CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma
James L. Rubenstein,Valerie S. Wong,Cigall Kadoch,Hua Xin Gao,Ramon F. Barajas,Lingjing Chen,S. Andrew Josephson,Brian J. Scott,Vanja C. Douglas,Mekhala Maiti,Lawrence D. Kaplan,Patrick A. Treseler,Soonmee Cha,Jimmy Hwang,Paola Cinque,Jason G. Cyster,Clifford A. Lowell +16 more
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TLDR
It is demonstrated for the first time that elevated CXCL13 concentration in cerebrospinal fluid (CSF) is prognostic and that CXC chemokine ligand and IL-10 mediate chemotaxis of lymphoma cells isolated from CNS lymphoma lesions.About:
This article is published in Blood.The article was published on 2013-06-06 and is currently open access. It has received 178 citations till now. The article focuses on the topics: Lymphoma & CXCL13.read more
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Journal ArticleDOI
Lyme neuroborreliosis—epidemiology, diagnosis and management
TL;DR: There is evidence that patients with post-treatment Lyme disease syndrome do not have ongoing B. burgdorferi infection and, thus, do not benefit from additional antibiotic therapy, and most patients who receive this diagnosis have other illnesses.
Journal ArticleDOI
CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond
TL;DR: The complex networks of cellular interactions involving tumoral CXCL13 and CXCR5 integrate to promote cancer cell autonomous and non-autonomous responses, highlighting the relevance of autocrine and paracrine interactions in dictating the cancer phenotype.
Journal ArticleDOI
How I treat CNS lymphomas
TL;DR: The goal is to provide an overview of current knowledge regarding the pathogenesis of CNS lymphomas and to highlight promising strategies that the authors believe to be most effective in establishing diagnosis, staging, and therapeutic management.
Journal ArticleDOI
Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma
James L. Rubenstein,Huimin Geng,Eleanor J. Fraser,Paul Formaker,Lingjing Chen,Jigyasa Sharma,Phoebe Killea,Kaylee Choi,Jenny Ventura,John Kurhanewicz,Clifford A. Lowell,Jimmy Hwang,Patrick A. Treseler,Penny K. Sneed,Jing Li,Xiaomin Wang,Nianhang Chen,Jon A. Gangoiti,Pamela N. Munster,Bertil Damato +19 more
TL;DR: It is concluded that lenalidomide penetrates ventricular CSF and is active as monotherapy in relapsed CNS lymphomas and delays whole brain radiotherapy (WBRT) in patients with inadequate responses to lenalidumide.
References
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Journal ArticleDOI
CXCL13 and CXCL12 in central nervous system lymphoma patients.
Lars Fischer,Agnieszka Korfel,Sebastian Pfeiffer,Philipp Kiewe,Hans-Dieter Volk,Hüsniye Cakiroglu,Thomas Widmann,Eckhard Thiel +7 more
TL;DR: The results suggest a production of CXCL13 within the CNS of CNS lymphoma patients, which decreases with response to therapy, and may represent a marker for further diagnostic and prognostic studies.
Journal ArticleDOI
Immunochemotherapy with Intensive Consolidation for Primary CNS Lymphoma: A Pilot Study and Prognostic Assessment by Diffusion-Weighted MRI
Matthew J. Wieduwilt,Francisco Valles,Samar Issa,Caroline Behler,Jimmy Hwang,Michael W. McDermott,Patrick A. Treseler,Joan M. O'Brien,Marc A. Shuman,Soonmee Cha,Lloyd E. Damon,James L. Rubenstein +11 more
TL;DR: Tumor ADCmin derived from DW-MRI provided better prognostic information for PCNSL patients treated with the MTR-EA regimen than established clinical risk scores and was significantly associated with shorter progression-free and overall survival.
Journal ArticleDOI
Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma
Chang Ohk Sung,Sang Cheol Kim,Sivasundaram Karnan,Kennosuke Karube,Hyung Jin Shin,Do-Hyun Nam,Yeon-Lim Suh,Seok-Hyung Kim,Ji Yeon Kim,Seok Jin Kim,Won Seog Kim,Masao Seto,Young-Hyeh Ko +12 more
TL;DR: This study identified novel tumor suppressor genes that may serve as therapeutic targets of PCNSL and identified several signal transduction pathways, such as Janus kinase-signal transducers and activators of transcription pathway and adhesion-related pathways, which may be involved in pathogenesis of PC NSL.
Book ChapterDOI
Chemokines and B-cell homing to follicles.
TL;DR: Which chemokine receptors and chemokines might have a role in B cell positioning within lymphoid organs were considered and BLR1 expression became strongly upregulated on immature B cells at about the same time as surface IgD and CD21, suggesting that BLR 1 upregulation may be an important part of the immature to mature B cell transition.
Journal ArticleDOI
The diagnostic utility of brain biopsy procedures in patients with rapidly deteriorating neurological conditions or dementia
S. Andrew Josephson,Alexander M. Papanastassiou,Mitchel S. Berger,Nicholas M. Barbaro,Michael W. McDermott,Joan F. Hilton,Bruce L. Miller,Michael D. Geschwind +7 more
TL;DR: The goals of this analysis were to determine the diagnostic sensitivity of brain biopsy specimens in patients with unexplained neurological conditions and retrospectively identify features of these disorders that may have enabled an earlier diagnosis, which may prevent the need for diagnostic brainBiopsy procedures in the future.
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