Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.
Gregory P. Strauss,William P. Horan,Brian Kirkpatrick,Bernard A. Fischer,Bernard A. Fischer,William R. Keller,Pinar Miski,Robert W. Buchanan,Robert W. Buchanan,Michael F. Green,William T. Carpenter,William T. Carpenter +11 more
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TLDR
It is suggested that distinct subgroups of patients with elevated AA or DE can be identified within the broader diagnosis of schizophrenia and that these subgroups show clinically meaningful differences in presentation.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-06-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Avolition & Apathy.read more
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Journal ArticleDOI
Updated perspectives on the clinical significance of negative symptoms in patients with schizophrenia
TL;DR: The conceptualization, assessment, and treatment of this complex psychopathological dimension of schizophrenia is provided, and the development of state-of-the-art assessment instruments made in the last decades are provided.
Journal ArticleDOI
The Evolution of Approaches to Schizophrenia Diagnostics: from Kraepelin to ICD-11
TL;DR: The evolution of views on schizophrenia diagnostics over the course of 150 years is presented, beginning from the pre-Kraepelin period and ending with concepts developed in recent decades.
Journal ArticleDOI
Aberrant striatal coupling with default mode and central executive network relates to self-reported avolition and anhedonia in schizophrenia
TL;DR: In this article , the authors investigated the association of large-scale cortico-striatal functional connectivity with self-reported and clinician-rated avolition and anhedonia in subjects with schizophrenia.
Journal ArticleDOI
Brick by Brick: Building a Transdiagnostic Understanding of Inflammation in Psychiatry
TL;DR: In this article , the authors use a Research Domain Criteria framework to discuss proposed mechanisms for inflammation and its effects on the domains of reward processing, psychomotor slowing, and threat reactivity.
Book ChapterDOI
An Affective Neuroscience Model of Impaired Approach Motivation in Schizophrenia
TL;DR: New evidence is presented indicating that schizophrenia patients display deficits in hedonic experience, but that these only emerge at lower levels of motivational significance, and a new theoretical model is proposed that builds upon recent models of negative symptoms and incorporates hedonics abnormalities, reward processing deficits, and dysfunctional cognition-emotion interactions into decision-making processes.
References
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Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Book
Cluster Analysis
TL;DR: This fourth edition of the highly successful Cluster Analysis represents a thorough revision of the third edition and covers new and developing areas such as classification likelihood and neural networks for clustering.
Book
Cluster analysis
TL;DR: Cluster analysis is a multivariate procedure for detecting natural groupings in data that resembles discriminant analysis in one respect—the researcher seeks to classify a set of objects into subgroups although neither the number nor members of the subgroups are known.
Journal ArticleDOI
Negative Symptoms in Schizophrenia: Definition and Reliability
TL;DR: The developed Scale for the Assessment of Negative Symptoms has excellent interrater reliability and the five symptom complexes defined by the scale have good internal consistency, which indicates that the conceptual organization of the scale is also cohesive.
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