Journal ArticleDOI
Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology.
TLDR
Existing high-content data derived from clinically and experimentally derived neural tissues point to convergent pathways among these neurodegenerative disorders, which transcend descriptive studies to reach a more integrated understanding of disease pathogenesis and, in some instances, highlighting 'druggable' network nodes.About:
This article is published in Trends in Neurosciences.The article was published on 2009-02-01. It has received 93 citations till now. The article focuses on the topics: Systems biology.read more
Citations
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Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic.
Harald Hampel,Sid E. O'Bryant,José Luis Molinuevo,Henrik Zetterberg,Colin L. Masters,Simone Lista,Steven J. Kiddle,Steven J. Kiddle,Richard Batrla,Kaj Blennow,Kaj Blennow +10 more
TL;DR: This Review summarizes the efforts of an international working group that aimed to survey the current landscape of blood-based AD biomarkers and outlines operational steps for an effective academic–industry co-development pathway from identification and assay development to validation for clinical use.
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The future of Alzheimer's disease: the next 10 years.
Harald Hampel,David Prvulovic,Stefan J. Teipel,Frank Jessen,Christian Luckhaus,Lutz Frölich,Matthias W. Riepe,Richard Dodel,Thomas Leyhe,Lars Bertram,Wolfgang Hoffmann,Frank Faltraco +11 more
TL;DR: An overview on the current state and future developments in epidemiology, pathophysiology, disease conceptualization, diagnostic criteria and their use in research and clinical practice, as well as preventive and symptomatic therapeutic approaches is provided.
Journal ArticleDOI
Impaired neurosteroid synthesis in multiple sclerosis
Farshid Noorbakhsh,Kristofor K. Ellestad,Ferdinand Maingat,Kenneth G. Warren,May H. Han,Lawrence Steinman,Glen B. Baker,Christopher Power +7 more
TL;DR: These multi-platform studies point to impaired neurosteroidogenesis in both multiple sclerosis and experimental autoimmune encephalomyelitis, and indicate that allopregnanolone and perhaps other neurosteroids-like compounds might represent potential biomarkers or therapies for multiple sclerosis.
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Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches
TL;DR: This work investigates the information processing that is performed by the signalling pathways involved in synaptic plasticity in principal neurons of the hippocampus, striatum and cerebellum through quantitative modelling and introduces promising approaches that use advancements in live-cell imaging.
Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders.
TL;DR: This pathway- and network-driven model highlights several potential shared mechanisms in AD and PD that will inform future studies of these and other neurodegenerative disorders and suggests that biomarker and treatment strategies may require simultaneous targeting of multiple components, including some specific to disease stage, in order to assess and modulate neurodegenersation.
References
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Journal ArticleDOI
Systems biology: a brief overview.
TL;DR: To understand biology at the system level, the authors must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism.
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Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
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Towards a proteome-scale map of the human protein–protein interaction network
Jean François Rual,Kavitha Venkatesan,Tong Hao,Tomoko Hirozane-Kishikawa,Amélie Dricot,Ning Li,Gabriel F. Berriz,Francis D. Gibbons,Matija Dreze,Nono Ayivi-Guedehoussou,Niels Klitgord,Christophe Simon,Mike Boxem,Stuart Milstein,Jennifer Rosenberg,Debra S. Goldberg,Lan V. Zhang,Sharyl L. Wong,Giovanni Franklin,Siming Li,Joanna S. Albala,Joanna S. Albala,Janghoo Lim,Carlene Fraughton,Estelle Llamosas,Sebiha Cevik,Camille Bex,Philippe Lamesch,Robert S. Sikorski,Jean Vandenhaute,Huda Y. Zoghbi,Alex Smolyar,Stephanie Bosak,Reynaldo Sequerra,Lynn Doucette-Stamm,Michael E. Cusick,David E. Hill,Frederick P. Roth,Marc Vidal +38 more
TL;DR: An initial version of a proteome-scale map of human binary protein–protein interactions is described, which increases by ∼70% the set of available binary interactions within the tested space and reveals more than 300 new connections to over 100 disease-associated proteins.
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Pathways towards and away from Alzheimer's disease
TL;DR: Rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies in Alzheimer's disease.
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Proteomics to study genes and genomes
TL;DR: Proteomics can be divided into three main areas: protein micro-characterization for large-scale identification of proteins and their post-translational modifications; ‘differential display’ proteomics for comparison of protein levels with potential application in a wide range of diseases; and studies of protein–protein interactions using techniques such as mass spectrometry or the yeast two-hybrid system.