CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma
James L. Rubenstein,Valerie S. Wong,Cigall Kadoch,Hua Xin Gao,Ramon F. Barajas,Lingjing Chen,S. Andrew Josephson,Brian J. Scott,Vanja C. Douglas,Mekhala Maiti,Lawrence D. Kaplan,Patrick A. Treseler,Soonmee Cha,Jimmy Hwang,Paola Cinque,Jason G. Cyster,Clifford A. Lowell +16 more
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TLDR
It is demonstrated for the first time that elevated CXCL13 concentration in cerebrospinal fluid (CSF) is prognostic and that CXC chemokine ligand and IL-10 mediate chemotaxis of lymphoma cells isolated from CNS lymphoma lesions.About:
This article is published in Blood.The article was published on 2013-06-06 and is currently open access. It has received 178 citations till now. The article focuses on the topics: Lymphoma & CXCL13.read more
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Lyme neuroborreliosis—epidemiology, diagnosis and management
TL;DR: There is evidence that patients with post-treatment Lyme disease syndrome do not have ongoing B. burgdorferi infection and, thus, do not benefit from additional antibiotic therapy, and most patients who receive this diagnosis have other illnesses.
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CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond
TL;DR: The complex networks of cellular interactions involving tumoral CXCL13 and CXCR5 integrate to promote cancer cell autonomous and non-autonomous responses, highlighting the relevance of autocrine and paracrine interactions in dictating the cancer phenotype.
Journal ArticleDOI
How I treat CNS lymphomas
TL;DR: The goal is to provide an overview of current knowledge regarding the pathogenesis of CNS lymphomas and to highlight promising strategies that the authors believe to be most effective in establishing diagnosis, staging, and therapeutic management.
Journal ArticleDOI
Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma
James L. Rubenstein,Huimin Geng,Eleanor J. Fraser,Paul Formaker,Lingjing Chen,Jigyasa Sharma,Phoebe Killea,Kaylee Choi,Jenny Ventura,John Kurhanewicz,Clifford A. Lowell,Jimmy Hwang,Patrick A. Treseler,Penny K. Sneed,Jing Li,Xiaomin Wang,Nianhang Chen,Jon A. Gangoiti,Pamela N. Munster,Bertil Damato +19 more
TL;DR: It is concluded that lenalidomide penetrates ventricular CSF and is active as monotherapy in relapsed CNS lymphomas and delays whole brain radiotherapy (WBRT) in patients with inadequate responses to lenalidumide.
References
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Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation.
Mamta Gupta,Jing Jing Han,Mary Stenson,Matthew J. Maurer,Linda Wellik,Guangzhen Hu,Steve Ziesmer,Ahmet Dogan,Thomas E. Witzig +8 more
TL;DR: The results provide the rationale for testing JAK2 inhibitors in DLBCL patients, and indicate that serum IL-10 may be a biomarker to identify patients more likely to respond to Jak2-targeted therapy.
Journal ArticleDOI
Value of combined approach with thallium-201 single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-related primary CNS lymphoma.
Andrea Antinori,G. De Rossi,Adriana Ammassari,Antonella Cingolani,Rita Murri,D. Di Giuda,A. De Luca,Francesco Pierconti,Tommaso Tartaglione,Massimo Scerrati,Luigi Maria Larocca,Luigi Ortona +11 more
TL;DR: Because PCNSL likelihood is extremely high in patients with hyperactive lesions and positive EBV-DNA, brain biopsy could be avoided, and patients could promptly undergo radiotherapy or multimodal therapy.
Value of combined approach with thallium-201 single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-Related primary CNS lymphoma RID G-8810-2011 RID A-1577-2008
A. Antinori,G. De Rossi,Adriana Ammassari,A. Cingolani,R. Murri,D. Di Giuda,Andrea De Luca,Francesco Pierconti,Tommaso Tartaglione,Massimo Scerrati,L. M. Larocca,Luigi Ortona +11 more
TL;DR: In this article, the diagnostic capability of thallium-201 (201Tl) single-photon emission computed tomography (SPECT) combined with Epstein-Barr virus DNA (EBV-DNA) in CSF for the diagnosis of AIDS-related primary CNS lymphoma (PCNSL) was determined.
Journal ArticleDOI
MicroRNA145 Targets BNIP3 and Suppresses Prostate Cancer Progression
Xueqin Chen,Jing Gong,Hao Zeng,Ni Chen,Rui Huang,Ying Huang,Ling Nie,Miao Xu,Juan Xia,Fang Zhao,Wentong Meng,Qiao Zhou +11 more
TL;DR: It is experimentally showed that miR145 negatively regulated BNIP3 by targeting its 3'-untranslated region, which may play a major role in prostate cancer pathogenesis and progression.
Journal ArticleDOI
Protein biomarker identification in the CSF of patients with CNS lymphoma.
Sushmita Roy,S. Andrew Josephson,Jane Fridlyand,Jon Karch,Cigall Kadoch,Juliana Karrim,Lloyd E. Damon,Patrick A. Treseler,Sandeep Kunwar,Marc A. Shuman,Ted Jones,Christopher H. Becker,Howard Schulman,James L. Rubenstein +13 more
TL;DR: It is proposed that the discovery of CSF protein biomarkers will facilitate early and noninvasive diagnosis in patients with lesions not amenable to brain biopsy, as well as provide improved surrogates of prognosis and treatment response in CNS lymphoma and brain metastasis.
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