Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.
Gregory P. Strauss,William P. Horan,Brian Kirkpatrick,Bernard A. Fischer,Bernard A. Fischer,William R. Keller,Pinar Miski,Robert W. Buchanan,Robert W. Buchanan,Michael F. Green,William T. Carpenter,William T. Carpenter +11 more
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TLDR
It is suggested that distinct subgroups of patients with elevated AA or DE can be identified within the broader diagnosis of schizophrenia and that these subgroups show clinically meaningful differences in presentation.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-06-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Avolition & Apathy.read more
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Journal ArticleDOI
Positive Emotions Program for Schizophrenia (PEPS): a pilot intervention to reduce anhedonia and apathy
Jérôme Favrod,Jérôme Favrod,Alexandra Nguyen,Caroline Fankhauser,Alban Ismailaj,Jean-David Hasler,Abel Ringuet,Shyhrete Rexhaj,Shyhrete Rexhaj,Charles Bonsack +9 more
TL;DR: Findings indicate that PEPS is both a feasible intervention and is associated with an apparently specific reduction of anhedonia and apathy in schizophrenia, which need to be tested further in a controlled study.
Book ChapterDOI
The Behavioral Neuroscience of Motivation: An Overview of Concepts, Measures, and Translational Applications
TL;DR: This chapter provides an overview to the volume "The Behavioural Neuroscience of Motivation", which includes succinct summaries of; The neurobiology of components of healthy motivational drive, neural measures and correlates of motivation in humans and other animals as well as information on disorders in which abnormal motivation plays a major role.
Journal ArticleDOI
Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial
Thomas R. E. Barnes,Verity C. Leeson,Carol Paton,Carol Paton,Céire Costelloe,Judit Simon,Noemi Kiss,David Osborn,David Osborn,Helen Killaspy,Helen Killaspy,Tom K. J. Craig,Shôn Lewis,Patrick Keown,Shajahan Ismail,Mike J. Crawford,David S. Baldwin,Glyn Lewis,Glyn Lewis,John R. Geddes,Manoj Kumar,Rudresh Pathak,Simon Taylor +22 more
TL;DR: Although adjunctive citalopram did not improve negative symptoms overall, there was evidence of some positive effect on avolition/amotivation, recognised as a critical barrier to psychosocial rehabilitation and achieving better social and community functional outcomes.
Journal ArticleDOI
Resting-State Connectivity Biomarkers of Cognitive Performance and Social Function in Individuals With Schizophrenia Spectrum Disorder and Healthy Control Subjects
Joseph D. Viviano,Robert W. Buchanan,Navona Calarco,James M. Gold,George Foussias,Nikhil Bhagwat,Laura Stefanik,Colin Hawco,Pamela DeRosse,Miklos Argyelan,Jessica A. Turner,Sofia Chavez,Peter Kochunov,Peter B. Kingsley,Xiangzhi Zhou,Anil K. Malhotra,Aristotle N. Voineskos +16 more
TL;DR: A brief functional magnetic resonance imaging scan may ultimately be useful in future studies aimed at characterizing long-term illness trajectories and treatments that target specific brain circuitry in those with impaired cognition and function.
Journal ArticleDOI
A Psychometric Comparison of the Clinical Assessment Interview for Negative Symptoms and the Brief Negative Symptom Scale
Gregory P. Strauss,James M. Gold +1 more
TL;DR: Comparisons of the Brief Negative Symptom Scale and Clinical Assessment Interview for Negative Symptoms suggest that both scales have good psychometric properties, but that there are important distinctions among the items related to motivation and pleasure.
References
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Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
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Cluster Analysis
TL;DR: This fourth edition of the highly successful Cluster Analysis represents a thorough revision of the third edition and covers new and developing areas such as classification likelihood and neural networks for clustering.
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Cluster analysis
TL;DR: Cluster analysis is a multivariate procedure for detecting natural groupings in data that resembles discriminant analysis in one respect—the researcher seeks to classify a set of objects into subgroups although neither the number nor members of the subgroups are known.
Journal ArticleDOI
Negative Symptoms in Schizophrenia: Definition and Reliability
TL;DR: The developed Scale for the Assessment of Negative Symptoms has excellent interrater reliability and the five symptom complexes defined by the scale have good internal consistency, which indicates that the conceptual organization of the scale is also cohesive.
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