Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.
Santiago Munné,Joshua Blazek,Michael Large,Pedro A. Martínez-Ortiz,Haley Nisson,Emmeline Liu,Nicoletta Tarozzi,Andrea Borini,Amie Becker,John Z. H. Zhang,S.M. Maxwell,James A. Grifo,D Babariya,Dagan Wells,Elpida Fragouli +14 more
TLDR
The results suggest that embryos with >40% abnormal cells and those with multiple mosaic abnormalities (chaotic mosaics) are likely to have lower OIRs and should be given low transfer priority.About:
This article is published in Fertility and Sterility.The article was published on 2017-07-01 and is currently open access. It has received 205 citations till now.read more
Citations
More filters
Journal ArticleDOI
Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.
Santiago Munné,Brian Kaplan,John L. Frattarelli,Tim Child,Gary S. Nakhuda,F. Nicholas Shamma,Kaylen M. Silverberg,Tasha Kalista,Alan H. Handyside,Mandy G. Katz-Jaffe,Dagan Wells,Tony Gordon,Sharyn Stock-Myer,S.P. Willman,Brian D Acacio,Stuart Lavery,Anna Carby,Robert Boostanfar,Robert Forman,Mark Sedler,Anthea Jackson,Keith Jordan,William B. Schoolcraft,S. McReynolds,Vicki L. Schnell,Randall A. Loy,Samuel J. Chantilis,Lowell Ku,John L. Frattarelli,Arlene J. Morales,H. Randall Craig,Mark Perloe,Craig A. Witz,Wei-Hua Wang,J. Wilcox,J.M. Norian,Stephanie Marshall Thompson,Serena Chen,John Garrisi,Renee Walmsley,Robert J. Mendola,Samuel Pang,Denny Sakkas,Kristin L. Rooney,Rita Sneeringer,M.J. Glassner,Leeanda Wilton,Mirjana Martic,Peter Coleman,Stephanie Shepley,Ginny Mounce,Tracey Griffiths,Ronald F. Feinberg,Keith L. Blauer,Brett Reggio,Rachel Rhinehart,William F. Ziegler,Hina Ahmed,Scott Kratka,Evan M. Rosenbluth,K. Ivani,Angela C. Thyer,T. Minter,Charles M. Miller,Mathias Gysler,Pauline Saunders,Robert F. Casper,Deirdre A. Conway,Mark R. Hughes,Michael Large,Joshua Blazek,Elpida Fragouli,Samer Alfarawati +72 more
TL;DR: There was a significant increase in OPR per embryo transfer with the use of PGT-A in the subgroup of women aged 35-40 years who had two or more embryos that could be biopsied, but this was not significant when analyzed by ITT.
Journal ArticleDOI
Forty years of IVF
Craig Niederberger,Antonio Pellicer,Jacques Cohen,David K. Gardner,Gianpiero D. Palermo,C. O'Neill,S. Chow,Zev Rosenwaks,Ana Cobo,Jason E. Swain,William B. Schoolcraft,René Frydman,L.A. Bishop,Davora Aharon,Catherine M. Gordon,Erika New,Alan H. DeCherney,Seang Lin Tan,Richard J. Paulson,James M. Goldfarb,Mats Brännström,Jacques Donnez,Sherman J. Silber,Marie-Madeleine Dolmans,Marie-Madeleine Dolmans,Joe Leigh Simpson,Alan H. Handyside,Santiago Munné,Cristina Eguizabal,Nuria Montserrat,Juan Carlos Izpisua Belmonte,Alan O Trounson,Carlos Simón,Togas Tulandi,Linda C. Giudice,Robert J. Norman,Aaron J. W. Hsueh,Yingpu Sun,Neri Laufer,Ronit Kochman,Talia Eldar-Geva,Bruno Lunenfeld,Diego Ezcurra,Thomas D'Hooghe,Thomas D'Hooghe,Thomas D'Hooghe,Bart C.J.M. Fauser,Basil C. Tarlatzis,David R. Meldrum,Robert F. Casper,Human M. Fatemi,Paul Devroey,Daniela Galliano,Matts Wikland,Mark Sigman,Richard A. Schoor,Marc Goldstein,Larry I. Lipshultz,Peter N. Schlegel,Alayman Hussein,Robert D. Oates,Robert E. Brannigan,Heather E. Ross,Guido Pennings,Susan C. Klock,Simon Brown,Andre Van Steirteghem,Robert W. Rebar,Robert W. Rebar,Andrew R. LaBarbera,Andrew R. LaBarbera,Andrew R. LaBarbera +71 more
TL;DR: This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field.
Journal ArticleDOI
One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies.
Andrea R. Victor,Jack C. Tyndall,Alan Brake,Laura T. Lepkowsky,Alex E. Murphy,Darren K. Griffin,Rajiv C. McCoy,Frank L. Barnes,Christo Zouves,Manuel Viotti +9 more
TL;DR: After euploid embryos, mosaic embryos can be considered for transfer, prioritizing those of the single segmental mosaic type, and preference should be given to those made at younger ages.
Journal ArticleDOI
Preimplantation genetic testing for aneuploidy by microarray analysis of polar bodies in advanced maternal age: a randomized clinical trial
Willem Verpoest,Catherine Staessen,Patrick M. M. Bossuyt,Veerle Goossens,Gheona Altarescu,Maryse Bonduelle,Martha Devesa,Talia Eldar-Geva,Luca Gianaroli,Georg Griesinger,Georgia Kakourou,Georgia Kokkali,Jana Liebenthron,M.C. Magli,Mònica Parriego,Andreas G. Schmutzler,Monica Tobler,Katrin van der Ven,Joep P.M. Geraedts,Karen Sermon +19 more
TL;DR: The observation that the similarity in birth rates was achieved with fewer transfers, less cryopreservation and fewer miscarriages points to a clinical benefit of PGT-A, and this form of embryo selection may be considered to minimize the number of interventions while producing comparable outcomes.
Journal ArticleDOI
Assessment of aneuploidy concordance between clinical trophectoderm biopsy and blastocyst
Andrea R. Victor,Darren K. Griffin,Alan Brake,Jack C. Tyndall,Alex E. Murphy,Laura T. Lepkowsky,Archana Lal,Christo Zouves,Frank L. Barnes,Rajiv C. McCoy,Manuel Viotti +10 more
TL;DR: The findings of this study refer specifically to a clinical trophectoderm biopsy predicting aneuploidy in the remaining blastocyst, and cannot be extrapolated to deduce the ability of a TE biopsy to predict euploidY in the Blastocyst.
References
More filters
Journal ArticleDOI
Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities*
TL;DR: It is demonstrated that, in morphologically and developmentally normal human embryos, cleavage-stage aneuploidy significantly increases with maternal age, and the results suggest that implantation failure in older women largely could be due to aneuPLoidy.
Journal ArticleDOI
Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities**Presented at the 50th Annual Meeting of The American Fertility Society, San Antonio, Texas, November 4 to 9, 1994, where it was awarded the prize paper of the Society for Assisted Reproductive Technology.
TL;DR: It is demonstrated that, in morphologically and developmentally normal human embryos, cleavage-stage aneuploidy significantly increases with maternal age, and the results suggest that implantation failure in older women largely could be due to aneuPLoidy.
Journal ArticleDOI
Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts
TL;DR: Implantation of 18 mosaic aneuploid blastocysts obtained through in vitro fertilization into 18 women resulted in six pregnancies of normal karyotype, with the birth of six healthy babies.
Journal ArticleDOI
Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage
TL;DR: Even though there is a strong selection against chromosomally abnormal embryos, extended culture to day 5 or 6 cannot be used as a reliable tool to select against clinically relevant chromosome abnormalities such as trisomies.
Journal ArticleDOI
Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
Helen Bolton,Sarah J. L. Graham,Niels Van der Aa,Parveen Kumar,Koen Theunis,Elia Fernandez Gallardo,Thierry Voet,Thierry Voet,Magdalena Zernicka-Goetz +8 more
TL;DR: It is shown that mosaic embryos have full developmental potential, provided they contain sufficient euploid cells, a finding of significance for the assessment of embryo vitality in the clinic.