CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma
James L. Rubenstein,Valerie S. Wong,Cigall Kadoch,Hua Xin Gao,Ramon F. Barajas,Lingjing Chen,S. Andrew Josephson,Brian J. Scott,Vanja C. Douglas,Mekhala Maiti,Lawrence D. Kaplan,Patrick A. Treseler,Soonmee Cha,Jimmy Hwang,Paola Cinque,Jason G. Cyster,Clifford A. Lowell +16 more
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TLDR
It is demonstrated for the first time that elevated CXCL13 concentration in cerebrospinal fluid (CSF) is prognostic and that CXC chemokine ligand and IL-10 mediate chemotaxis of lymphoma cells isolated from CNS lymphoma lesions.About:
This article is published in Blood.The article was published on 2013-06-06 and is currently open access. It has received 178 citations till now. The article focuses on the topics: Lymphoma & CXCL13.read more
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Lyme neuroborreliosis—epidemiology, diagnosis and management
TL;DR: There is evidence that patients with post-treatment Lyme disease syndrome do not have ongoing B. burgdorferi infection and, thus, do not benefit from additional antibiotic therapy, and most patients who receive this diagnosis have other illnesses.
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CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond
TL;DR: The complex networks of cellular interactions involving tumoral CXCL13 and CXCR5 integrate to promote cancer cell autonomous and non-autonomous responses, highlighting the relevance of autocrine and paracrine interactions in dictating the cancer phenotype.
Journal ArticleDOI
How I treat CNS lymphomas
TL;DR: The goal is to provide an overview of current knowledge regarding the pathogenesis of CNS lymphomas and to highlight promising strategies that the authors believe to be most effective in establishing diagnosis, staging, and therapeutic management.
Journal ArticleDOI
Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma
James L. Rubenstein,Huimin Geng,Eleanor J. Fraser,Paul Formaker,Lingjing Chen,Jigyasa Sharma,Phoebe Killea,Kaylee Choi,Jenny Ventura,John Kurhanewicz,Clifford A. Lowell,Jimmy Hwang,Patrick A. Treseler,Penny K. Sneed,Jing Li,Xiaomin Wang,Nianhang Chen,Jon A. Gangoiti,Pamela N. Munster,Bertil Damato +19 more
TL;DR: It is concluded that lenalidomide penetrates ventricular CSF and is active as monotherapy in relapsed CNS lymphomas and delays whole brain radiotherapy (WBRT) in patients with inadequate responses to lenalidumide.
References
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Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system
Alexander Baraniskin,Jan Kuhnhenn,Uwe Schlegel,Andrew T. Chan,Martina Deckert,Ralf Gold,Abdelouahid Maghnouj,Hannah Zöllner,Anke Reinacher-Schick,Wolff Schmiegel,Stephan A. Hahn,Roland Schroers +11 more
TL;DR: CSF miRNAs are potentially useful tools as novel noninvasive biomarker for the diagnosis of PCNSL and combined miRNA analyses resulted in an increased diagnostic accuracy and a remarkable stability of mi RNAs in the CSF.
Journal Article
Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.
Steve Alas,Benjamin Bonavida +1 more
TL;DR: It is demonstrated by phosphoprotein immunoblotting analysis and electrophoretic mobility shift analysis that piceatannol and AG490 inhibit the constitutive activity of STAT3 in 2F7 and U266, respectively, and are a novel class of chemotherapeutic sensitizing agents capable of reversing the drug-resistant phenotype of cytokine-dependent tumor cells.
Journal ArticleDOI
Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS
Finn Sellebjerg,Lars Börnsen,Mohsen Khademi,Martin Krakauer,Tomas Olsson,Jette L. Frederiksen,Per Soelberg Sørensen +6 more
TL;DR: TheChemokine CXCL13 may play a major role in recruitment of B cells and T-cell subsets expressing the chemokine receptor CXCR5 to the CNS in multiple sclerosis (MS), and may be a useful biomarker for treatment effects in MS.
Journal ArticleDOI
Expression of B-cell–attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma
Justine R. Smith,Justine R. Smith,Rita M. Braziel,Samantha Paoletti,Samantha Paoletti,Martin Lipp,Martin Lipp,Mariagrazia Uguccioni,Mariagrazia Uguccioni,James T. Rosenbaum +9 more
TL;DR: Investigation of the expression of B cell-attracting chemokine 1 (BCA-1, CXCL13) in primary central nervous system lymphoma found it to influence tumor development and localization to CNS, suggesting that vascular endothelial BCA-1 expression may be consequent to transcytosis.
Journal ArticleDOI
6q deletions define distinct clinico-pathologic subsets of non-Hodgkin's lymphoma.
Kenneth Offit,Nasser Z. Parsa,Gianluca Gaidano,Daniel A. Filippa,Diane C. Louie,Dorothy Pan,Suresh C. Jhanwar,Riccardo Dalla-Favera,R. S. K. Chaganti +8 more
TL;DR: In this paper, the loss of heterozygosity of 6q loci in non-Hodgkin's lymphoma (NHL) showed two regions of minimal molecular deletion (RMD), an RMD1 encompassing 6q25-27 and an RMMD2 at 6q21-23, and the deletions spanned both RCD1 and RCD3.
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