CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma
James L. Rubenstein,Valerie S. Wong,Cigall Kadoch,Hua Xin Gao,Ramon F. Barajas,Lingjing Chen,S. Andrew Josephson,Brian J. Scott,Vanja C. Douglas,Mekhala Maiti,Lawrence D. Kaplan,Patrick A. Treseler,Soonmee Cha,Jimmy Hwang,Paola Cinque,Jason G. Cyster,Clifford A. Lowell +16 more
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TLDR
It is demonstrated for the first time that elevated CXCL13 concentration in cerebrospinal fluid (CSF) is prognostic and that CXC chemokine ligand and IL-10 mediate chemotaxis of lymphoma cells isolated from CNS lymphoma lesions.About:
This article is published in Blood.The article was published on 2013-06-06 and is currently open access. It has received 178 citations till now. The article focuses on the topics: Lymphoma & CXCL13.read more
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CXCL13 is androgen-responsive and involved in androgen induced prostate cancer cell migration and invasion
TL;DR: Functional studies demonstrate that reducing endogenous CXCL13 expression in LNCaP cells largely weakens androgen-AR axis induced cell migration and invasion, and implicates for the first time that CxCL13 is an AR target gene and involved in AR-mediated cell Migration and invasion in primary PCa.
Journal ArticleDOI
Biology of CNS lymphoma and the potential of novel agents
TL;DR: The first set of early-phase investigations that target NF-κB in PCNSL have now been completed and support the NF-π hypothesis but at the same time reveal that much work needs to be done to translate these results into meaningful advances in survival for a large fraction of patients.
Journal ArticleDOI
The Combined Performance of ADC, CSF CXC Chemokine Ligand 13, and CSF Interleukin 10 in the Diagnosis of Central Nervous System Lymphoma
Marc C. Mabray,Ramon F. Barajas,Javier Villanueva-Meyer,Chiyuan A. Zhang,Francisco Valles,James L. Rubenstein,Soonmee Cha +6 more
TL;DR: The combined use of ADC, CSF CXC chemokine ligand 13 and interleukin 10 results in increased diagnostic performance for the diagnosis of CNS lymphoma, highlighting the importance of CSF analysis when the diagnosis is considered on the basis of MR imaging.
Journal ArticleDOI
APRIL and BAFF: novel biomarkers for central nervous system lymphoma.
Matthias Mulazzani,Marion Huber,Sabine Borchard,Sigrid Langer,Barbara Angele,Elisabeth Schuh,Edgar Meinl,Martin Dreyling,Tobias Birnbaum,Andreas Straube,Uwe Koedel,Louisa von Baumgarten +11 more
TL;DR: In patients with focal brain lesions, measurement of APRIL in CSF could help accelerating the diagnosis of CNSL, and in vitro, APRIL and BAFF showed anti-apoptotic effects during MTX treatment and mediated chemotaxis of malignant B cells.
Journal ArticleDOI
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention
Tracy O'Connor,Xiaolan Zhou,Xiaolan Zhou,Jan Kosla,Jan Kosla,Arlind Adili,Maria Garcia Beccaria,Elena Kotsiliti,Elena Kotsiliti,Dominik Pfister,Dominik Pfister,Anna Lena Johlke,Ankit Sinha,Roman Sankowski,Markus Schick,Richard Lewis,Nikolaos Dokalis,Bastian Seubert,Bastian Höchst,Donato Inverso,Danijela Heide,Wenlong Zhang,Petra Weihrich,K Manske,Dirk Wohlleber,Martina Anton,Alexander Hoellein,Gitta Maria Seleznik,Juliane Bremer,Sabine Bleul,Hellmut G. Augustin,Hellmut G. Augustin,Florian Scherer,Uwe Koedel,Achim Weber,Ulrike Protzer,Reinhold Förster,Thomas Wirth,Adriano Aguzzi,Felix Meissner,Marco Prinz,Bernd Baumann,Uta E. Höpken,Percy A. Knolle,Louisa von Baumgarten,Ulrich Keller,Ulrich Keller,Mathias Heikenwalder +47 more
TL;DR: Aged, gliotic wild-type mice were more susceptible to forming CNSL than young wild- type mice, and astrocytic CCL19 was observed in both human gliosis and CNSL, suggesting CCL 19-CCR7 interactions may underlie an increased age-related risk for CNSL.
References
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Journal ArticleDOI
Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.
Mark H. Zweig,Gregory Campbell +1 more
TL;DR: Receiver-operating characteristic (ROC) plots provide a pure index of accuracy by demonstrating the limits of a test's ability to discriminate between alternative states of health over the complete spectrum of operating conditions.
Journal ArticleDOI
Basic principles of ROC analysis
TL;DR: ROC analysis is shown to be related in a direct and natural way to cost/benefit analysis of diagnostic decision making and the concepts of "average diagnostic cost" and "average net benefit" are developed and used to identify the optimal compromise among various kinds of diagnostic error.
Journal ArticleDOI
Revised response criteria for malignant lymphoma
Bruce D. Cheson,Beate Pfistner,Malik E. Juweid,Randy D. Gascoyne,Lena Specht,Sandra J. Horning,Bertrand Coiffier,Richard I. Fisher,Anton Hagenbeek,Emanuele Zucca,Steven T. Rosen,Sigrid Stroobants,T. Andrew Lister,Richard T. Hoppe,Martin Dreyling,Kensei Tobinai,Julie M. Vose,Joseph M. Connors,Massimo Federico,Volker Diehl +19 more
TL;DR: New guidelines incorporating PET, IHC, and flow cytometry for definitions of response in non-Hodgkin's and Hodgkin's lymphoma are presented and it is hoped that they will be adopted widely by study groups, pharmaceutical and biotechnology companies, and regulatory agencies to facilitate the development of new and more effective therapies to improve the outcome of patients with lymphoma.
Journal ArticleDOI
A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation
Yoji Hayashita,Hirotaka Osada,Yoshio Tatematsu,Hideki Yamada,Kiyoshi Yanagisawa,Shuta Tomida,Yasushi Yatabe,Katsunobu Kawahara,Yoshitaka Sekido,Takashi Takahashi +9 more
TL;DR: Findings clearly suggest that marked overexpression of the miR-17-92 cluster with occasional gene amplification may play a role in the development of lung cancers, especially in their most aggressive form, small-cell lung cancer, and that the C13orf25 gene may well be serving as a vehicle in this regard.
Journal ArticleDOI
Report of an International Workshop to Standardize Baseline Evaluation and Response Criteria for Primary CNS Lymphoma
Lauren E. Abrey,Tracy T. Batchelor,A. J. M. Ferreri,Mary Gospodarowicz,Elisa Jacobsen Pulczynski,Emanuele Zucca,Justine R. Smith,Agnieszka Korfel,Carole Soussain,Lisa M. DeAngelis,Edward A. Neuwelt,Brian P. O'Neill,Eckhard Thiel,Tamara Shenkier,Fransesc Graus,Martin J. van den Bent,John F. Seymour,Philip Poortmans,James O. Armitage,Franco Cavalli +19 more
TL;DR: An international group of experts meeting to review current standards of reporting and to formulate a consensus opinion regarding minimum baseline evaluation and common standards for assessing response to therapy hope that these guidelines will improve communication among investigators and comparability among clinical trials in a way that will allow to develop better therapies for patients.
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