CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney
Timothy J. Soos,Tasha N. Sims,Laura Barisoni,K. Lin,Dan R. Littman,Dan R. Littman,Michael L. Dustin,Peter J. Nelson +7 more
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In this paper, the authors utilized CX3CR1GFP+ mice to characterize the anatomy and phenotype of tissue-resident Dendritic cells (DCs) within normal kidney.About:
This article is published in Kidney International.The article was published on 2006-08-01 and is currently open access. It has received 285 citations till now.read more
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Obesity induces a phenotypic switch in adipose tissue macrophage polarization
TL;DR: Diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.
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Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Simon Yona,Ki-Wook Kim,Yochai Wolf,Alexander Mildner,Diana Varol,Michal Breker,Dalit Strauss-Ayali,Sergey Viukov,Martin Guilliams,Alexander V. Misharin,David A. Hume,Harris Perlman,Bernard Malissen,Elazar Zelzer,Steffen Jung +14 more
TL;DR: A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
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Mechanisms of Cisplatin nephrotoxicity.
TL;DR: Recent advances in understanding of cisplatin nephrotoxicity are summarized and it is discussed how these advances might lead to more effective prevention.
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TLR4 activation mediates kidney ischemia/reperfusion injury
Huiling Wu,Gang Chen,Kate Wyburn,Jianlin Yin,Patrick Bertolino,Josette Eris,Stephen I. Alexander,Alexandra F. Sharland,Steven J. Chadban +8 more
TL;DR: Using a mouse model of kidney IRI, a significant increase in TLR4 expression by tubular epithelial cells (TECs) and infiltrating leukocytes within the kidney following ischemia is demonstrated, suggesting thatTLR4 signaling in intrinsic kidney cells plays the dominant role in mediating kidney damage.
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The immune system and kidney disease: basic concepts and clinical implications
TL;DR: The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.
References
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Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
TL;DR: Using in vivo two-photon imaging in neocortex, it is found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions.
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Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.
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ATP mediates rapid microglial response to local brain injury in vivo
Dimitrios Davalos,Jaime Grutzendler,Jaime Grutzendler,Guang Yang,Jiyun Kim,Yi Zuo,Steffen Jung,Dan R. Littman,Michael L. Dustin,Wen-Biao Gan +9 more
TL;DR: Extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglia response towards injury.
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Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria.
Maria Rescigno,Matteo Urbano,Barbara Valzasina,Maura Francolini,Gianluca Rotta,Roberto Bonasio,Francesca Granucci,Jean Pierre Kraehenbuhl,Paola Ricciardi-Castagnoli +8 more
TL;DR: A new mechanism for bacterial uptake in the mucosa tissues that is mediated by dendritic cells (DCs) is reported, which open the tight junctions between epithelial cells, send dendrites outside the epithelium and directly sample bacteria.
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Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.
Steffen Jung,Julio Aliberti,Petra Graemmel,Mary Jean Sunshine,Georg W. Kreutzberg,Alan Sher,Dan R. Littman +6 more
TL;DR: Defying anticipated FKN functions, absence of CX3CR1 interferes neither with monocyte extravasation in a peritonitis model nor with DC migration and differentiation in response to microbial antigens or contact sensitizers.