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Open AccessJournal ArticleDOI

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma

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TLDR
It is demonstrated for the first time that elevated CXCL13 concentration in cerebrospinal fluid (CSF) is prognostic and that CXC chemokine ligand and IL-10 mediate chemotaxis of lymphoma cells isolated from CNS lymphoma lesions.
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This article is published in Blood.The article was published on 2013-06-06 and is currently open access. It has received 178 citations till now. The article focuses on the topics: Lymphoma & CXCL13.

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Journal ArticleDOI

Multi-marker algorithms based on CXCL13, IL-10, sIL-2 receptor, and β2-microglobulin in cerebrospinal fluid to diagnose CNS lymphoma

TL;DR: A diagnostic algorithm that can avoid biopsy by combining these diagnostic biomarkers, which had excellent diagnostic performance and was a prognostic biomarker for CNS lymphoma patients, suggests that multi‐marker algorithms are important diagnostic tools for patients with CNS lymph cancer.
Journal ArticleDOI

Tumor and Cerebrospinal Fluid microRNAs in Primary Central Nervous System Lymphomas

TL;DR: Tissue MiR-155, miR-196b, mi R-9, mi-125b, and mi-R-let-7b expression profiles differentiate PCNSL from n-ML, and none of the examined microRNAs influenced overall survival of PC NSL patients.
Journal ArticleDOI

Endogenous adaptation to low oxygen modulates T-cell regulatory pathways in EAE.

TL;DR: In this paper, the authors define mechanisms by which adaptation to low oxygen functionally ameliorates the signs and symptoms of EAE and for the first time show that tissue hypoxia may fundamentally alter neurodegenerative disease.
Book ChapterDOI

Cerebrospinal fluid biomarkers of malignancies located in the central nervous system.

TL;DR: This chapter provides a summary of the current state of affairs of the field of biomarkers of different types of CNS tumors, where techniques are rapidly progressing to assess these markers with increasing sensitivity and specificity and correlations with clinical parameters are being investigated.
References
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Journal ArticleDOI

Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.

TL;DR: Receiver-operating characteristic (ROC) plots provide a pure index of accuracy by demonstrating the limits of a test's ability to discriminate between alternative states of health over the complete spectrum of operating conditions.
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Basic principles of ROC analysis

TL;DR: ROC analysis is shown to be related in a direct and natural way to cost/benefit analysis of diagnostic decision making and the concepts of "average diagnostic cost" and "average net benefit" are developed and used to identify the optimal compromise among various kinds of diagnostic error.
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Revised response criteria for malignant lymphoma

TL;DR: New guidelines incorporating PET, IHC, and flow cytometry for definitions of response in non-Hodgkin's and Hodgkin's lymphoma are presented and it is hoped that they will be adopted widely by study groups, pharmaceutical and biotechnology companies, and regulatory agencies to facilitate the development of new and more effective therapies to improve the outcome of patients with lymphoma.
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A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

TL;DR: Findings clearly suggest that marked overexpression of the miR-17-92 cluster with occasional gene amplification may play a role in the development of lung cancers, especially in their most aggressive form, small-cell lung cancer, and that the C13orf25 gene may well be serving as a vehicle in this regard.
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Report of an International Workshop to Standardize Baseline Evaluation and Response Criteria for Primary CNS Lymphoma

TL;DR: An international group of experts meeting to review current standards of reporting and to formulate a consensus opinion regarding minimum baseline evaluation and common standards for assessing response to therapy hope that these guidelines will improve communication among investigators and comparability among clinical trials in a way that will allow to develop better therapies for patients.
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