Journal ArticleDOI
Cyclin-dependent kinase 4/6 inhibitors in breast cancer: palbociclib, ribociclib, and abemaciclib.
TLDR
After having demonstrated impressive activity in ER-positive, HER2-negative metastatic breast cancer, currently CDK4/6 inhibitors are in further development and it is obvious that this class of agents with their efficacy, low and easily manageable toxicity, and oral dosage is a very important treatment option for breast cancer patients.Abstract:
The cyclin D-cyclin dependent kinase (CDK) 4/6-inhibitor of CDK4 (INK4)-retinoblastoma (Rb) pathway plays a crucial role in cell cycle progression and its dysregulation is an important contributor to endocrine therapy resistance. CDK4/6 inhibitors trigger cell cycle arrest in Rb protein (pRb)-competent cells. Recent years have seen the development of selective CDK4/6 inhibitors, which have delivered promising results of efficacy and manageable safety profiles. The main objective of this review is to discuss preclinical and clinical data to date, and ongoing clinical trials with palbociclib, ribociclib, and abemaciclib in breast cancer. A literature search of above topics was carried out using PubMed and data reported at international oncology meetings and clinicaltrials.gov were included. The highly selective oral CDK4/6 inhibitors have been tested in combination with endocrine therapy in Phase III studies in metastatic breast cancer. Results led to the US Food and Drug Administration approval of palbociclib (PD0332991) and ribociclib (LEE011), and abemaciclib (LY2835219) is in development. Studies of these agents, in combination with endocrine therapy, are also underway in ER-positive early breast cancer in the neoadjuvant and adjuvant settings. Moreover, they are also being investigated with other agents in the advanced setting and in triple negative breast cancer. After having demonstrated impressive activity in ER-positive, HER2-negative metastatic breast cancer, currently CDK4/6 inhibitors are in further development. It is obvious that this class of agents with their efficacy, low and easily manageable toxicity, and oral dosage is a very important treatment option for breast cancer patients.read more
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Journal ArticleDOI
The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer
Lei Ding,Jiaqi Cao,Wen Lin,Hongjian Chen,Xianhui Xiong,Hongshun Ao,Min Yu,Jie Lin,Qinghua Cui +8 more
TL;DR: The most relevant CDK inhibitors currently in clinical BC trials are discussed, with special emphasis on CDK4/6 inhibitors used for the treatment of estrogen receptor-positive (ER+)/human epidermal growth factor 2-negative (HER2−) M/ABC patients, as well as more emerging precise therapeutic strategies, such as combination therapies and microRNA (miRNA) therapy.
Journal ArticleDOI
Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies—An Updated Review
Sergiusz Łukasiewicz,Marcin Czeczelewski,Alicja Forma,Jacek Baj,Robert Sitarz,Andrzej Stanisławek +5 more
TL;DR: Based on mRNA gene expression levels, breast cancer can be divided into molecular subtypes (Luminal A, Luminal B, HER2-enriched, and basal-like) as mentioned in this paper.
Journal ArticleDOI
Microbiome-Microbial Metabolome-Cancer Cell Interactions in Breast Cancer-Familiar, but Unexplored.
Edit Mikó,Tünde Kovács,Éva Sebő,Judit Tóth,Tamás Csonka,Gyula Ujlaki,Adrienn Sipos,Judit Szabó,Gábor Méhes,Péter Bai +9 more
TL;DR: The changes to the metabolism of breast cancer cells, as well as the composition of the breast and gut microbiome in breast cancer, and how bacterial dysbiosis interferes with breast cancer treatment through interfering with chemotherapeutic drug metabolism and availability are discussed.
Journal ArticleDOI
HER2-positive breast cancer: Current and new therapeutic strategies.
TL;DR: New strategies in development to treat HER2-positive metastatic breast cancer referring to the mechanisms of action of new drugs and new combinations including results reported so far are examined.
Journal ArticleDOI
Advances in anti-breast cancer drugs and the application of nano-drug delivery systems in breast cancer therapy
TL;DR: The review aims to provide novel concepts for the design of nanocarriers for the delivery of anti-breast cancer drugs and the application of nano-drug delivery systems in breast cancer therapy.
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The retinoblastoma protein and cell cycle control
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Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
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TL;DR: Gen expression profiles from 21 breast cancer data sets and identified 587 TNBC cases may be useful in biomarker selection, drug discovery, and clinical trial design that will enable alignment of TNBC patients to appropriate targeted therapies.
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Palbociclib and Letrozole in Advanced Breast Cancer
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TL;DR: Among patients with previously untreated ER-positive, HER2-negative advanced breast cancer, palbociclib combined with letrozole resulted in significantly longer progression-free survival than that with let rozole alone, although the rates of myelotoxic effects were higher with palbokiclib-letrozoles.
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