Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma.
Thierry Facon,Shaji Kumar,Torben Plesner,Robert Z. Orlowski,Philippe Moreau,Nizar J. Bahlis,Supratik Basu,Hareth Nahi,Cyrille Hulin,Hang Quach,Hartmut Goldschmidt,Michael O'Dwyer,Aurore Perrot,Christopher P. Venner,Katja Weisel,Joseph R. Mace,Noopur Raje,Michel Attal,Mourad Tiab,Margaret Macro,Laurent Frenzel,Xavier Leleu,Tahamtan Ahmadi,Christopher Chiu,Jianping Wang,Rian Van Rampelbergh,Clarissa M. Uhlar,Rachel Kobos,Ming Qi,Saad Z. Usmani,Maia Trial Investigators +30 more
TLDR
Among patients with newly diagnosed multiple myeloma who were ineligible for autologous stem-cell transplantation, the risk of disease progression or death was significantly lower among those who received daratumumab plus lenalidomide and dexamethasone than among thosewho received lenalidmide and Dexameth asone alone.Abstract:
Background Lenalidomide plus dexamethasone is a standard treatment for patients with newly diagnosed multiple myeloma who are ineligible for autologous stem-cell transplantation. We sought...read more
Citations
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Journal ArticleDOI
Multiple myeloma: 2020 update on diagnosis, risk-stratification and management.
TL;DR: Multiple myeloma accounts for approximately 10% of hematologic malignancies in the United States and is the second most common cancer in women.
Journal ArticleDOI
Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial
Peter M. Voorhees,Jonathan L. Kaufman,Jacob P. Laubach,Douglas W. Sborov,Brandi Reeves,Cesar Rodriguez,Ajai Chari,Rebecca Silbermann,Luciano J. Costa,Larry D. Anderson,Nitya Nathwani,Nina Shah,Yvonne A. Efebera,Sarah A. Holstein,Caitlin Costello,Andrzej Jakubowiak,Tanya M. Wildes,Robert Z. Orlowski,Kenneth H. Shain,Andrew J. Cowan,Sean Murphy,Yana Lutska,Huiling Pei,Jon Ukropec,Jessica Vermeulen,Carla de Boer,Daniela Hoehn,Thomas S. Lin,Paul G. Richardson +28 more
TL;DR: Daratumumab with RVd induction and consolidation improved depth of response in patients with transplant-eligible NDMM, with no new safety concerns.
Journal ArticleDOI
Overall survival with daratumumab, bortezomib, melphalan, and prednisone in newly diagnosed multiple myeloma (ALCYONE): a randomised, open-label, phase 3 trial
Maria-Victoria Mateos,Michele Cavo,Joan Bladé,Meletios A. Dimopoulos,Kenshi Suzuki,Andrzej Jakubowiak,Stefan Knop,Chantal Doyen,Paulo Sérgio Lucio,Zsolt Nagy,Ludek Pour,Mark Cook,Sebastian Grosicki,Andre Crepaldi,Anna Marina Liberati,Philip Campbell,Tatiana Shelekhova,Sung-Soo Yoon,Genadi Iosava,Tomoaki Fujisaki,Mamta Garg,Maria Krevvata,Ying Chen,Jianping Wang,Anupa Kudva,Jon Ukropec,Susan Wroblewski,Ming Qi,Rachel Kobos,Jesús F. San-Miguel +29 more
TL;DR: The primary endpoint was progression-free survival, which has been reported previously, and remained significantly improved for the D-VMP group, and results presented are from a prespecified interim analysis for overall survival.
Journal ArticleDOI
Clinical Applications and Future Directions of Minimal Residual Disease Testing in Multiple Myeloma.
TL;DR: This mini-review will focus on currently available techniques and data on MRD testing and their potential future applications.
Journal ArticleDOI
Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
M.A. Dimopoulos,P. Moreau,E. Terpos,M.V. Mateos,Sonja Zweegman,Gordon Cook,Michel Delforge,Roman Hájek,Fredrik Schjesvold,Michele Cavo,H. Goldschmidt,Thierry Facon,H. Einsele,Mario Boccadoro,Jesús F. San-Miguel,Pieter Sonneveld,U. Mey +16 more
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