Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.
Gregory P. Strauss,William P. Horan,Brian Kirkpatrick,Bernard A. Fischer,Bernard A. Fischer,William R. Keller,Pinar Miski,Robert W. Buchanan,Robert W. Buchanan,Michael F. Green,William T. Carpenter,William T. Carpenter +11 more
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TLDR
It is suggested that distinct subgroups of patients with elevated AA or DE can be identified within the broader diagnosis of schizophrenia and that these subgroups show clinically meaningful differences in presentation.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-06-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Avolition & Apathy.read more
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Directly and Indirectly Targeting the Glycine Modulatory Site to Modulate NMDA Receptor Function to Address Unmet Medical Needs of Patients With Schizophrenia.
TL;DR: In this article, the authors focus on describing preclinical and clinical studies of direct and indirect GMS modulators in the treatment of schizophrenia, including D-cycloserine, D-serine, glycine transporter 1 (GlyT1) inhibitors, and D-amino acid oxidase (DAO or DAAO) inhibitors.
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OUP accepted manuscript
TL;DR: In this article , the authors examined the role of the MAP on social functioning while accounting for the complex interplay between other psychopathology, and found that the MAP factor/its individual items were closely related to social functioning in patients with schizophrenia.
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Goal-directed planning and action impairments in schizophrenia evaluated in a virtual environment.
Ishraq Siddiqui,Ishraq Siddiqui,Sarah Saperia,Gagan Fervaha,Susana Da Silva,Eliyas Jeffay,Konstantine K. Zakzanis,Ofer Agid,Gary Remington,George Foussias +9 more
TL;DR: Individuals with schizophrenia demonstrated impaired goal-directed planning and action in the context of a simulated everyday errands task, both in terms of reduced capacity to complete errands and reduced efficiency in doing so.
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Motivational and cognitive correlates of community integration in homeless veterans entering a permanent supported housing program.
William P. Horan,Jonathan K. Wynn,Sonya Gabrielian,Shirley M. Glynn,Gerhard Hellemann,Robert S. Kern,Junghee Lee,Stephen R. Marder,Catherine A. Sugar,Michael F. Green +9 more
TL;DR: Interventions that target motivational challenges may have widespread usefulness for enhancing community integration outcomes beyond obtaining housing, and consistent findings across samples point to the importance of motivational factors for understanding the determinants of poor community integration in this complex population.
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Two Factors, Five Factors, or Both? External Validation Studies of Negative Symptom Dimensions in Schizophrenia
TL;DR: In this paper , structural equation modeling (SEM) was used to compare competing dimensional models of negative symptoms to determine the number of latent dimensions that best capture variance in biological, psychological, and clinical variables known to have associations with negative symptoms.
References
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The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Book
Cluster Analysis
TL;DR: This fourth edition of the highly successful Cluster Analysis represents a thorough revision of the third edition and covers new and developing areas such as classification likelihood and neural networks for clustering.
Book
Cluster analysis
TL;DR: Cluster analysis is a multivariate procedure for detecting natural groupings in data that resembles discriminant analysis in one respect—the researcher seeks to classify a set of objects into subgroups although neither the number nor members of the subgroups are known.
Journal ArticleDOI
Negative Symptoms in Schizophrenia: Definition and Reliability
TL;DR: The developed Scale for the Assessment of Negative Symptoms has excellent interrater reliability and the five symptom complexes defined by the scale have good internal consistency, which indicates that the conceptual organization of the scale is also cohesive.
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