Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.
Gregory P. Strauss,William P. Horan,Brian Kirkpatrick,Bernard A. Fischer,Bernard A. Fischer,William R. Keller,Pinar Miski,Robert W. Buchanan,Robert W. Buchanan,Michael F. Green,William T. Carpenter,William T. Carpenter +11 more
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TLDR
It is suggested that distinct subgroups of patients with elevated AA or DE can be identified within the broader diagnosis of schizophrenia and that these subgroups show clinically meaningful differences in presentation.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-06-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Avolition & Apathy.read more
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Negative symptoms in schizophrenia: The prevailing challenges
Nagesh B Pai,Shae-Leigh C Vella +1 more
TL;DR: The results of the qualitative review indicate that the construct ofnegative symptoms requires further delineation and recent work in the area of the assessment of negative symptoms necessitates further development.
Journal ArticleDOI
The effect of deficient muscarinic signaling on commonly reported biochemical effects in schizophrenia and convergence with genetic susceptibility loci in explaining symptom dimensions of psychosis.
TL;DR: The present paradigm predicts the importance of a recent finding of a deletion in a copy number variant of PLCB1 and its potential use if replicated, as one of the first testable biological markers differentiating schizophrenia from bipolar disorder and further subtyping of schizophrenia into deficit and non-deficit.
Journal ArticleDOI
Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
Bénédicte Thonon,Evelyne van Aubel,Ginette Lafit,Clara Della Libera,Frank Larøi,Frank Larøi,Frank Larøi +6 more
TL;DR: The intervention seems to lead to meaningful improvements in motivational negative symptoms and functional outcomes, and the mechanisms of change need to be further investigated.
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Assessment of Lifespan Functioning Attainment (ALFA) scale: A quantitative interview for self-reported current and functional decline in schizophrenia
Jamie W. Joseph,William S. Kremen,William S. Kremen,Stephen J. Glatt,Carol E. Franz,Sharon D. Chandler,Xiaohua Liu,Barbara K. Johnson,Ming T. Tsuang,Ming T. Tsuang,Elizabeth W. Twamley,Elizabeth W. Twamley +11 more
TL;DR: This is the first study to report on a self-reported quantitative assessment of adult lifespan functioning in schizophrenia with a novel and brief scale of adulthood lifespan functioning, the Assessment of Lifespan Functioning Attainment (ALFA).
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Effects of aerobic exercise on cardiorespiratory fitness and social functioning in veterans 40 to 65 years old with schizophrenia
Robert S. Kern,Robert S. Kern,L. Felice Reddy,Amy N. Cohen,Amy N. Cohen,Alexander S. Young,Alexander S. Young,Michael F. Green,Michael F. Green +8 more
TL;DR: The findings indicate it is feasible to improve cardiorespiratory fitness in this clinical population, and there is suggestive evidence that the interventions aimed to do so may also benefit social functioning.
References
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The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Book
Cluster Analysis
TL;DR: This fourth edition of the highly successful Cluster Analysis represents a thorough revision of the third edition and covers new and developing areas such as classification likelihood and neural networks for clustering.
Book
Cluster analysis
TL;DR: Cluster analysis is a multivariate procedure for detecting natural groupings in data that resembles discriminant analysis in one respect—the researcher seeks to classify a set of objects into subgroups although neither the number nor members of the subgroups are known.
Journal ArticleDOI
Negative Symptoms in Schizophrenia: Definition and Reliability
TL;DR: The developed Scale for the Assessment of Negative Symptoms has excellent interrater reliability and the five symptom complexes defined by the scale have good internal consistency, which indicates that the conceptual organization of the scale is also cohesive.
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The Structure of Negative Symptoms Within Schizophrenia: Implications for Assessment
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