Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.
Gregory P. Strauss,William P. Horan,Brian Kirkpatrick,Bernard A. Fischer,Bernard A. Fischer,William R. Keller,Pinar Miski,Robert W. Buchanan,Robert W. Buchanan,Michael F. Green,William T. Carpenter,William T. Carpenter +11 more
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TLDR
It is suggested that distinct subgroups of patients with elevated AA or DE can be identified within the broader diagnosis of schizophrenia and that these subgroups show clinically meaningful differences in presentation.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-06-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Avolition & Apathy.read more
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Emerging 5-HT receptor antagonists for the treatment of Schizophrenia.
TL;DR: These compounds may also have a role in modulating antipsychotic-induced dopamine super-sensitivity and preventing relapse and their utility may also expand outside the spectrum of schizophrenia to encompass Parkinson’s Disease psychosis, major depression, bipolar depression, and dementia-associated apathy.
Journal ArticleDOI
Large-scale evaluation of the Positive and Negative Syndrome Scale (PANSS) symptom architecture in schizophrenia.
Keane Lim,Oon-Him Peh,Zixu Yang,Gurpreet Rekhi,Attilio Rapisarda,Yuen-Mei See,Nur Amirah Abdul Rashid,Mei-San Ang,Sara-Ann Lee,Kang Sim,Hailiang Huang,Todd Lencz,Jimmy Lee,Max Lam +13 more
TL;DR: In this article, a common PANSS factor structure from a large multi-ethnic sample and validate it against a meta-analysis of existing PANSS models was established, and temporal stability of the PANSS model and generalizability to individuals at ultra-high risk (UHR) of psychosis were evaluated.
Journal ArticleDOI
Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study.
Nicolas Hoertel,Nicolas Hoertel,Nicolas Hoertel,Léa Rotenberg,Carlos Blanco,Rachel Pascal de Raykeer,Cécile Hanon,Arthur Kaladjian,Arthur Kaladjian,Frédéric Limosin,Frédéric Limosin,Frédéric Limosin +11 more
TL;DR: In this article, the authors used structural equation modeling to examine the shared and specific effects of psychiatric symptoms on quality of life (QoL) among older adults with schizophrenia spectrum disorder.
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Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation
Jonathan M. Hailwood,Christopher J. Heath,Benjamin U. Phillips,Trevor W. Robbins,Lisa M. Saksida,Timothy J. Bussey,Timothy J. Bussey +6 more
TL;DR: Data suggest that the M1 mAChR may be a novel target for the pharmacological enhancement of effort exertion and consequent rescue of motivational impairments, and that M4 receptors may inadvertently modulate effort exertions through regulation of general locomotor activity levels.
Journal ArticleDOI
Clinical, behavioural and neural validation of the PANSS amotivation factor.
Mariia Kaliuzhna,Matthias Kirschner,Fabien Carruzzo,Matthias N. Hartmann-Riemer,Martin Bischof,Erich Seifritz,Philippe N. Tobler,Stefan Kaiser +7 more
TL;DR: This multi-level validation of the Positive and Negative Symptom Scale (PANSS) confirms that the PANSS clearly allows distinguishing amotivation from diminished expression, as it relates selectively to specific aspects of behaviour and brain function.
References
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The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Book
Cluster Analysis
TL;DR: This fourth edition of the highly successful Cluster Analysis represents a thorough revision of the third edition and covers new and developing areas such as classification likelihood and neural networks for clustering.
Book
Cluster analysis
TL;DR: Cluster analysis is a multivariate procedure for detecting natural groupings in data that resembles discriminant analysis in one respect—the researcher seeks to classify a set of objects into subgroups although neither the number nor members of the subgroups are known.
Journal ArticleDOI
Negative Symptoms in Schizophrenia: Definition and Reliability
TL;DR: The developed Scale for the Assessment of Negative Symptoms has excellent interrater reliability and the five symptom complexes defined by the scale have good internal consistency, which indicates that the conceptual organization of the scale is also cohesive.
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