Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.
Gregory P. Strauss,William P. Horan,Brian Kirkpatrick,Bernard A. Fischer,Bernard A. Fischer,William R. Keller,Pinar Miski,Robert W. Buchanan,Robert W. Buchanan,Michael F. Green,William T. Carpenter,William T. Carpenter +11 more
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TLDR
It is suggested that distinct subgroups of patients with elevated AA or DE can be identified within the broader diagnosis of schizophrenia and that these subgroups show clinically meaningful differences in presentation.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-06-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Avolition & Apathy.read more
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Dissertation
Motivational Deficits in Schizophrenia
TL;DR: The results provide support for the proposal that individuals with schizophrenia have impairments in their ability to compute effort demands, and that these impairments translate into real-world reductions in goal-directed behaviour.
Journal ArticleDOI
The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers
Will Lawn,James Peter Hill,Chandni Hindocha,Chandni Hindocha,J.L.L. Yim,Yumeya Yamamori,Gus Jones,H.R. Walker,Sebastian F. Green,Matthew B. Wall,Matthew B. Wall,Oliver D. Howes,H. Valerie Curran,H. Valerie Curran,Tom P. Freeman,Michael A P Bloomfield +15 more
TL;DR: The monetary incentive delay task elicited expected brain activity during reward anticipation and feedback, including in the insula, caudate, nucleus accumbens, anterior cingulate and orbitofrontal cortex, but across the whole brain, there was no evidence that cannabidiol altered reward-related brain activity.
Journal ArticleDOI
Trait emotional experience in individuals with schizophrenia and youth at clinical high risk for psychosis
Claire I. Yee,Gregory P. Strauss,Daniel N. Allen,Claudia M. Haase,David Kimhy,Vijay A. Mittal +5 more
TL;DR: Both clinical groups showed some evidence of reduced trait positive affect and elevated trait negative affect, suggesting that increasing traitpositive affect and reducing traitnegative affect is an important treatment goal across both populations.
Book ChapterDOI
Measuring Anhedonia in Schizophrenia-Spectrum Disorders: A Selective Update
TL;DR: The main objective of as discussed by the authors was to carry out a selective review of the main measuring instruments used for the assessment of anhedonia and hedonic capacity, including interviews and self-report measures that are either new or of special relevance to research and clinical assessment of schizotypy, schizophrenia, and schizophrenia-spectrum disorders.
Journal ArticleDOI
Alpha7 nicotinic-N-methyl-D-aspartate hypothesis in the treatment of schizophrenia and beyond.
TL;DR: Positive RCTs with novel combination treatments that target the alpha7 nicotinic and NMDA receptors simultaneously may lead to a disease‐modifying therapeutic armamentarium in schizophrenia.
References
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Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Book
Cluster Analysis
TL;DR: This fourth edition of the highly successful Cluster Analysis represents a thorough revision of the third edition and covers new and developing areas such as classification likelihood and neural networks for clustering.
Book
Cluster analysis
TL;DR: Cluster analysis is a multivariate procedure for detecting natural groupings in data that resembles discriminant analysis in one respect—the researcher seeks to classify a set of objects into subgroups although neither the number nor members of the subgroups are known.
Journal ArticleDOI
Negative Symptoms in Schizophrenia: Definition and Reliability
TL;DR: The developed Scale for the Assessment of Negative Symptoms has excellent interrater reliability and the five symptom complexes defined by the scale have good internal consistency, which indicates that the conceptual organization of the scale is also cohesive.
Related Papers (5)
The Structure of Negative Symptoms Within Schizophrenia: Implications for Assessment
Jack J. Blanchard,Alex S. Cohen +1 more