft-versus-host disease prophylaxis.About:
This article is published in Biology of Blood and Marrow Transplantation.The article was published on 2017-09-01 and is currently open access. It has received 417 citations till now. The article focuses on the topics: Transplantation & Alemtuzumab.read more
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Diagnosis and Management of AML in Adults: 2022 ELN Recommendations from an International Expert Panel.
Hartmut Döhner,Andrew H. Wei,Frederick R. Appelbaum,Charles Craddock,Courtney D. DiNardo,Hervé Dombret,Benjamin L. Ebert,Pierre Fenaux,Lucy A. Godley,Robert P. Hasserjian,Richard A. Larson,Ross Levine,Yasushi Miyazaki,Dietger Niederwieser,Gert J. Ossenkoppele,Christoph Röllig,Jorge Sierra,Eytan M. Stein,Martin S. Tallman,Hwei-Fang Tien,Jianxiang Wang,Agnieszka Wierzbowska,Bob Löwenberg +22 more
TL;DR: This update includes a revised ELN genetic risk classification, revised response criteria, and treatment recommendations for acute myeloid leukemia in adults, which are widely recognized among physicians and investigators.
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Carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for patients with newly diagnosed multiple myeloma without intention for immediate autologous stem-cell transplantation (ENDURANCE): a multicentre, open-label, phase 3, randomised, controlled trial
Shaji Kumar,Susanna Jacobus,Adam D. Cohen,Matthias Weiss,Natalie S. Callander,Avina K. Singh,Terri L. Parker,Alexander R. Menter,Xuezhong Yang,Benjamin M. Parsons,Pankaj Kumar,Prashant Kapoor,Aaron S. Rosenberg,Jeffrey A. Zonder,Edward A. Faber,Sagar Lonial,Kenneth C. Anderson,Paul G. Richardson,Robert Z. Orlowski,Lynne I. Wagner,S. Vincent Rajkumar +20 more
TL;DR: This multicentre, open-label, phase 3, randomised controlled trial aimed to assess whether the KRd regimen is superior to the VRd regimen in the treatment of newly diagnosed multiple myeloma in patients who were not being considered for immediate autologous stem-cell transplantation (ASCT).
Journal ArticleDOI
COVID-19 in immunocompromised patients: A systematic review of cancer, hematopoietic cell and solid organ transplant patients.
Jennifer A. Belsky,Jennifer A. Belsky,Brian P. Tullius,Brian P. Tullius,Margaret G. Lamb,Margaret G. Lamb,Rouba Sayegh,Rouba Sayegh,Joseph Stanek,Jeffery J. Auletta +9 more
TL;DR: In this article, the authors evaluated the clinical impact of severe coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome (SARS-CoV-2), in immunocompromised patients and compared their clinical data and outcomes to the general population.
Journal ArticleDOI
The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update.
Xiao-Hui Zhang,Jing Chen,Mingzhe Han,He Huang,Erlie Jiang,Ming Jiang,Yongrong Lai,Dai-Hong Liu,Qifa Liu,Ting Liu,Hanyun Ren,Yongping Song,Zimin Sun,Xiaowen Tang,Jianmin Wang,Depei Wu,Lan-Ping Xu,Xi Zhang,Daobin Zhou,Xiao-Jun Huang,Xiao-Jun Huang +20 more
TL;DR: The consensus recommendations in 2018 from The Chinese Society of Hematology (CSH) on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation (allo-HSCT) facilitated the standardization of clinical practices of allo-HCT in China and progressive integration with the world as discussed by the authors.
Journal ArticleDOI
Double unrelated umbilical cord blood vs HLA-haploidentical bone marrow transplantation: the BMT CTN 1101 trial.
Ephraim J. Fuchs,Paul O'Donnell,Mary Eapen,Brent R. Logan,Joseph H. Antin,Peter Dawson,Steven M. Devine,Mary M. Horowitz,Mitchell E. Horwitz,Chatchada Karanes,Eric S. Leifer,John M. Magenau,Joseph P. McGuirk,Lawrence E. Morris,Andrew R. Rezvani,Richard J. Jones,Claudio G. Brunstein +16 more
TL;DR: While both donor sources extend access to reduced intensity transplantation, analyses of secondary endpoints, including overall survival, favor haploidentical bone marrow donors.
References
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Journal ArticleDOI
Defining the intensity of conditioning regimens: working definitions.
Andrea Bacigalupo,Karen K. Ballen,Doug Rizzo,Sergio Giralt,Hillard M. Lazarus,Vincent T. Ho,Jane F. Apperley,Shimon Slavin,Marcelo C. Pasquini,Brenda M. Sandmaier,John Barrett,Didier Blaise,Robert Lowski,Mary M. Horowitz +13 more
TL;DR: This report proposes to define conditioning regimens in 3 categories: (1) myeloablative (MA) conditioning, (2) reduced-intensity conditioning (RIC), and (3) nonmyeloablatives (NMA) Conditioning, based on the duration of cytopenia and on the requirement for stem cell support.
Journal ArticleDOI
Reduced-intensity conditioning regimen workshop: defining the dose spectrum. Report of a workshop convened by the center for international blood and marrow transplant research.
Sergio Giralt,Karen K. Ballen,Douglas Rizzo,Andreas Bacigalupo,Mary M. Horowitz,Marcelo C. Pasquini,Brenda M. Sandmaier +6 more
TL;DR: Although HCT professionals have not reached a consensus on what constitutes a RIC regimen, most accept currently used criteria and operational definitions, and these results support the continued use of current criteria for RIC regimens until a consensus statement can be developed.
Journal ArticleDOI
Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States
Lori Muffly,Marcelo C. Pasquini,Michael Martens,Ruta Brazauskas,Xiaochun Zhu,Kehinde Adekola,Mahmoud Aljurf,Karen K. Ballen,Ashish Bajel,Frédéric Baron,Minoo Battiwalla,Amer Beitinjaneh,Jean-Yves Cahn,Mathew Carabasi,Yi-Bin Chen,Saurabh Chhabra,Stefan O. Ciurea,Edward A. Copelan,Anita D'Souza,John R. Edwards,James M. Foran,Cesar O. Freytes,Henry C. Fung,Robert Peter Gale,Sergio Giralt,Shahrukh K. Hashmi,Gerhard C. Hildebrandt,Vincent T. Ho,Ann A. Jakubowski,Hillard M. Lazarus,Marlise R. Luskin,Rodrigo Martino,Richard T. Maziarz,Philip L. McCarthy,Taiga Nishihori,Rebecca L. Olin,Richard F. Olsson,Richard F. Olsson,Attaphol Pawarode,Edward Peres,Andrew R. Rezvani,David A. Rizzieri,Bipin N. Savani,Harry C. Schouten,Mitchell Sabloff,Matthew D. Seftel,Sachiko Seo,Mohamed L. Sorror,Mohamed L. Sorror,Jeff Szer,Baldeep Wirk,William A. Wood,Andrew S. Artz +52 more
TL;DR: Over the past decade, utilization and survival after allogeneic transplant have increased in patients ≥70 years with hematologic malignancies across the United States.
Journal ArticleDOI
Indications for Hematopoietic Cell Transplantation and Immune Effector Cell Therapy: Guidelines from the American Society for Transplantation and Cellular Therapy.
Abraham S. Kanate,Navneet S. Majhail,Bipin N. Savani,Christopher Bredeson,Richard E. Champlin,Stephen Crawford,Sergio Giralt,Charles F. LeMaistre,David I. Marks,James L. Omel,Paul J. Orchard,Jeanne Palmer,Wael Saber,Wael Saber,Paul Veys,Paul A. Carpenter,Mehdi Hamadani,Mehdi Hamadani +17 more
TL;DR: This manuscript presents the updated recommendations from the ASTCT on indications for HCT and IECT to include new data and to incorporate indications for immune effector cell therapy (IECT) where appropriate.
Journal ArticleDOI
Use of Chimeric Antigen Receptor T Cell Therapy in Clinical Practice for Relapsed/Refractory Aggressive B Cell Non-Hodgkin Lymphoma: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy
Tania Jain,Tania Jain,Merav Bar,Ankit Kansagra,Elise A. Chong,Shahrukh K. Hashmi,Shahrukh K. Hashmi,Sattva S. Neelapu,Michael Byrne,Elad Jacoby,Aleksandr Lazaryan,Caron A. Jacobson,Stephen M. Ansell,Farrukh T. Awan,Linda J. Burns,Veronika Bachanova,Catherine M. Bollard,Paul A. Carpenter,John F. DiPersio,Mehdi Hamadani,Helen E. Heslop,Joshua A. Hill,Joshua A. Hill,Krishna V. Komanduri,Craig Kovitz,Hillard M. Lazarus,Justin M. Serrette,Mohamad Mohty,David B. Miklos,Arnon Nagler,Steven Z. Pavletic,Bipin N. Savani,Stephen J. Schuster,Mohamed A. Kharfan-Dabaja,Miguel-Angel Perales,Miguel-Angel Perales,Yi Lin +36 more
TL;DR: Advice is provided from experts in the fields of hematopoietic cell transplantation, cellular immunotherapy, and lymphoma regarding key clinical questions pertinent to the utilization of CD19 CAR T for the treatment of NHL.
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