Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.
Gregory P. Strauss,William P. Horan,Brian Kirkpatrick,Bernard A. Fischer,Bernard A. Fischer,William R. Keller,Pinar Miski,Robert W. Buchanan,Robert W. Buchanan,Michael F. Green,William T. Carpenter,William T. Carpenter +11 more
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TLDR
It is suggested that distinct subgroups of patients with elevated AA or DE can be identified within the broader diagnosis of schizophrenia and that these subgroups show clinically meaningful differences in presentation.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-06-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Avolition & Apathy.read more
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Journal ArticleDOI
Progress in the Study of Negative Symptoms
TL;DR: Progress is assessed in 3 areas in which William T. Carpenter Jr has been an important investigator: the distinction between primary vs secondary negative symptoms; the appropriate design for treatment trials; and the nosology of negative symptoms.
Journal ArticleDOI
Relationship of amotivation to neurocognition, self-efficacy and functioning in first-episode psychosis: a structural equation modeling approach.
Wing Chung Chang,Vivian Wing Yan Kwong,Clm Hui,Sherry Kit Wa Chan,Edwin Ho Ming Lee,Eric Y.H. Chen +5 more
TL;DR: The results indicate a critical intermediary role of amotivation in linking neurocognitive impairment to functioning in FEP and general self-efficacy may represent a promising treatment target for improvement of motivational deficits and functional outcome in the early illness stage.
Journal ArticleDOI
In and out of schizophrenia: Activation and deactivation of the negative and positive schemas.
TL;DR: It is proposed that the cognitive triad - the negative view of the self, others, and the future - is the source of the content for the negative and positive symptoms of schizophrenia.
Journal ArticleDOI
The relationship between negative symptom subdomains and cognition.
TL;DR: The need to classify DEE and social avolition separately are highlighted as both are necessary in refining the complex relationship between negative symptoms and cognition as well as potentially guiding treatment and management of schizophrenia.
Book ChapterDOI
Schizophrenia: Basic and Clinical.
TL;DR: Pharmacologic challenge studies, postmortem analyses and a recent sufficiently powered genome-wide association study and copy number variant studies provide compelling evidence that NMDA receptor hypofunction is an important pathophsysiologic feature of schizophrenia.
References
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Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Book
Cluster Analysis
TL;DR: This fourth edition of the highly successful Cluster Analysis represents a thorough revision of the third edition and covers new and developing areas such as classification likelihood and neural networks for clustering.
Book
Cluster analysis
TL;DR: Cluster analysis is a multivariate procedure for detecting natural groupings in data that resembles discriminant analysis in one respect—the researcher seeks to classify a set of objects into subgroups although neither the number nor members of the subgroups are known.
Journal ArticleDOI
Negative Symptoms in Schizophrenia: Definition and Reliability
TL;DR: The developed Scale for the Assessment of Negative Symptoms has excellent interrater reliability and the five symptom complexes defined by the scale have good internal consistency, which indicates that the conceptual organization of the scale is also cohesive.
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